• Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer

      Eccles, Suzanne A.; Aboagye, Eric O.; Ali, Simak; Anderson, Annie S.; Armes, Jo; Berditchevski, Fedor; Blaydes, Jeremy P.; Brennan, Keith; Brown, Nicola J.; Bryant, Helen E.; et al. (BioMed Central, 2013-10-01)
      Introduction: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem’ cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.
    • Health inequalities as a foundation for embodying knowledge within public health teaching: a qualitative study

      Mabhala, Mzwandile A.; University of Chester (BioMed Central, 2013-06-28)
      Introduction: Recent UK health policies identified nurses as key contributors to the social justice agenda of reducing health inequalities, on the assumption that all nurses understand and wish to contribute to public health. Following this policy shift, public health content within pre-registration nursing curricula increased. However, public health nurse educators (PHNEs) had various backgrounds, and some had limited formal public health training, or involvement in or understanding of policy required to contribute effectively to it. Their knowledge of this subject, their understanding and interpretation of how it could be taught, was not fully understood. Methodology This research aimed to understand how public health nurse educators’ professional knowledge could be conceptualised and to develop a substantive theory of their knowledge of teaching public health, using a qualitative data analysis approach. Qualitative in-depth semi-structured interviews (n=26) were conducted with eleven university-based PHNEs. Results Integrating public health into all aspects of life was seen as central to the knowing and teaching of public health; this was conceptualised as ‘embodying knowledge’. Participants identified the meaning of embodying knowledge for teaching public health as: (a) possessing a wider vision of health; (b) reflecting and learning from experience; and (c) engaging in appropriate pedagogical practices. Conclusion The concept of public health can mean different things to different people. The variations of meaning ascribed to public health reflect the various backgrounds from which the public health workforce is drawn. The analysis indicates that PHNEs are embodying knowledge for teaching through critical pedagogy, which involves them engaging in transformative, interpretive and integrative processes to refashion public health concepts; this requires PHNEs who possess a vision of what to teach, know how to teach, and are able to learn from experience. Their vision of public health is influenced by social justice principles in that health inequalities, socioeconomic determinants of health, epidemiology, and policy and politics are seen as essential areas of the public health curriculum. They believe in forms of teaching that achieve social transformation at individual, behavioural and societal levels, while also enabling learners to recognise their capacity to effect change.
    • Ethical issues in pedagogic research

      Regan, Julie-Anne; Baldwin, Moyra A.; Peters, Lisa; University of Chester (University of Bedfordshire, 2012-10)
      This paper explores the ethical issues identified by a research ethics committee (REC) over a three-year period. The REC is situated in a medium-sized univerity in the north west of England and deals exclusively with proposals for pedagogic research. The purpose of the research was to identify the nature and frequency of ethical concerns expressed by the REC, in order to improve guidance for future applicants. The most common concern was the lack, or inaccuracy, of the information provided to potential participants by which they were expected to make an informed decision about participation. Other concerns included the potential for bias, the lack of information provided to the REC, the provision for fair access by vulnerable groups and undue influence on voluntary particpation. The paper concludes that the potential risks of practitioners researching their own students are not given due consideration by many applicats. In particular the potential threats to valid informed consent are identified. Implications for improving the relationship between researchers and RECs are discussed, as is the guidance for applicants.
    • Examining the workings of a late nineteenth century provincial press conglomerate: Frederick Edward Roe and his newspapers

      Peters, Lisa; University of Chester (2012-07-12)
      This presentation discuss four newspapers located in north Wales and the Marches owned by Frederick Edward Roe between 1880 and 1887. It analyses the relationship between the four titles and the extent to which they shared content, advertising, and staff.
    • Meeting the needs of distance learners: The creation of an interactive resource pack for library inductions

      Gleeson, Charlotte; University of Chester (2012-04-12)
      Within the UK, higher education is increasingly becoming more competitive, particularly with the arrival of increased fees from 2012. As a result, over the past few years the University of Chester has ran programmes in other countries including Dublin and Mumbai to raise its research profile and meet the needs of the market. Students on these distance learner programmes have the same rights with regards to online library resources as those studying at Chester. One of the main problems that has arisen from this has been how to induct the students and show them the wealth of online library resources available to them. The presentation will focus on an initiative at the University of Chester that looked at developing a new approach to inducting students at a distance. In September 2011, the Applied Sciences and Social Science library subject team at the University created a resource pack for students on distance learner programmes in other countries with an aim to improve the student experience during induction. The resources pack consisted of an interactive tutorial DVD and a resource CD containing information on how to access the library resources the students would need for their course. This pack replaced previous methods of induction such as printed hand-outs and workbooks. It was hoped it would be a more personable and accessible method of inducting the students into the library at a distance. The presentation will examine the rationale behind creating the resource pack and will look at the benefits and challenges involved in creating the content including compatibility issues with the format of the DVD. It will consider the feedback received from students regarding the resources pack and areas for potentially developing the project in the future.
    • Still Wrexham's longest running newspaper - the Wrexham Advertiser

      Peters, Lisa; University of Chester (Bridge Books, 2012-03)
      This article discuss the Wrexham Advertiser - a newspaper which ran from 1850 to 1957.
    • Kindle project at the University of Chester

      McLean, Fiona; Shepherd, Joanna; University of Chester (SCONUL, 2012)
      Towards the end of 2010, Learning and Information Services (LIS) at the University of Chester decided to undertake a pilot project which explored how useful e-readers are in a university setting and if they could help to resolve issues about resource availability.
    • Ethical issues in pedagogic research

      Regan, Julie-Anne; Peters, Lisa; Baldwin, Moyra A.; University of Chester (2011-12-06)
      This presentation discusses the ethical issues identified by a research ethics committee (REC) over a three year period. The REC deals exclusively with proposals for pedagogic research. The purpose of the research was to identify the nature and frequency of ethical concerns expressed by the REC, in order to improve guidance for future applicants.
    • Museum collections: Management, conservation and presentation

      Peters, Lisa; McKay, Ian S. H.; University of Chester (2011-09-21)
    • The student enrichment programme: An inter-professional collaboration

      Greenwood, Joanne M.; Thomas, Helen; Sinnott, Celia; Headon, Stephanie; Rogers, Lisa; University of Chester (2011-06-15)
      This presentation discusses how Learning Support Unit, Learning Information Services, Careers and Employability work together with academic lecturers to deliver skills sessions to nursing students.
    • Politics, publishing and personalities: Wrexham newspapers, 1848-1914

      Peters, Lisa; University of Chester (University of Chester Press, 2011-04)
      This book gives a unique insight into the worls of provincial newspaper publishing in a North Wales town during the Victorian and Edwardian eras. Wrexham's position on the Welsh border meant that its local newspapers had to compete with those from Shropshire, Cheshire, and the rest of North Wales and this rivalry, together with differing political allegiances, often led to conflict between proprietors in the effort to gain the highest circulation. The book draws together the batttles to establish succcessful titles against the backdrop of British and Welsh politics and reveals the personalities involved in this microcosm of local society.
    • Online screencasting tutorials: A way forward for legal resources training?

      Peters, Lisa; University of Chester (Cambridge University Press, 2011)
      This journal articles discusses the using screencasting (video tutorials) in legal resources training.
    • Information literacy

      Fiander, Wendy; University of Chester (SAGE, 2011)
      This book chapter discusses the importance of developing information literacy skills in healthcare students.
    • Darzi's vision becomes a reality

      Holly, Chris; University of Chester (Royal College of Midwives, 2009-12)
      This articles discusses the new webside NHS Evidence - which aims to provide easy access to a comphrehensive evidence base for healthcare professionals.
    • Using the CLA scanning licence to offer 24x7 access to in-demand book chapters and journal articles at the University of Chester

      Peters, Lisa; University of Chester (SCONUL, 2009-12)
      This article discusses the implementation and operation of the CLA scanning licence at the University of Chester library.
    • Selling the news: Distributing Wrexham's newspapers, 1850-1914

      Peters, Lisa; Skinner, Katherine; University of Chester (Oak Knoll Press & The British Library, 2009-07)
      This book chapter discusses how Wrexham's newspapers developed a reliable distribution service through north and mid Wales and parts of Cheshire and Shropshire. The role of agents and how their location reflected a newspaper's circulation area is particuarly discussed.
    • "Welsh obscurity to notoriety" - Lloyd George, the Boer War, and the North Wales Press

      Peters, Lisa; University of Chester (Oak Knoll Press & The British Library, 2008-05)
      This book chapter discusses the actions of David Lloyd George (MP for the Carnarvon Boroughs and future Prime Minister) during the Boer War of 1899-1902 as seen by the local North Wales press, The chapter seeks to cast light upon local views of Lloyd George's stance and explain why he was re-elected with an increased majority in the 1900 general election, despite accusations of treason. Newspapers analysed include the Carnarvon & Denbigh Herald, the North Wales Times, Yr Herald Cymraeg, the North Wales Chronicle, the Wrexham Advertiser, the North Wales Guardian, the Holyhead Mail and Anglesey Herald, and Y Baner ac Amserau Cymru.
    • Structural characterisation of two pharmaceutically important steroids by solid-state NMR

      Othman, Abdullah; Harris, Robin K.; Hodgkinson, Paul; Christopher, Elizabeth A.; Lancaster, Robert W.; University of Durham ; University of Durham ; University of Durham ; University of Chester/University of Durham ; University of Durham (Royal Society of Chemistry/Centre National de la Recherche Scientifique, 2008)
      Several crystal modifications of two steroids (androsterone and beclomethasone dipropionate) have been characterised by solid-state NMR methods, and the chemical shifts between the different forms compared. The gradual loss of water from androsterone hemihydrate has been monitored by XRPD. The crystal structures are discussed in relation to the NMR data. That of the beclomethasone dipropionate ethyl acetate solvate has been determined for the first time. It is found that there are clear channels containing the ethyl acetate molecules, which are apparently not incorporated by hydrogen bonding. Carbon-13 CPMAS spectra with long contact times and MAS proton spectra are used to show the mobility of ethyl acetate molecules in the BDP solvate. The second-order effect of chlorine on the 13C spectrum of beclomethasone dipropionate monohydrate has been explored by varying the applied magnetic field.
    • Evaluating the Cephalonia method of library induction

      Peters, Lisa; Brown, Judith; Davies, Eric; Hultum, Sue; Thompson, Marion; Thomas, Pam; Williams, Anne; University of Chester (SCONUL, 2007-12)
      This article discusses the results of a survey carried out at the University of Chester library into student feedback of the Cephalonia method of library induction.
    • PDP in the curriculum - how far have we come?

      Done, Judith; Univesity of Chester (2007-06-01)
      This presentation discusses the extent to which the University of Chester's revised academic framework will raise the profile of personal development portfolios and career development learning. The potential impact on the student experience will also be explored.