University of Chester Digital Repository: Recent submissions
Now showing items 21-40 of 8005
-
Growth and micronutrient status parameters of Nigerian preterm infants consuming preterm formula or breastmilkBackground: Moderate-to-late preterm infants (32–34 weeks GA) have increased risk of neonatal morbidities compared to term infants, however dedicated nutritional guidelines are lacking. Methods: Moderate-to-late preterm infants received a preterm formula (n = 17) or breastmilk (n = 24) from age 2–10 weeks in a non-randomized, open-label observational study. Anthropometric measurements were assessed bi-weekly. Blood concentrations of hemoglobin, ferritin, serum retinol, and 25-hydroxy-vitamin D (25OHD) were analyzed at age 2 and 10 weeks. Result: Average growth per day was 14.7 g/kg BW/day in formula-fed and 12.8 g/kg BW/day in breastmilk-fed infants but not different from each other. Length and head circumference in both groups were in line with the median reference values of the Fenton growth chart. At 10 weeks of age, hemoglobin tended to be higher in the formula-fed group (10.2 g/dL vs. 9.6 g/dL, p = 0.053). 25OHD increased in formula- and breastmilk-fed infants from 73.8 to 180.9 nmol/L and from 70.7 to 97.6 nmol/L, respectively. Serum retinol only increased in the formula-fed group (0.63 to 1.02 µmol/L, p < 0.001). Conclusion: Breastfeeding resulted in adequate growth in moderate-late preterm infants but was limiting in some micronutrients. The preterm formula provided adequate micronutrients, but weight gain velocity was higher than the Fenton reference value. Impact statement: Unfortified breastmilk resulted in adequate growth in weight, length and head circumference in Nigerian moderate to late preterm infants during an study period of 8 weeks, but status of vitamin D, vitamin A and iron needs to be monitored. The high-energy formula, developed for very preterm infants, resulted in higher growth in body weight in moderate to late preterm infants than the median of the Fenton preterm growth chart. This study supports the necessity of dedicated nutritional guidelines, and regular monitoring of growth and nutritional status of moderate to late preterm infants.
-
Create a space for belonging for students with parental responsibilityOver the past two decades, students with parental responsibility (“student-parents”) in the UK have been encouraged into university by successive governments’ Widening Participation and Lifelong Learning agendas. However, they have remained largely invisible once they arrive at university (Moreau & Kerner, 2015). Very little attention has been paid to ensuring that student-parents are made to feel that they belong within their institution, or indeed within higher education more generally. This chapter provides a research-informed insight into what we can do to foster a sense of belonging for student-parents. It introduces interventions designed to provide tailored pastoral, academic, and practical support for this committed and motivated group and provides reflections from three student-parents on how a personalised approach supported their sense of belonging during their studies at the University of Chester Law School.
-
How do Ugandan secondary school teachers from diverse Christian traditions and tribes speak about their faith within the Luwero triangle?This thesis contends that there is a gap between the theological priorities of a school's teachers and theologies that inform White mission, postcolonialism, focused on binary distinctions and aspects of Uganda's ecclesial theology. This puzzle emerged from traumatic experiences that confronted my hitherto propositional faith. The research accessed Ugandan storytelling through a co constructed research methodology to address this vacancy. The ultimate objective was to unveil the teacher’s everyday theology through attentive listening. This empirical data modestly continues the postcolonial conversation with Ugandan voices at the fore. The research context is an educational community in rural Uganda, where I have had continual involvement since 2005. The school was resuming normal activities after a two-year hiatus due to the COVID-19 pandemic. My Whiteness and the activities I pursue as an NGO Director create a fluid outsider–insider dynamic. Reflexive attentiveness remained paramount. To inform my self-reflections, I analysed contextually relevant literature and maintained a research journal. This reflexive pursuit was critical because experientially, neither the themes of Whiteness nor colonialism would manifest overtly in the participants' accounts. That did not mean they would not be discovered hidden in their stories if I looked diligently. The teachers’ stories are captured using ten face-to-face interviews and a Talking Circle to cede narrative knowledge. The participants’ selection of ‘Key Informants’ to represent them was crucial in maintaining their voice. Data analysis identified eight interconnecting themes. These unveiled a peaceful and relational local theology. Together, they emphasise the collaborative nature of the “ordinary” miraculous whereby Christian communities participate in the saving actions of God. In addition to their transcribed stories, the teachers wanted a creative ‘takeaway’ from the research, which resulted in an unexpected aesthetic drift. We crafted a short poem to represent each motif using a hybrid Afriku-portraiture methodology. This achieved the aim of developing a theological cycle for ongoing community use. Such poetic knowledge challenged my experience of White missional theology and doctrines, where objectivity readily negates experience. Instead, the poems are a theological source open to creative imaginings. Whilst arguing that this research contributes relatable knowledge, participant numbers, context, and my subjective experience limit this claim. Further studies using a replicable approach would progress this research's findings.
-
Metabolic, androgenic, and physical activity profiles in women aged over 40 years with polycystic ovary syndrome: A comparative analysis using UK Biobank dataBackground: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women, linked to metabolic, hormonal, and psychological issues. Management typically involves lifestyle changes, including increased physical activity and reduced sedentary behaviour. Objectives: To compare the health profiles and behaviours of women with and without PCOS. Design: This study analysed data from the UK Biobank, which is a prospective cohort study. Methods: Women with PCOS in the UK Biobank were identified, while age- and body mass index (BMI)-matched controls were randomly selected. Data on factors associated with PCOS severity and self-reported lifestyle behaviours were analysed. Group differences were tested for significance, and participants were categorised by health behaviours to assess morbidity risk. Results: The study included 319 women with PCOS (mean age: 43.9 years) and 638 in each control group. Significant differences (p < 0.05) were observed in anthropometric (e.g. body weight, BMI, waist and hip circumference, and body fat), cardio-metabolic (e.g. blood pressure, triglycerides, and glycated haemoglobin), and androgenic (e.g. sex hormone-binding globulin) indices. Differences were most pronounced between PCOS and age-matched controls but remained when BMI was also considered. Women with PCOS engaged in less vigorous physical activity and had higher screen time and sedentary behaviours. Those with the lowest physical activity and highest sedentary time had the worst health profiles and highest morbidity risk, regardless of group. Conclusion: Women with PCOS exhibit poorer health despite only slight lifestyle differences. Across all participants, lower physical activity and higher sedentary behaviour were linked to increased health risks. Further research is needed to clarify causal relationships between lifestyle factors and PCOS.
-
Banal deception and human-AI ecosystems: A study of people’s perceptions of LLM-generated deceptive behaviourLarge language models (LLMs) can provide users with false, inaccurate, or misleading information, and we consider the output of this type of information as what Natale calls ‘banal’ deceptive behaviour [53]. Here, we investigate peoples’ perceptions of ChatGPT-generated deceptive behaviour and how this affects people’s behaviour and trust. To do this, we use a mixed-methods approach comprising of (i) an online survey with 220 participants and (ii) semi-structured interviews with 12 participants. Our results show that (i) the most common types of deceptive information encountered were over-simplifications and outdated information; (ii) humans’ perceptions of trust and chat-worthiness of ChatGPT are impacted by ‘banal’ deceptive behaviour; (iii) the perceived responsibility for deception is influenced by education level and the perceived frequency of deceptive information; and (iv) users become more cautious after encountering deceptive information, but they come to trust the technology more when they identify advantages of using it. Our findings contribute to understanding human-AI interaction dynamics in the context of Deceptive AI Ecosystems and highlight the importance of user-centric approaches to mitigating the potential harms of deceptive AI technologies.
-
Misogyny, misogynoir and violent online rhetoric against women and girls in sport: The case of Joey BartonResearch question: This study adopts an intersectional feminist lens to investigate misogynistic and violent online rhetoric directed at women and girls in sport, focusing on the case of former footballer and heavy social media user, Joey Barton. This research aims to fill the gap in understanding how online platforms provide an outlet for, and in many ways amplify, misogyny, creating a hostile environment for female athletes. Research methods: The study employs a thematic analysis of social media data, examining three specific trigger events where Barton targeted women with abusive language: his comments on goalkeeper Mary Earps winning Sports Personality of the Year, his attacks on football pundit Eni Aluko, and his criticism of young goalkeeper Ava Easdon. This qualitative analysis focuses on the nature of the public response and the discursive strategies used. Results and Findings: The findings reveal a pervasive culture of misogyny and online violence directed at women in sport. Barton's behaviour highlights the intersection of gender, race, and online violence, demonstrating how social media platforms can amplify harmful content. Key themes identified include widespread public condemnation, calls for accountability, intersectional violence, and the symbolic use of emojis to convey hostility. Implications: The study highlights the urgent need for effective countermeasures to protect women athletes from abuse and the role of social media platforms in perpetuating harmful content. It also calls for increased accountability and the implementation of robust policies to safeguard female athletes online.
-
Numerical algorithms for nonlinear fractional stochastic Volterra-type equationIn this work, we investigate a class of nonlinear stochastic Volterra-type evolution equations, which can be regarded as an extension of the results reported in Qiao et al. (Fract Calc Appl Anal 27:1136–1161, 2024). For such equations, we propose an Euler scheme and rigorously establish the existence, uniqueness, and regularity of the solution. Moreover, we present the detailed numerical implementation of the scheme and derive the corresponding error estimates.
-
Creative health placements offer student nurses diverse and valuable learning opportunitiesBackground and purpose: This is a perspective on Ridgway et al ‘Creative health a joke or valuable learning experience'. Creative health encompasses creative and arts activities that benefit health and well-being. The article evaluates a creative health placement designed to facilitate students’ learning about creative health and social prescribing, with opportunities to take part in arts activities.
-
Loss of the RNA binding protein HuR in early murine limb mesenchyme does not affect development but leads to impaired bone homeostasis in adulthoodIn this study, we examined how a critical posttranscriptional regulator, the RNA‐binding protein HuR (gene name Elavl1), contributes to the development and maintenance of limb skeletal tissue. Using the Prx1‐Cre knockout model, we examined the effect of germline knockout (Elavl1KO) and limb mesenchyme‐specific knockout (MSC‐Elavl1KO) of HuR on limb development. We found that Elavl1KO disrupted the development of the limb skeleton and was associated with a loss of signaling from the apical ectodermal ridge (AER). In contrast, MSC‐Elavl1KO did not appear to affect skeletal development. Mature MSC‐Elavl1KO mice appeared healthy, but their limb skeleton exhibited abnormal bone structure in both males and females at 2.5 months of age. Osteoblasts isolated from MSC‐Elavl1KO mice exhibited lower expression of osteoblastic marker genes, and their ability to generate a mineralized matrix was markedly impaired. RNA‐Seq analysis of these osteoblasts demonstrated that loss of HuR substantially influenced their transcriptome, affecting genes associated with a wide range of cellular processes. Finally, using siRNA knockdown in the human MG63 cell line, we identified that loss of HuR leads to increased mRNA turnover of the osteoblastic transcription factor Runx2. Overall, the study has demonstrated a critical role for HuR‐mediated posttranscriptional control in skeletal development and homeostasis, but finds that its expression in mesenchyme‐derived cells only becomes critical in mature skeletal tissue.
-
Clinical Spectrum and Prognostic Predictors of Guillain-Barré Syndrome: A Prospective Observational Study From South IndiaIntroduction: Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy and a leading cause of acute flaccid paralysis. Though uncommon, it carries substantial morbidity and mortality. Indian prospective data remain limited, prompting this study to evaluate clinical patterns, complications, and prognostic determinants in a tertiary care cohort. Study: This prospective observational study was conducted at Madras Medical College, Chennai, between May 2024 and May 2025. Ninety consecutive patients aged 12 years and above fulfilling the Asbury and Cornblath criteria for GBS were included. Clinical details, cerebrospinal fluid (CSF) parameters, and electrophysiological subtypes were documented. Patients received intravenous immunoglobulin (IVIG), plasma exchange (PLEX), or supportive care. Outcomes assessed were ventilation requirement, complications, mortality, and functional status at discharge using the modified Rankin Scale (mRS). Results: Ninety patients (mean age 38.5 years) were studied, with a slight male predominance. Antecedent infections were common, mainly respiratory or gastrointestinal. Most patients (over 80%) presented with ascending symmetrical weakness, predominantly of the pure motor type. Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) was the commonest electrophysiological subtype, followed by axonal variants. About one-fourth required intensive care unit (ICU) admission, and one-fifth needed mechanical ventilation. At discharge, one-third regained independent ambulation, while 9% died. Poor outcomes were associated with older age, cranial nerve and autonomic involvement, and axonal forms. Conclusion: GBS in this cohort predominantly affected young to middle-aged adults, with classical ascending weakness and AIDP as the commonest pattern, though axonal forms were frequent. One-third recovered well, but nearly half remained disabled and 9% died. Early recognition of predictors such as older age, cranial nerve palsy, autonomic dysfunction, and axonal subtypes is crucial for risk stratification and intensive management.
-
Carbon fiber-reinforced piezoelectric nanocomposites: Design, fabrication and evaluation for damage detection and energy harvestingCarbon fiber-reinforced polymers (CFRPs) can be used in aging infrastructures as a reinforcement because of their excellent mechanical properties, and they can also be used in the support maintenance and repair work of these structures. However, the development of CFRPs as reinforcement while achieving self-powered damage detection is still challenging. Herein, a sodium potassium niobate (KNN) nanoparticle-filled epoxy (KNN–EP) plate was fabricated and combined with advanced CFRP electrodes. The obtained composites exhibited dramatically enhanced mechanical properties. In addition, CFRP contributed to the energy harvesting output (peak-to-peak output voltage V p p = 7.25 mV), which was over 600 % higher than that of the KNN–EP plate. Thus, this composite could work as a force sensor for damage detection. In the end-notch bending test, the voltage signals generated by CFRP/KNN–EP composite accurately corresponded to the crack growth, which could provide the real-time crack state and prediction of fracture occurrence. Therefore, this work provided a new strategy for structural enhancement and kinetic energy harvesting, which can be used to detect damage behavior in infrastructures.
-
Positive psychology and positive education: a strengths-based approach to SENThis paper, originating from the ‘Power of Us!’ conference held in June 2025, reflects on the session titled: Positive psychology and positive education: a strengths-based approach to SEN, which looked at how positive psychology and positive education can be applied to better support students, and with a particular focus on those with SENs.The paper offers an insight into the session, sharing reflections from the discussions and research findings, and calls for action to create a truly inclusive educational system.
-
An elite perspective on interviewing entrepreneurs – methodological considerations for the entrepreneurship fieldPurpose: Elite interviewing is a well-established area of interview research methods. Nevertheless, the actual casting of an “elite” has been generally conducted in a prima facie or broad manner. A consideration of entrepreneurs and owner-managers as “elites” has been less profiled and received less attention, therefore the paper views the entrepreneurs and owner-managers as constituting a form of “local elite” within given and varying sectorial, regional and community boundaries. The authors argue that a consideration of entrepreneurs as “local elites” and transferring knowledge from an elite interviewing perspective may strongly support scholarly research in the entrepreneurship field. Design/methodology/approach: The study conducts a comprehensive narrative literature review of elite interviewing literature and transfers key methodological insights to the entrepreneurship field. The methodological contribution based on literature is complemented by experiences and observations from an extensive inductive interview study with over 30 entrepreneurs of German manufacturing Small and Medium-sized Entities (SMEs) and are used to reflect on, and refine, interview research approaches with entrepreneurs. Findings: The reflections and discussions in this paper provide valuable insights for other researchers conducting research in entrepreneurship domains regarding the power dynamics of negotiating access, procedural issues of interviews and thereby enhancing the quality of data. Originality/value: The contribution to knowledge is mainly of a methodological nature. While the paper takes a novel act of recasting elite interviewing in the SME and entrepreneurship context, the paper methodologically contributes to the entrepreneurship and elite interview literature thereby facilitating higher quality interviews.
-
Numerical approximation for a stochastic time-fractional cable equationAn efficient numerical method is proposed to address a stochastic time-fractional cable equation driven by fractionally integrated additive noise. Under the reasonable assumptions, we rigorously establish for the first time, the existence, uniqueness, and regularity of the mild solution for this equation. For spatial discretization, a semi-discrete scheme is constructed employing the Galerkin FEM, and the optimal spatial error estimate is derived based on the semigroup approach. In temporal discretization, a piecewise constant function is introduced to approximate the noise, leading to the formulation of a regularized stochastic time-fractional cable equation. A detailed proof of the temporal error estimates is provided via the semigroup approach. Numerical experiments demonstrate that the temporal convergence order attains O ( τ 1 / 2 ) for initial data of either smooth or non-smooth type. The order is independent of the parameters α 1 ∈ ( 0 , 1 ) , α 2 ∈ ( 0 , 1 ) , and β ∈ ( 0 , 1 ) in the equation. These results perfectly align with the theoretical predictions.
-
Erratum to: An interpretative phenomenological analysis (IPA) of coercion towards community dwelling older adults with dementia: findings from Mysore studies of natal effects on ageing and health (MYNAH)A co-author’s name was published incorrectly in the original publication of the article. The author name “Muffadal Bharmal” should be “Mufaddal Bharmal”. The original article has been updated accordingly.
-
The role of social capital in SMEs for polycrisis managementSince 2020 several crises have brought unexpected and complex economic, political and social challenges to small and medium-sized enterprises (SMEs). SMEs have had to innovate to survive but urgent responses often preclude strategic consideration for long-term repercussions. This paper explores the role of social capital in organisations and considers how it can assist in navigating external crises and buffering against future change. Using a hybrid social capital perspective we examine the prospects for SMEs to survive crises using two rounds of purposive and convenience sampling driven semi-structured interviews undertaken twelve months apart with the same respondents drawn from a diverse range of industries such as catering, digital agencies, education, and sport organisations. The interviews explored social capital through the attributes of stakeholder trust, reciprocity and shared values also discerning how integration with, and provocation from, wider networks impacts SMEs. The paper critically evaluates the role of social capital in SMEs during current times of seemingly ever-present crisis. Having clear awareness of the influence and role of social capital, its attributes and its role in shaping the continuity of an organisation through crises is a key application of this work that can be directly used within other organisations of this type.
-
Mapping the age of autistic spectrum condition diagnosis, affected by sex and Intellectual disabilityIntroduction/purpose: Autism is a complex neurodevelopmental condition thought to affect 1 in 100 children globally. More commonly diagnosed in males, and during childhood, diagnoses are increasingly being made throughout adulthood. Purpose: To establish what age autistic people receive their diagnosis, and whether the age of diagnosis was influenced by their sex and by the presence of intellectual disability. Design: A quantitative, cross-sectional, retrospective study. Data was collected from the Primary Care records of 6 GP Practices covering Ellesmere Port, a large town in Northwest England with 71,210 people registered. Mean age of diagnosis was calculated for the group then for each subgroup, to allow comparison between males and females, and those with and without a documented intellectual disability. Findings: Data from 1130 autistic participants were analysed. Age of participants was between 3 - 81 years with an age of autism diagnosis of 1 - 72 years. 85.6% of participants were diagnosed with autism by the age of 25 years, most commonly at 3 years of age (11.9%). The average age of diagnosis was 2.48 years later for females diagnosed across the lifespan. Average age of diagnosis was 5.05 years later for those with a learning disability. Practical implications: This study highlights the importance of healthcare professionals, educators and care givers recognising autistic traits in people across the lifespan, including the potential for diagnostic overshadowing. There are implications for commissioning autistic services, to ensure adequate assessment pathway capacity for adolescents and adults as well as children.
-
Quantifying the optimal factor VIII levels to achieve patient-centric and clinician-relevant outcomes among people with hemophilia A: a SHELF elicitation studyBackground: Hemophilia A is an inherited bleeding disorder caused by a deficiency of clotting factor VIII (FVIII), leading to joint bleeding and arthropathy. While prophylactic FVIII therapy reduces bleeding, evidence suggests maintaining higher FVIII levels (FL) may better protect joint health, particularly in physically active individuals and those with joint damage. However, data on optimal FLs required to prevent joint deterioration and complications remains limited. Research design and methods: This study utilized the Sheffield Elicitation Framework (SHELF) methodology to elicit expert opinions on optimal FLs for patient-centric and clinical outcomes. Five European hemophilia experts participated in virtual workshops, providing probability-based estimates of FLs required to prevent bleed-related hospitalizations, orthopedic procedures, target joint incidence, and support physical activity without additional infusions or joint damage. Results: Experts consistently recommended higher FLs for individuals with joint damage than for those without. Optimal average FLs ranged from 24% to 51%, exceeding traditionally recommended prophylactic trough levels (3–5%). Considerable uncertainty was noted around FLs for physical activity, reflecting the complexity of individualized care. Conclusions: Standard prophylaxis regimens may not provide sufficient protection for all patients, particularly those with joint damage. A personalized treatment approach, targeting higher FLs when necessary, may be critical for optimizing outcomes.
-
Educational strategies for managing moral distress in student nurses: A scoping reviewAims: To explore what content, teaching and learning activities are advocated by nurse educators to mitigate moral distress and related concepts in student nurses. Review Methods: The review was conducted according to Joanna Briggs Institute guidelines. The search strategy adopted their three-step method for systematic reviews. The eligibility criteria reflected the Population, Concept, Context format. Results: Following searches, 3809 records were screened against eligibility criteria, resulting in 42 eligible papers being included; 29 research studies and 13 non-empirical papers. We identified 236 content suggestions, mapped to 70 subject codes. Also, 217 teaching and learning activities are suggested and mapped to 41 coded activities. Data is charted in tables and figures and results are discussed per related concept of moral distress. Conclusions: Educational content, and teaching and learning activities are heterogenous across the concepts influencing moral distress. There is overlap of content across different concepts. Moral sensitivity received the most publications. Development of research and educational strategies addressing other interrelated concepts would be advantageous for evidence-based curriculum development. Recommendations are made to develop evidence-based content and teaching and learning activities.
-
Correction to: Visualization for epidemiological modelling: challenges, solutions, reflections and recommendations (2022) by Dykes et al.In the original version of this article, references 113–120, 123–140 and 143 were incorrectly numbered. This has been corrected on the publisher’s website.










