Now showing items 1-20 of 273

    • Experimental Sound Mixing for The Well, a Short Film Made for Tablets

      Collins, Karen; Dockwray, Ruth (MIT Press - Journals, 2018-12)
    • Human adipose tissue-derived mesenchymal stem/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa

      Wood, Chelsea Rheannon; Al Dhahri, Douaa; Al Delfi, Ibtesam; Pickles, Neil Anthony; Sammons, Rachel L.; Worthington, Tony; Wright, Karina Theresa; Johnson, William Eustace Basil (Microbiology Society, 2018-12-01)
    • ‘Digital by Default’ and the ‘hard to reach’: Exploring solutions to digital exclusion in remote rural areas

      Williams, Fiona; Philip, Lorna; Farrington, John; Fairhurst, Gorry (SAGE Publications, 2016-09-30)
    • The crisis of democratic culture?

      Bendall, Mark J.; Robertson, Chris (Intellect, 2018-09-01)
    • Inhibitor clinical burden of disease: a comparative analysis of the CHESS data.

      Oladapo, Abiola O; email: Abiola.Oladapo@shire.com; Lu, Mei; Walsh, Shaun; O'Hara, Jamie; Kauf, Teresa L (2018-11-09)
      BACKGROUND:Patients with hemophilia and inhibitors generally face greater disease burden compared to patients without inhibitors. While raising awareness of relative burden may improve the standard of care for patients with inhibitors, comparative data are sparse. Analyzing data drawn from the Cost of Haemophilia across Europe - a Socioeconomic Survey (CHESS) study, the aim of this study was to compare the clinical burden of disease in patients with severe hemophilia with and without inhibitors. Hemophilia specialists (N = 139) across five European countries completed an online survey between January-April 2015, providing demographic, clinical and 12-month ambulatory/secondary care activity data for 1285 patients. Patients with hemophilia who currently presented with inhibitors and those who never had inhibitors were matched on baseline characteristics via propensity score matching. Outcomes were compared between the two cohorts using a paired t-test or Wilcoxon signed-rank or McNemar's test. RESULTS:The proportion of patients who currently presented with inhibitors was 4.5% (58/1285). Compared to PS-matched patients without inhibitors, patients with inhibitors experienced more than twice the mean annual number of bleeds (mean ± standard deviation, 8.29 ± 9.18 vs 3.72 ± 3.95; p < .0001) and joint bleeds (2.17 ± 1.90 vs 0.98 ± 1.15; p < .0001), and required more hemophilia-related (mean ± standard deviation, 1.79 ± 1.83 vs 0.64 ± 1.13) and bleed-related hospitalizations (1.86 ± 1.88 vs 0.81 ± 1.26), hemophilia-related consultations (9.30 ± 4.99 vs 6.77 ± 4.47), and outpatient visits (22.09 ± 17.77 vs 11.48 ± 16.00) (all, p < .001). More than one-half (53.5%) experienced moderate/severe pain necessitating medication compared to one-third (32.8%) of patients without inhibitors (p = .01). CONCLUSIONS:Patients with hemophilia and inhibitors exhibited greater clinical burden and higher resource utilization compared to their peers without inhibitors. Strategies for improving the standard of care may alleviate burden in this population.
    • In-depth synthetic, physicochemical and in vitro biological investigation of a new ternary V(IV) antioxidant material based on curcumin.

      Halevas, E; Papadopoulos, T A; Swanson, C H; Smith, G C; Hatzidimitriou, A; Katsipis, G; Pantazaki, A; Sanakis, I; Mitrikas, G; Ypsilantis, K; Litsardakis, G; Salifoglou, A; email: salif@auth.gr (2018-11-06)
      Curcumin is a natural product with a broad spectrum of beneficial properties relating to pharmaceutical applications, extending from traditional remedies to modern cosmetics. The biological activity of such pigments, however, is limited by their solubility and bioavailability, thereby necessitating new ways of achieving optimal tissue cellular response and efficacy as drugs. Metal ion complexation provides a significant route toward improvement of curcumin stability and biological activity, with vanadium being a representative such metal ion, amply encountered in biological systems and exhibiting exogenous bioactivity through potential pharmaceuticals. Driven by the need to optimally increase curcumin bioavailability and bioactivity through complexation, synthetic efforts were launched to seek out stable species, ultimately leading to the synthesis and isolation of a new ternary V(IV)-curcumin-(2,2'-bipyridine) complex. Physicochemical characterization (elemental analysis, FT-IR, Thermogravimetry (TGA), UV-Visible, NMR, ESI-MS, Fluorescence, X-rays) portrayed the solid-state and solution properties of the ternary complex. Pulsed-EPR spectroscopy, in frozen solutions, suggested the presence of two species, cis- and trans-conformers. Density Functional Theory (DFT) calculations revealed the salient features and energetics of the two conformers, thereby complementing EPR spectroscopy. The well-described profile of the vanadium species led to its in vitro biological investigation involving toxicity, cell metabolism inhibition in S. cerevisiae cultures, Reactive Oxygen Species (ROS)-suppressing capacity, lipid peroxidation, and plasmid DNA degradation. A multitude of bio-assays and methodologies, in comparison to free curcumin, showed that it exhibits its antioxidant potential in a concentration-dependent fashion, thereby formulating a bioreactivity profile supporting development of new efficient vanado-pharmaceuticals, targeting (extra)intra-cellular processes under (patho)physiological conditions. [Abstract copyright: Crown Copyright © 2018. Published by Elsevier Inc. All rights reserved.]
    • Connect 4: A Novel Paradigm to Elicit Positive and Negative Insight and Search Problem Solving.

      Hill, Gillian; Kemp, Shelly M (2018-10-25)
      Researchers have typically defined insight as a sudden new idea or understanding accompanied by an emotional feeling of Aha. Recently, examples of negative insight in everyday creative problem solving have been identified. These are seen as sudden and sickening moments of realization experienced as an Uh-oh rather than Aha. However, such experiences have yet to be explored from an experimental perspective. One barrier to doing so is that methods to elicit insight in the laboratory are constrained to positive insight. This study therefore aimed to develop a novel methodology that elicits both positive and negative insight solving, and additionally provides the contrasting experiences of analytic search solving in the same controlled conditions. The game of Connect 4 was identified as having the potential to produce these experiences, with each move representing a solving episode (where best to place the counter). Eighty participants played six games of Connect 4 against a computer and reported each move as being a product of positive search, positive insight, negative search or negative insight. Phenomenological ratings were then collected to provide validation of the experiences elicited. The results demonstrated that playing Connect 4 saw reporting of insight and search experiences that were both positive and negative, with the majority of participants using all four solving types. Phenomenological ratings suggest that these reported experiences were comparable to those elicited by existing laboratory methods focused on positive insight. This establishes the potential for Connect 4 to be used in future problem solving research as a reliable elicitation tool of insight and search experiences for both positive and negative solving. Furthermore, Connect 4 may be seen to offer more true to life solving experiences than other paradigms where a series of problems are solved working toward an overall superordinate goal rather than the presentation of stand-alone and un-related problems. Future work will need to look to develop versions of Connect 4 with greater control in order to fully utilize this methodology for creative problem solving research in experimental psychology and neuroscience contexts.
    • Finding the Forgotten: Motivating Military Veterans to Register with a Primary Healthcare Practice

      Finnegan, Alan; Jackson, Robin; Simpson, Robin (Oxford University Press (OUP), 2018-05-09)
    • Age-related differences when measuring political hypocrisy

      Prete, M. Irene; orcid: 0000-0001-9360-0475; Guido, Gianluigi; Pichierri, Marco; Harris, Phil (Wiley, 2018-04-16)
    • Body Part Removal: A Thematic Exploration of U.K. Homicide Offenses

      Almond, Louise; Pell, Connor; McManus, Michelle (SAGE Publications, 2018-11-28)
    • Stent Frame Movement Following Endovascular Aneurysm Sealing in the Abdominal Aorta

      Yafawi, Asma; orcid: 0000-0002-8390-9951; McWilliams, Richard G.; Fisher, Robert K.; England, Andrew; Karouki, Maria; Torella, Francesco (SAGE Publications, 2018-11-28)
    • Lay Female Devotional Lives in the Counter Reformation

      Hillman, Jennifer; email: j.hillman@chester.ac.uk (Brill, 2017-01-01)
    • Flood risk to commercial property

      Bhattacharya-Mis, Namrata; Lamond, Jessica; Montz, Burrell; Kreibich, Heidi; Wilkinson, Sara; Chan, Faith; Proverbs, David (Emerald, 2018-11-12)
    • Luther’s Legacy: Rethinking the Theology of Lay Discipleship 500 Years after the Reformation

      Graham, Elaine; email: e.graham@chester.ac.uk (Brill, 2017-09-23)
    • Regulating the Activities of Multinational Corporations in Nigeria: A Case for the African Union?

      Ekhator, Eghosa Osa; email: eghosaekhator@gmail.com (Brill, 2018-03-05)