Structural characterisation of two pharmaceutically important steroids by solid-state NMR
Authors
Othman, AbdullahHarris, Robin K.
Hodgkinson, Paul
Christopher, Elizabeth A.
Lancaster, Robert W.
Affiliation
University of Durham ; University of Durham ; University of Durham ; University of Chester/University of Durham ; University of DurhamPublication Date
2008
Metadata
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Several crystal modifications of two steroids (androsterone and beclomethasone dipropionate) have been characterised by solid-state NMR methods, and the chemical shifts between the different forms compared. The gradual loss of water from androsterone hemihydrate has been monitored by XRPD. The crystal structures are discussed in relation to the NMR data. That of the beclomethasone dipropionate ethyl acetate solvate has been determined for the first time. It is found that there are clear channels containing the ethyl acetate molecules, which are apparently not incorporated by hydrogen bonding. Carbon-13 CPMAS spectra with long contact times and MAS proton spectra are used to show the mobility of ethyl acetate molecules in the BDP solvate. The second-order effect of chlorine on the 13C spectrum of beclomethasone dipropionate monohydrate has been explored by varying the applied magnetic field.Citation
New Journal of Chemistry, 32, (2008), pp. 1796-1806Journal
New Journal of ChemistryDOI
10.1039/b803586eAdditional Links
http://www.rsc.org/njcType
ArticleLanguage
enDescription
This article is not available through ChesterRep.ISSN
1144054613699261
ae974a485f413a2113503eed53cd6c53
10.1039/b803586e