• Homocysteine and cognitive decline in healthy elderly

      McCaddon, Andrew; Hudson, Peter R.; Davies, Gareth K.; Hughes, Alan; Williams, John H. H.; Wilkinson, Clare; University of Wales College of Medicine ; Wrexham Maelor Hospital ; Wrexham Maelor Hospital ; Royal Alexandra Hospital, Paisley ; Chester College ; University of Wales College of Medicine (Karger, 2001-09)
      Serum homocysteine is increased, and correlates inversely with cognitive scores, in Alzheimer's disease (AD), vascular dementia and "age-associated memory impairment". Elevated levels might signal accelerated cognitive decline, although this remains to be established. We therefore repeated Mini-Mental State Examinations, together with additional ADAS-Cog assessments, in 32 healthy elderly individuals to determine whether prior homocysteine levels predicted cognitive changes over a 5-year period.