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    Heat shock proteins form part of a danger signal cascade in response to lipopolysaccharide and GroEL

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    Authors
    Davies, Emma L.
    Bacelar, Maria M. F. V. G.
    Marshall, Michael J.
    Johnson, Emileigh
    Wardle, Terrence D.
    Andrew, Sarah M.
    Williams, John H. H.
    Affiliation
    University of Chester; The Robert Jones and Agnes Hunt Orthopaedic Hospital; Countess of Chester Hospital
    Publication Date
    2006-05-26
    
    Metadata
    Show full item record
    Abstract
    An increasing number of cell types, including peripheral blood mononuclear cells (PBMCs), have been demonstrated to release heat shock proteins (Hsps). This paper investigates further the hypothesis that Hsps are danger signals. PBMCs and Jurkat cells released Hsp70 (0·22 and 0·7 ng/106 cells, respectively) into medium over 24 h at 37°C. Release of Hsp70 was stimulated 10-fold by GroEL (P < 0·001) and more than threefold by lipopolysaccharide (LPS) (P < 0·001). Although Hsp60 could be detected in the medium of cells cultured at 37°C for 24 h, the low rates of release were due probably to cell damage. Significant release of Hsp60 was observed when Jurkat cells were exposed to GroEL (2·88 ng/106 cells) or LPS (1·40 ng/106 cells). The data are consistent with the hypothesis that Hsp70 and Hsp60 are part of a danger signalling cascade in response to bacterial infection.
    Citation
    Davies, E L., Bacelar, M. M. F. V. G., Marshall, M. J., Johnson, E., Wardle, T. D., Andrew, S. M., & Williams, J. H. H. (2006). Heat shock proteins form part of a danger signal cascade in response to lipopolysaccharide and GroEL. Clinical & Experimental Immunology, 451(1), 183-189. https://doi.org/10.1111/j.1365-2249.2006.03109.x
    Publisher
    Wiley
    Journal
    Clinical and Experimental Immunology
    URI
    http://hdl.handle.net/10034/95141
    DOI
    10.1111/j.1365-2249.2006.03109.x
    Additional Links
    http://www3.interscience.wiley.com/journal/117996139
    Type
    Article
    Language
    en
    Description
    This article is not available through ChesterRep.
    ISSN
    0009-9104
    EISSN
    1365-2249
    Sponsors
    This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
    ae974a485f413a2113503eed53cd6c53
    10.1111/j.1365-2249.2006.03109.x
    Scopus Count
    Collections
    Biological Sciences

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