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Modelling the molecular mechanisms of ageing
Mc Auley, Mark T. Martinez Guimera, Alvaro Hodgson, David McDonald, Neil Mooney, Kathleen M. Morgan, Amy Proctor, Carole
Mc Auley, Mark T.
Martinez Guimera, Alvaro
Hodgson, David
McDonald, Neil
Mooney, Kathleen M.
Morgan, Amy
Proctor, Carole
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Publication Date
2017-02-23
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Abstract
The ageing process is driven at the cellular level by random molecular damage which slowly accumulates with age. Although cells possess mechanisms to repair or remove damage, they are not 100% efficient and their efficiency declines with age. There are many molecular mechanisms involved and exogenous factors such as stress also contribute to the ageing process. The complexity of the ageing process has stimulated the use of computational modelling in order to increase our understanding of the system, test hypotheses and make testable predictions. As many different mechanisms are involved, a wide range of models have been developed. This paper gives an overview of the types of models that have been developed, the range of tools used, modelling standards, and discusses many specific examples of models which have been grouped according to the main mechanisms that they address. We conclude by discussing the opportunities and challenges for future modelling in this field.
Citation
Mc Auley, M. T., Martinez Guimera, A., Hodgson, D.,
McDonald, N., Mooney, K. M., Morgan, A., & Proctor, C. (2017). Modelling the molecular mechanisms of ageing. Bioscience Reports, 37(1). https://doi.org/10.1042/BSR20160177
Publisher
Portland Press
Journal
Bioscience Reports
Research Unit
DOI
10.1042/BSR20160177
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PubMed Central ID
Type
Article
Language
en
Description
This document is the Accepted Manuscript version of a published work that appeared in final form in Bioscience Reports. To access the final edited and published work see http://www.bioscirep.org/content/37/1/BSR20160177.
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ISSN
EISSN
1573-4935