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    Recombination: Multiply infected spleen cells in HIV patients

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    Authors
    Jung, Andreas
    Maier, Reinhard
    Vartanian, Jean-Pierre
    Bocharov, Gennady
    Jung, Volker
    Fischer, Ulrike
    Meese, Eckart
    Wain-Hobson, Simon
    Meyerhans, Andreas
    Publication Date
    2002-07-11
    
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    Abstract
    The genome of the human immunodeficiency virus is highly prone to recombination, although it is not obvious whether recombinants arise infrequently or whether they are constantly being spawned but escape identification because of the massive and rapid turnover of virus particles. Here we use fluorescence in situ hybridization to estimate the number of proviruses harboured by individual splenocytes from two HIV patients, and determine the extent of recombination by sequencing amplified DNA from these cells. We find an average of three or four proviruses per cell and evidence for huge numbers of recombinants and extensive genetic variation. Although this creates problems for phylogenetic analyses, which ignore recombination effects, the intracellular variation may help to broaden immune recognition.
    Citation
    Nature, 2002, 418, p. 144
    Publisher
    Nature Publishing Group
    Journal
    Nature
    URI
    http://hdl.handle.net/10034/97006
    DOI
    10.1038/418144a
    Additional Links
    http://www.nature.com/nature/index.html
    Type
    Article
    Language
    en
    Description
    This article is not available through ChesterRep.
    ISSN
    00280836
    Sponsors
    This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
    ae974a485f413a2113503eed53cd6c53
    10.1038/418144a
    Scopus Count
    Collections
    Mathematics

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