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    A bio-assay for effectors of osteoclast differentiation in serum from patients with bone disease

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    Authors
    Dugard, Marit-Naomi
    Sharp, Christopher A.
    Evans, Sally F.
    Williams, John H. H.
    Davie, Michael W. J.
    Marshall, Michael J.
    Affiliation
    Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; University of Chester ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry ; Charles Salt Centre, Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Trust in Oswestry
    Publication Date
    2005-06
    
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    Abstract
    Osteoclast differentiation and activity, and hence bone loss, depend on two opposing cytokines. Receptor activator of NF-κB ligand (RANKL) produced by osteoblasts and T-cells stimulates, while osteoprotegerin inhibits. Both of these cytokines are found in serum. Our aim was to develop a functional assay for any factors present in human serum that can affect osteoclast differentiation and to assess whether any such factors vary in diseases in which bone loss occurs.
    Citation
    Clinica Chimica Acta, 356(1-2), (2005), pp. 154-163.
    Publisher
    Elsevier
    Journal
    Clinica Chimica Acta
    URI
    http://hdl.handle.net/10034/67764
    DOI
    10.1016/j.cccn.2005.01.020
    Additional Links
    http://www.elsevier.com/wps/find/journaldescription.cws_home/506018/description#description
    Type
    Article
    Language
    en
    Description
    This article is not available through ChesterRep.
    ISSN
    0009-8981
    ae974a485f413a2113503eed53cd6c53
    10.1016/j.cccn.2005.01.020
    Scopus Count
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    Biological Sciences

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