Increased circulating Dickkopf-1 in Paget's disease of bone
Marshall, Michael J. Evans, Sally F. Sharp, Christopher A. Powell, Diane E. McCarthy, Helen S. Davie, Michael W. J.
Marshall, Michael J.
Evans, Sally F.
Sharp, Christopher A.
Powell, Diane E.
McCarthy, Helen S.
Davie, Michael W. J.
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2009-07
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Abstract
This article discusses Dickkopf-1 (Dkk-1), which is a secreted inhibitor of Wnt signaling which in adults regulates bone turnover. Dkk-1 over-production is implicated in osteolytic disease where it inhibits bone formation and stimulates bone breakdown. Recently it was reported that osteoblastic cells from Paget's disease of bone (PDB) over-expressed Dkk-1. This study aimed yo see if increased Dkk-1 was detected in serum from patients with PDB. The results showed that Dkk-1 and total serum alkaline phosphatase activity (tsAP) were significantly elevated in sera from PDB patients. Patients with polyostotic PDB had significantly higher levels of tsAP but not Dkk-1, than monostotic patients. TsAP but not Dkk-1, was significantly lower in sera from bisphosphonate treated versus untreated PDB patients. Dkk-1 and tsAP were not significantly correlated. Dkk-1 may be a useful biomarker of PDB and the authors speculate that Dkk-1 may play a central role in the etiology of PDB.
Citation
Clinical Biochemistry, 42(10-11), 2009, pp. 965-969
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Elsevier
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Clinical Biochemistry
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Article
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en
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0009-9120