• A Novel Averaging Principle Provides Insights in the Impact of Intratumoral Heterogeneity on Tumor Progression

      Hatzikirou, Haralampos; orcid: 0000-0002-1270-7885; email: haralampos.hatzikirou@ku.ac.ae; Kavallaris, Nikos I.; Leocata, Marta; orcid: 0000-0002-5261-3699; email: mleocata@luiss.it (MDPI, 2021-10-09)
      Typically stochastic differential equations (SDEs) involve an additive or multiplicative noise term. Here, we are interested in stochastic differential equations for which the white noise is nonlinearly integrated into the corresponding evolution term, typically termed as random ordinary differential equations (RODEs). The classical averaging methods fail to treat such RODEs. Therefore, we introduce a novel averaging method appropriate to be applied to a specific class of RODEs. To exemplify the importance of our method, we apply it to an important biomedical problem, in particular, we implement the method to the assessment of intratumoral heterogeneity impact on tumor dynamics. Precisely, we model gliomas according to a well-known Go or Grow (GoG) model, and tumor heterogeneity is modeled as a stochastic process. It has been shown that the corresponding deterministic GoG model exhibits an emerging Allee effect (bistability). In contrast, we analytically and computationally show that the introduction of white noise, as a model of intratumoral heterogeneity, leads to monostable tumor growth. This monostability behavior is also derived even when spatial cell diffusion is taken into account.
    • A Comprehensive Review of the Composition, Nutritional Value, and Functional Properties of Camel Milk Fat

      Bakry, Ibrahim A; Yang, Lan; Farag, Mohamed A.; orcid: 0000-0001-5139-1863; email: mohamed.alifarag@aucegypt.edu; Korma, Sameh A; Khalifa, Ibrahim; orcid: 0000-0002-7648-2961; email: Ibrahiem.khalifa@fagr.bu.edu.eg; Cacciotti, Ilaria; orcid: 0000-0002-3478-6510; Ziedan, Noha I.; Jin, Jun; Jin, Qingzhe; Wei, Wei; et al. (MDPI, 2021-09-13)
      Recently, camel milk (CM) has been considered as a health-promoting icon due to its medicinal and nutritional benefits. CM fat globule membrane has numerous health-promoting properties, such as anti-adhesion and anti-bacterial properties, which are suitable for people who are allergic to cow’s milk. CM contains milk fat globules with a small size, which accounts for their rapid digestion. Moreover, it also comprises lower amounts of cholesterol and saturated fatty acids concurrent with higher levels of essential fatty acids than cow milk, with an improved lipid profile manifested by reducing cholesterol levels in the blood. In addition, it is rich in phospholipids, especially plasmalogens and sphingomyelin, suggesting that CM fat may meet the daily nutritional requirements of adults and infants. Thus, CM and its dairy products have become more attractive for consumers. In view of this, we performed a comprehensive review of CM fat’s composition and nutritional properties. The overall goal is to increase knowledge related to CM fat characteristics and modify its unfavorable perception. Future studies are expected to be directed toward a better understanding of CM fat, which appears to be promising in the design and formulation of new products with significant health-promoting benefits.
    • New Self-dual Codes from 2 x 2 block circulant matrices, Group Rings and Neighbours of Neighbours

      Gildea, Joe; Kaya, Abidin; Roberts, Adam; Taylor, Rhian; Tylyshchak, Alexander; University of Chester; Harmony Public Schools; Uzhgorod National University (American Institute of Mathematical Sciences, 2021-09-01)
      In this paper, we construct new self-dual codes from a construction that involves a unique combination; $2 \times 2$ block circulant matrices, group rings and a reverse circulant matrix. There are certain conditions, specified in this paper, where this new construction yields self-dual codes. The theory is supported by the construction of self-dual codes over the rings $\FF_2$, $\FF_2+u\FF_2$ and $\FF_4+u\FF_4$. Using extensions and neighbours of codes, we construct $32$ new self-dual codes of length $68$. We construct 48 new best known singly-even self-dual codes of length 96.
    • Layer Dynamics for the one dimensional $\eps$-dependent Cahn-Hilliard / Allen-Cahn Equation

      Antonopoulou, Dimitra; Karali, Georgia; Tzirakis, Konstantinos; University of Chester; University of Crete; IACM/FORTH (Springer, 2021-08-27)
      We study the dynamics of the one-dimensional ε-dependent Cahn-Hilliard / Allen-Cahn equation within a neighborhood of an equilibrium of N transition layers, that in general does not conserve mass. Two different settings are considered which differ in that, for the second, we impose a mass-conservation constraint in place of one of the zero-mass flux boundary conditions at x = 1. Motivated by the study of Carr and Pego on the layered metastable patterns of Allen-Cahn in [10], and by this of Bates and Xun in [5] for the Cahn-Hilliard equation, we implement an N-dimensional, and a mass-conservative N−1-dimensional manifold respectively; therein, a metastable state with N transition layers is approximated. We then determine, for both cases, the essential dynamics of the layers (ode systems with the equations of motion), expressed in terms of local coordinates relative to the manifold used. In particular, we estimate the spectrum of the linearized Cahn-Hilliard / Allen-Cahn operator, and specify wide families of ε-dependent weights δ(ε), µ(ε), acting at each part of the operator, for which the dynamics are stable and rest exponentially small in ε. Our analysis enlightens the role of mass conservation in the classification of the general mixed problem into two main categories where the solution has a profile close to Allen-Cahn, or, when the mass is conserved, close to the Cahn-Hilliard solution.
    • New Extremal Binary Self-dual Codes from block circulant matrices and block quadratic residue circulant matrices

      Gildea, Joe; Kaya, Abidin; Taylor, Rhian; Tylyshchak, Alexander; Yildiz, Bahattin; University of Chester; Sampoerna University; Uzhgorod National University; Northern Arizona University (Elsevier, 2021-08-20)
      In this paper, we construct self-dual codes from a construction that involves both block circulant matrices and block quadratic residue circulant matrices. We provide conditions when this construction can yield self-dual codes. We construct self-dual codes of various lengths over F2 and F2 + uF2. Using extensions, neighbours and sequences of neighbours, we construct many new self-dual codes. In particular, we construct one new self-dual code of length 66 and 51 new self-dual codes of length 68.
    • Oscillatory and stability of a mixed type difference equation with variable coefficients

      Yan, Yubin; Pinelas, Sandra; Ramdani, Nedjem; Yenicerioglu, Ali Fuat; RUDN University; University of Saad Dahleb Blida; Kocaeli University; University of Chester (Inderscience, 2021-08-12)
      The goal of this paper is to study the oscillatory and stability of the mixed type difference equation with variable coefficients \[ \Delta x(n)=\sum_{i=1}^{\ell}p_{i}(n)x(\tau_{i}(n))+\sum_{j=1}^{m}q_{j}(n)x(\sigma_{i}(n)),\quad n\ge n_{0}, \] where $\tau_{i}(n)$ is the delay term and $\sigma_{j}(n)$ is the advance term and they are positive real sequences for $i=1,\cdots,l$ and $j=1,\cdots,m$, respectively, and $p_{i}(n)$ and $q_{j}(n)$ are real functions. This paper generalise some known results and the examples illustrate the results.
    • Spatial Discretization for Stochastic Semi-Linear Subdiffusion Equations Driven by Fractionally Integrated Multiplicative Space-Time White Noise

      Yan, Yubin; Hoult, James; Wang, Junmei; University of Chester; LuLiang University (MDPI, 2021-08-12)
      Spatial discretization of the stochastic semilinear subdiffusion driven by integrated multiplicative space-time white noise is considered. The spatial discretization scheme discussed in Gy\"ongy \cite{gyo_space} and Anton et al. \cite{antcohque} for stochastic quasi-linear parabolic partial differential equations driven by multiplicative space-time noise is extended to the stochastic subdiffusion. The nonlinear terms $f$ and $\sigma$ satisfy the global Lipschitz conditions and the linear growth conditions. The space derivative and the integrated multiplicative space-time white noise are discretized by using finite difference methods. Based on the approximations of the Green functions which are expressed with the Mittag-Leffler functions, the optimal spatial convergence rates of the proposed numerical method are proved uniformly in space under the suitable smoothness assumptions of the initial values.
    • Error estimates of a continuous Galerkin time stepping method for subdiffusion problem

      Yan, Yubin; Yan, Yuyuan; Liang, Zongqi; Egwu, Bernard; Jimei University; University of Chester (Springer, 2021-07-29)
      A continuous Galerkin time stepping method is introduced and analyzed for subdiffusion problem in an abstract setting. The approximate solution will be sought as a continuous piecewise linear function in time $t$ and the test space is based on the discontinuous piecewise constant functions. We prove that the proposed time stepping method has the convergence order $O(\tau^{1+ \alpha}), \, \alpha \in (0, 1)$ for general sectorial elliptic operators for nonsmooth data by using the Laplace transform method, where $\tau$ is the time step size. This convergence order is higher than the convergence orders of the popular convolution quadrature methods (e.g., Lubich's convolution methods) and L-type methods (e.g., L1 method), which have only $O(\tau)$ convergence for the nonsmooth data. Numerical examples are given to verify the robustness of the time discretization schemes with respect to data regularity.
    • New binary self-dual codes of lengths 56, 58, 64, 80 and 92 from a modification of the four circulant construction.

      Gildea, Joe; Korban, Adrian; Roberts, Adam; University of Chester (Elsevier, 2021-05-31)
      In this work, we give a new technique for constructing self-dual codes over commutative Frobenius rings using $\lambda$-circulant matrices. The new construction was derived as a modification of the well-known four circulant construction of self-dual codes. Applying this technique together with the building-up construction, we construct singly-even binary self-dual codes of lengths 56, 58, 64, 80 and 92 that were not known in the literature before. Singly-even self-dual codes of length 80 with $\beta \in \{2,4,5,6,8\}$ in their weight enumerators are constructed for the first time in the literature.
    • Composite Matrices from Group Rings, Composite G-Codes and Constructions of Self-Dual Codes

      Dougherty, Steven; Gildea, Joe; Korban, Adrian; Kaya, Abidin; University of Scranton; University of Chester; Harmony School of Technology (Springer, 2021-05-19)
      In this work, we define composite matrices which are derived from group rings. We extend the idea of G-codes to composite G-codes. We show that these codes are ideals in a group ring, where the ring is a finite commutative Frobenius ring and G is an arbitrary finite group. We prove that the dual of a composite G-code is also a composite G-code. We also define quasi-composite G-codes. Additionally, we study generator matrices, which consist of the identity matrices and the composite matrices. Together with the generator matrices, the well known extension method, the neighbour method and its generalization, we find extremal binary self-dual codes of length 68 with new weight enumerators for the rare parameters $\gamma$ = 7; 8 and 9: In particular, we find 49 new such codes. Moreover, we show that the codes we find are inaccessible from other constructions.
    • G-Codes, self-dual G-Codes and reversible G-Codes over the Ring Bj,k

      Dougherty, Steven; Gildea, Joe; Korban, Adrian; Sahinkaya, Serap; Tarsus University; University of Chester (Springer, 2021-05-03)
      In this work, we study a new family of rings, Bj,k, whose base field is the finite field Fpr . We study the structure of this family of rings and show that each member of the family is a commutative Frobenius ring. We define a Gray map for the new family of rings, study G-codes, self-dual G-codes, and reversible G-codes over this family. In particular, we show that the projection of a G-code over Bj,k to a code over Bl,m is also a G-code and the image under the Gray map of a self-dual G-code is also a self-dual G-code when the characteristic of the base field is 2. Moreover, we show that the image of a reversible G-code under the Gray map is also a reversible G2j+k-code. The Gray images of these codes are shown to have a rich automorphism group which arises from the algebraic structure of the rings and the groups. Finally, we show that quasi-G codes, which are the images of G-codes under the Gray map, are also Gs-codes for some s.
    • The multi-dimensional Stochastic Stefan Financial Model for a portfolio of assets

      Antonopoulou, Dimitra; Bitsaki, Marina; Karali, Georgia; University of Chester; University of Crete (American Institute of Mathematical Sciences (AIMS), 2021-04-01)
      The financial model proposed in this work involves the liquidation process of a portfolio of n assets through sell or (and) buy orders placed, in a logarithmic scale, at a (vectorial) price with volatility. We present the rigorous mathematical formulation of this model in a financial setting resulting to an n-dimensional outer parabolic Stefan problem with noise. The moving boundary encloses the areas of zero trading, the so-called solid phase. We will focus on a case of financial interest when one or more markets are considered. In particular, our aim is to estimate for a short time period the areas of zero trading, and their diameter which approximates the minimum of the n spreads of the portfolio assets for orders from the n limit order books of each asset respectively. In dimensions n = 3, and for zero volatility, this problem stands as a mean field model for Ostwald ripening, and has been proposed and analyzed by Niethammer in [25], and in [7] in a more general setting. There in, when the initial moving boundary consists of well separated spheres, a first order approximation system of odes had been rigorously derived for the dynamics of the interfaces and the asymptotic pro le of the solution. In our financial case, we propose a spherical moving boundaries approach where the zero trading area consists of a union of spherical domains centered at portfolios various prices, while each sphere may correspond to a different market; the relevant radii represent the half of the minimum spread. We apply It^o calculus and provide second order formal asymptotics for the stochastic version dynamics, written as a system of stochastic differential equations for the radii evolution in time. A second order approximation seems to disconnect the financial model from the large diffusion assumption for the trading density. Moreover, we solve the approximating systems numerically.
    • Entropy-driven cell decision-making predicts "fluid-to-solid" transition in multicellular systems

      Kavallaris, Nikos; Barua, Arnab; Syga, Simon; Mascheroni, Pietro; Meyer-Hermann, Michael; Deutsch, Andreas; Hatzikirou, Haralampos; University of Chester; Helmholtz Centre for Infection Research; Technische Univesität Dresden; Technische Universität Braunschweig; Khalifa University (IOP Publishing, 2020-12-22)
      Cellular decision making allows cells to assume functionally different phenotypes in response to microenvironmental cues, with or without genetic change. It is an open question, how individual cell decisions influence the dynamics at the tissue level. Here, we study spatio-temporal pattern formation in a population of cells exhibiting phenotypic plasticity, which is a paradigm of cell decision making. We focus on the migration/resting and the migration/proliferation plasticity which underly the epithelial-mesenchymal transition (EMT) and the go or grow dichotomy. We assume that cells change their phenotype in order to minimize their microenvironmental entropy following the LEUP (Least microEnvironmental Uncertainty Principle) hypothesis. In turn, we study the impact of the LEUP-driven migration/resting and migration/proliferation plasticity on the corresponding multicellular spatiotemporal dynamics with a stochastic cell-based mathematical model for the spatio-temporal dynamics of the cell phenotypes. In the case of the go or rest plasticity, a corresponding mean-field approximation allows to identify a bistable switching mechanism between a diffusive (fluid) and an epithelial (solid) tissue phase which depends on the sensitivity of the phenotypes to the environment. For the go or grow plasticity, we show the possibility of Turing pattern formation for the "solid" tissue phase and its relation with the parameters of the LEUP-driven cell decisions.
    • Self-Dual Codes using Bisymmetric Matrices and Group Rings

      Gildea, Joe; Kaya, Abidin; Korban, Adrian; Tylyshchak, Alexander; University of Chester ; Sampoerna University ; University of Chester: Uzhgorod National University (Elsevier, 2020-08-14)
      In this work, we describe a construction in which we combine together the idea of a bisymmetric matrix and group rings. Applying this construction over the ring F4 + uF4 together with the well known extension and neighbour methods, we construct new self-dual codes of length 68: In particular, we find 41 new codes of length 68 that were not known in the literature before.
    • 2^n Bordered Constructions of Self-Dual codes from Group Rings

      Dougherty, Steven; Gildea, Joe; Kaya, Abidin; University of Scranton; University of Chester; Sampoerna Academy (Elsevier, 2020-08-04)
      Self-dual codes, which are codes that are equal to their orthogonal, are a widely studied family of codes. Various techniques involving circulant matrices and matrices from group rings have been used to construct such codes. Moreover, families of rings have been used, together with a Gray map, to construct binary self-dual codes. In this paper, we introduce a new bordered construction over group rings for self-dual codes by combining many of the previously used techniques. The purpose of this is to construct self-dual codes that were missed using classical construction techniques by constructing self-dual codes with different automorphism groups. We apply the technique to codes over finite commutative Frobenius rings of characteristic 2 and several group rings and use these to construct interesting binary self-dual codes. In particular, we construct some extremal self-dual codes length 64 and 68, constructing 30 new extremal self-dual codes of length 68.
    • An analysis of the L1 scheme for stochastic subdiffusion problem driven by integrated space-time white noise

      Yan, Yubin; Yan, Yuyuan; Wu, Xiaolei; University of Chester, Lvliang University, Jimei University (Elsevier, 2020-06-02)
      We consider the strong convergence of the numerical methods for solving stochastic subdiffusion problem driven by an integrated space-time white noise. The time fractional derivative is approximated by using the L1 scheme and the time fractional integral is approximated with the Lubich's first order convolution quadrature formula. We use the Euler method to approximate the noise in time and use the truncated series to approximate the noise in space. The spatial variable is discretized by using the linear finite element method. Applying the idea in Gunzburger \et (Math. Comp. 88(2019), pp. 1715-1741), we express the approximate solutions of the fully discrete scheme by the convolution of the piecewise constant function and the inverse Laplace transform of the resolvent related function. Based on such convolution expressions of the approximate solutions, we obtain the optimal convergence orders of the fully discrete scheme in spatial multi-dimensional cases by using the Laplace transform method and the corresponding resolvent estimates.
    • New binary self-dual codes via a generalization of the four circulant construction

      Gildea, Joe; Kaya, Abidin; Yildiz, Bahattin; University of Chester ; Sampoerna University ; Northern Arizona University (Croatian Mathematical Society, 2020-05-31)
      In this work, we generalize the four circulant construction for self-dual codes. By applying the constructions over the alphabets $\mathbb{F}_2$, $\mathbb{F}_2+u\mathbb{F}_2$, $\mathbb{F}_4+u\mathbb{F}_4$, we were able to obtain extremal binary self-dual codes of lengths 40, 64 including new extremal binary self-dual codes of length 68. More precisely, 43 new extremal binary self-dual codes of length 68, with rare new parameters have been constructed.
    • Higher Order Time Stepping Methods for Subdiffusion Problems Based on Weighted and Shifted Grünwald–Letnikov Formulae with Nonsmooth Data

      Yan, yubin; Wang, Yanyong; Yan, Yuyuan; Pani, Amiya K.; University of Chester, Lvliang University, Jimei University, Indian Institute of Technology Bombay (Springer Link, 2020-05-19)
      Two higher order time stepping methods for solving subdiffusion problems are studied in this paper. The Caputo time fractional derivatives are approximated by using the weighted and shifted Gr\"unwald-Letnikov formulae introduced in Tian et al. [Math. Comp. 84 (2015), pp. 2703-2727]. After correcting a few starting steps, the proposed time stepping methods have the optimal convergence orders $O(k^2)$ and $ O(k^3)$, respectively for any fixed time $t$ for both smooth and nonsmooth data. The error estimates are proved by directly bounding the approximation errors of the kernel functions. Moreover, we also present briefly the applicabilities of our time stepping schemes to various other fractional evolution equations. Finally, some numerical examples are given to show that the numerical results are consistent with the proven theoretical results.
    • A Modified Bordered Construction for Self-Dual Codes from Group Rings

      Kaya, Abidin; Tylyshchak, Alexander; Yildiz, Bahattin; Gildea, Joe; University of Chester; Sampoerna University; Uzhgorod State University; Northern Arizona University (Jacodesmath Institute, 2020-05-07)
      We describe a bordered construction for self-dual codes coming from group rings. We apply the constructions coming from the cyclic and dihedral groups over several alphabets to obtain extremal binary self-dual codes of various lengths. In particular we find a new extremal binary self-dual code of length 78.
    • Finite-time blow-up of a non-local stochastic parabolic problem

      Kavallaris, Nikos I.; Yan, Yubin; University of Chester (Elsevier, 2020-04-13)
      The main aim of the current work is the study of the conditions under which (finite-time) blow-up of a non-local stochastic parabolic problem occurs. We first establish the existence and uniqueness of the local-in-time weak solution for such problem. The first part of the manuscript deals with the investigation of the conditions which guarantee the occurrence of noise-induced blow-up. In the second part we first prove the $C^{1}$-spatial regularity of the solution. Then, based on this regularity result, and using a strong positivity result we derive, for first in the literature of SPDEs, a Hopf's type boundary value point lemma. The preceding results together with Kaplan's eigenfunction method are then employed to provide a (non-local) drift term induced blow-up result. In the last part of the paper, we present a method which provides an upper bound of the probability of (non-local) drift term induced blow-up.