Show simple item record

dc.contributor.authorMcCaddon, Andrew*
dc.contributor.authorBleenow, Kaj*
dc.contributor.authorHudson, Peter R.*
dc.contributor.authorHughes, Alan*
dc.contributor.authorBarber, Joan*
dc.contributor.authorGray, Rob*
dc.contributor.authorDavies, Gareth K.*
dc.contributor.authorWilliams, John H. H.*
dc.contributor.authorDuguid, Jennifer*
dc.contributor.authorLloyd, Alwyn*
dc.contributor.authorTandy, Steve*
dc.contributor.authorEverall, Marge*
dc.contributor.authorCattell, Howard*
dc.contributor.authorMcCaddon, Anne*
dc.contributor.authorEllis, Dick*
dc.contributor.authorPalmer, Mona*
dc.contributor.authorBogdanovic, Nenad*
dc.contributor.authorGottfires, Carl-Gerhard*
dc.contributor.authorZetterberg, Henrik*
dc.contributor.authorRymo, Lars*
dc.contributor.authorRegland, Bjorn*
dc.date.accessioned2009-06-15T11:29:28Z
dc.date.available2009-06-15T11:29:28Z
dc.date.issued2004
dc.identifier.citationDementia and Geriatric Cognitive Disorders, 2004, 17(3), pp. 215-221.
dc.identifier.issn1420-8008en
dc.identifier.issn1421-9824en
dc.identifier.doi10.1159/000076359
dc.identifier.urihttp://hdl.handle.net/10034/70457
dc.descriptionThis article is not available through ChesterRep.
dc.description.abstractIsoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.
dc.description.sponsorshipThis article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
dc.language.isoenen
dc.publisherS. Karger AG
dc.relation.urlhttp://www.karger.comen
dc.subjectvitamin B12en
dc.subjectAlzheimer's diseaseen
dc.subjectholo-transcobaliaminen
dc.titleTranscobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's diseaseen
dc.typeArticleen
dc.contributor.departmentUniversity of Wales College of Medicine ; University of Goteborg ; Wrexham Maelor Hospital ; Royal Alexandra Hospital, Paisley ; Garnock Day Hospital/Ayrshire Central Hospital, Irvine ; Royal Alexandra Hospital, Paisley ; Wrexham Maelor Hospital ; University College Chester ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; University of Wales College of Medicine ; University Hospital of Wales, Cardiff ; University of Goteborg ; Huddinge University Hospital, Stockholm ; University of Goteborg ; University of Goteborg ; University of Goteborg ; University of Goteborg
dc.identifier.journalDementia and Geriatric Cognitive Disordersen
html.description.abstractIsoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.


This item appears in the following Collection(s)

Show simple item record