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Links of adversity in childhood with mental and physical health outcomes: A systematic review of longitudinal mediating and moderating mechanisms
Hales, George K. Saribaz, Zeliha E. Debowska, Agata Rowe, Richard
Hales, George K.
Saribaz, Zeliha E.
Debowska, Agata
Rowe, Richard
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2022-02-28
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Abstract
Adverse childhood experiences (ACEs) have been associated with causes of early death, addiction, mental illness, and poor
health. However, studies investigating underlying mechanisms often rely on cross-sectional data or inappropriate study designs.
To prevent the negative sequelae associated with ACEs, it is imperative to understand the mechanisms underlying the
prospective relationship. The aim of this present review was to provide a synthesis and critical evaluation of the literature
regarding the mechanisms underlying this relationship. A search in SCOPUS, MedLine via Ovid, PsycINFO via Ovid, and Web of
Science was performed. Studies that utilised a prospective design assessing ACEs in childhood or adolescence, outcomes in
adulthood, and analysed either a mediating or moderating relationship were included, unless the study relied on informant
report or official records to assess childhood maltreatment types of ACEs. Twenty-two studies examining a longitudinal
mediation or moderation were included in a systematic review. A review of the studies found links to psychopathology,
delinquent and problem behaviours, poor physical health, and poor socioeconomic outcomes. A clear image of underlying
mechanisms is not forthcoming due to (a) poor study design in relation to assessing longitudinal mechanisms, and (b) heterogeneity in the adversities, mechanisms, and outcomes assessed. Based on the review, several gaps and limitations are
highlighted and discussed.
Citation
Hales, G. K., Saribaz, Z. E., Debowska, A., & Rowe, R. (2023). Links of adversity in childhood with mental and physical health outcomes: A systematic review of longitudinal mediating and moderating mechanisms. Trauma, Violence, & Abuse, 24(3), 1465–1482. https://doi.org/10.1177/15248380221075087
Publisher
SAGE Publications
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Trauma, Violence, & Abuse
Research Unit
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Article
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Description
This document is the Accepted Manuscript version of a published work that appeared in final form in [Trauma, Violence, & Abuse]. To access the final edited and published work see http://dx.doi.org/10.1177/15248380221075087].
Series/Report no.
ISSN
1524-8380
EISSN
1552-8324