• Login / Register
    View Item 
    •   Home
    • Faculty of Science and Engineering
    • Mathematics
    • Mathematics
    • View Item
    •   Home
    • Faculty of Science and Engineering
    • Mathematics
    • Mathematics
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChesterRepCommunitiesTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalProfilesView

    My Account

    LoginRegister

    About

    AboutUniversity of Chester

    Statistics

    Display statistics

    A genetic-algorithm approach to simulating human immunodeficiency virus evolution reveals the strong impact of multiply infected cells and recombination

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Authors
    Bocharov, Gennady
    Ford, Neville J.
    Edwards, John T.
    Breinig, Tanja
    Wain-Hobson, Simon
    Meyerhans, Andreas
    Affiliation
    Institute of Numerical Mathematics, Russian Academy of Sciences ; University of Chester ; University of Chester ; University of the Saarland ; Unité de Rétrovirologie Moléculaire, Institut Pasteur ; University of the Saarland
    Publication Date
    2005-11-01
    
    Metadata
    Show full item record
    Abstract
    It has been previously shown that the majority of human immunodeficiency virus type 1 (HIV-1)-infected splenocytes can harbour multiple, divergent proviruses with a copy number ranging from one to eight. This implies that, besides point mutations, recombination should be considered as an important mechanism in the evolution of HIV within an infected host. To explore in detail the possible contributions of multi-infection and recombination to HIV evolution, the effects of major microscopic parameters of HIV replication (i.e. the point-mutation rate, the crossover number, the recombination rate and the provirus copy number) on macroscopic characteristics (such as the Hamming distance and the abundance of n-point mutants) have been simulated in silico. Simulations predict that multiple provirus copies per infected cell and recombination act in synergy to speed up the development of sequence diversity. Point mutations can be fixed for some time without fitness selection. The time needed for the selection of multiple mutations with increased fitness is highly variable, supporting the view that stochastic processes may contribute substantially to the kinetics of HIV variation in vivo.
    Citation
    Journal of General Virology, 86, 2005, pp. 3109-3118
    Publisher
    Society for General Microbiology / High Wire Press
    Journal
    Journal of General Virology
    URI
    http://hdl.handle.net/10034/67761
    DOI
    10.1099/vir.0.81138-0
    Additional Links
    http://vir.sgmjournals.org
    Type
    Article
    Language
    en
    Description
    This article is not available through ChesterRep.
    ISSN
    0022-1317
    1465-2099
    Sponsors
    This article was submitted to the RAE2008 for the University of Chester - Allied Health Professions and Studies.
    ae974a485f413a2113503eed53cd6c53
    10.1099/vir.0.81138-0
    Scopus Count
    Collections
    Mathematics

    entitlement

     
    DSpace software (copyright © 2002 - 2021)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.