Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease
Hudson, Peter R.
Davies, Gareth K.
Williams, John H. H.
AffiliationUniversity of Wales College of Medicine ; University of Goteborg ; Wrexham Maelor Hospital ; Royal Alexandra Hospital, Paisley ; Garnock Day Hospital/Ayrshire Central Hospital, Irvine ; Royal Alexandra Hospital, Paisley ; Wrexham Maelor Hospital ; University College Chester ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; University of Wales College of Medicine ; University Hospital of Wales, Cardiff ; University of Goteborg ; Huddinge University Hospital, Stockholm ; University of Goteborg ; University of Goteborg ; University of Goteborg ; University of Goteborg
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AbstractIsoforms of the vitamin B<12< carrier protein transcobalamin (TC) might influence its cellular availability and contribute to the association between disrupted single-carbon metabolism and Alzheimer's disease (AD). We therefore investigated the relationships between the TC 776C>G (Pro259Arg) genetic polymorphism, total serum cobalamin and holo-TC levels, and disease onset in 70 patients with clinically diagnosed AD and 74 healthy elderly controls. TC 776C>G polymorphism was also determined for 94 histopathologically confirmed AD patients and 107 controls. Serum holo-TC levels were significantly higher in TC 776C homozygotes (p = 0.04). Kaplan-Meier survival functions differed between homozygous genotypes (Cox's F-Test F(42, 46) = 2.1; p = 0.008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study.
CitationDementia and Geriatric Cognitive Disorders, 2004, 17(3), pp. 215-221.
PublisherS. Karger AG
DescriptionThis article is not available through ChesterRep.
SponsorsThis article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.