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Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population
Isgin-Atici, Kubra Alathari, Buthaina E. Turan-Demirci, Busra Sendur, Suleyman Nahit Incilay, Lay Ellahi, Basma Alikasifoglu, Mehmet Erbas, Tomris Buyuktuncer, Zehra Santhanakrishnan, Vimaleswaran Karani
Isgin-Atici, Kubra
Alathari, Buthaina E.
Turan-Demirci, Busra
Sendur, Suleyman Nahit
Incilay, Lay
Ellahi, Basma
Alikasifoglu, Mehmet
Erbas, Tomris
Buyuktuncer, Zehra
Santhanakrishnan, Vimaleswaran Karani
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2022-01-17
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Abstract
Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24-50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status.
Citation
Isgin-Atici, K., Alathari, B. E., Turan-Demirci, B., Sendur, S. N., Incilay, L., Ellahi, B., Alikasifoglu, M., Erbas, T., Buyuktuncer, Z., & Vimaleswaran, K. S. (2022). Interaction between dietary fat Intake and metabolic genetic risk score on 25-Hydroxyvitamin D Concentrations in a Turkish adult population. Nutrients, 14(2), 382. https://doi.org/10.3390/nu14020382
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MDPI
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Nutrients
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DOI
10.3390/nu14020382
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Article
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2072-6643