• Pioneering British women chemists: their lives and contributions

      Badrock, Gill (Informa UK Limited, 2020-05-31)
    • Pioneering British women chemists: their lives and contributions

      Badrock, Gill (Informa UK Limited, 2020-05-31)
    • Pirfenidone in heart failure with preserved ejection fraction: a randomized phase 2 trial.

      Lewis, Gavin A; orcid: 0000-0001-6754-836X; Dodd, Susanna; Clayton, Dannii; orcid: 0000-0003-3535-3466; Bedson, Emma; Eccleson, Helen; Schelbert, Erik B; orcid: 0000-0003-0356-4437; Naish, Josephine H; Jimenez, Beatriz Duran; Williams, Simon G; Cunnington, Colin; et al. (2021-08-12)
      In heart failure with preserved ejection fraction (HFpEF), the occurrence of myocardial fibrosis is associated with adverse outcome. Whether pirfenidone, an oral antifibrotic agent without hemodynamic effect, is efficacious and safe for the treatment of HFpEF is unknown. In this double-blind, phase 2 trial ( NCT02932566 ), we enrolled patients with heart failure, an ejection fraction of 45% or higher and elevated levels of natriuretic peptides. Eligible patients underwent cardiovascular magnetic resonance and those with evidence of myocardial fibrosis, defined as a myocardial extracellular volume of 27% or greater, were randomly assigned to receive pirfenidone or placebo for 52 weeks. Forty-seven patients were randomized to each of the pirfenidone and placebo groups. The primary outcome was change in myocardial extracellular volume, from baseline to 52 weeks. In comparison to placebo, pirfenidone reduced myocardial extracellular volume (between-group difference, -1.21%; 95% confidence interval, -2.12 to -0.31; P = 0.009), meeting the predefined primary outcome. Twelve patients (26%) in the pirfenidone group and 14 patients (30%) in the placebo group experienced one or more serious adverse events. The most common adverse events in the pirfenidone group were nausea, insomnia and rash. In conclusion, among patients with HFpEF and myocardial fibrosis, administration of pirfenidone for 52 weeks reduced myocardial fibrosis. The favorable effects of pirfenidone in patients with HFpEF will need to be confirmed in future trials. [Abstract copyright: © 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.]
    • Plant-Morphing Strategies and Plant-Inspired Soft Actuators Fabricated by Biomimetic Four-Dimensional Printing: A Review

      Ren, Luquan; Li, Bingqian; Wang, Kunyang; Zhou, Xueli; Song, Zhengyi; Ren, Lei; email: lei.ren@manchester.ac.uk; Liu, Qingping; email: liuqp@jlu.edu.cn (Frontiers Media S.A., 2021-05-04)
      For prey, seeding, and protection, plants exhibit ingenious adaptive motions that respond autonomously to environmental stimuli by varying cellular organization, anisotropic orientation of cellulose fibers, mechanical instability design, etc. Notably, plants do not leverage muscle and nerves to produce and regulate their motions. In contrast, they harvest energy from the ambient environment and compute through embodied intelligence. These characteristics make them ideal candidates for application in self-morphing devices. Four-dimensional (4D) printing is a bottom-up additive manufacturing method that builds objects with the ability to change shape/properties in a predetermined manner. A versatile motion design catalog is required to predict the morphing processes and final states of the printed parts. This review summarizes the morphing and actuation mechanisms of plants and concludes with the recent development of 4D-printed smart materials inspired by the locomotion and structures of plant systems. We provide analyses of the challenges and our visions of biomimetic 4D printing, hoping to boost its application in soft robotics, smart medical devices, smart parts in aerospace, etc.
    • Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout

      Webb, Lauren M; orcid: 0000-0002-1903-7570; Phythian-Adams, Alexander T; orcid: 0000-0003-0426-6562; Costain, Alice H; Brown, Sheila L; Lundie, Rachel J; Forde-Thomas, Josephine; Cook, Peter C; orcid: 0000-0002-5208-4985; Jackson-Jones, Lucy H; orcid: 0000-0003-0608-8966; Marley, Angela K; Smits, Hermelijn H; orcid: 0000-0001-9279-2890; et al. (2021-08-30)
      Plasmacytoid dendritic cells (pDCs) are potent producers of type I IFN (IFN-I) during viral infection and respond to IFN-I in a positive feedback loop that promotes their function. IFN-I shapes dendritic cell responses during helminth infection, impacting their ability to support Th2 responses. However, the role of pDCs in type 2 inflammation is unclear. Previous studies have shown that pDCs are dispensable for hepatic or splenic Th2 responses during the early stages of murine infection with the trematode at the onset of parasite egg laying. However, during infection, an ongoing Th2 response against mature parasite eggs is required to protect the liver and intestine from acute damage and how pDCs participate in immune responses to eggs and adult worms in various tissues beyond acute infection remains unclear. We now show that pDCs are required for optimal Th2 cytokine production in response to eggs in the intestinal-draining mesenteric lymph nodes throughout infection and for egg-specific IFN-γ at later time points of infection. Further, pDC depletion at chronic stages of infection led to increased hepatic and splenic pathology as well as abrogated Th2 cell cytokine production and activation in the liver. In vitro, mesenteric lymph node pDCs supported Th2 cell responses from infection-experienced CD4 T cells, a process dependent on pDC IFN-I responsiveness, yet independent of Ag. Together, these data highlight a previously unappreciated role for pDCs and IFN-I in maintaining and reinforcing type 2 immunity in the lymph nodes and inflamed tissue during helminth infection. [Abstract copyright: Copyright © 2021 The Authors.]
    • Plutopia. Nuclear Families, Atomic Cities, and the Great Soviet and American Plutonium Disasters, by Kate Brown. Oxford: Oxford University Press; 2013.

      Wakeford, Richard; email: richard.wakeford@manchester.ac.uk; email: richard.wakeford@gmail.com (2021-01-01)
    • Politics, publishing and personalities: Wrexham newspapers, 1848-1914

      Peters, Lisa; University of Chester (University of Chester Press, 2011-04)
      This book gives a unique insight into the worls of provincial newspaper publishing in a North Wales town during the Victorian and Edwardian eras. Wrexham's position on the Welsh border meant that its local newspapers had to compete with those from Shropshire, Cheshire, and the rest of North Wales and this rivalry, together with differing political allegiances, often led to conflict between proprietors in the effort to gain the highest circulation. The book draws together the batttles to establish succcessful titles against the backdrop of British and Welsh politics and reveals the personalities involved in this microcosm of local society.
    • Polygenic risk score opportunities for early detection and prevention strategies in endometrial cancer

      O’Mara, Tracy A.; Crosbie, Emma J.; orcid: 0000-0003-0284-8630; email: emma.crosbie@manchester.ac.uk (Nature Publishing Group UK, 2020-07-06)
      Summary: Recent large-scale genetic studies, particularly genome-wide association studies (GWAS), have emphasised the importance of common genetic variation in endometrial cancer susceptibility. Although each of these variants only confer modest effects on endometrial cancer risk, together they are likely to explain a substantial amount of the familial relative risk of the disease. Therefore, methods to combine genetic risk variants, such as polygenic risk scores (PRS) have gained traction as an attractive method for individualised risk prediction and management. Here, we discuss the benefits of a PRS for endometrial cancer and considerations required for clinical implementation.
    • Pore network and Darcy scale modelling of DNAPL remediation using ethanol flushing: Study of physical properties in DNAPL remediation.

      Aminnaji, Morteza; Yakşi, Korcan; Copty, Nadim K; Niasar, Vahid J; Babaei, Masoud; email: masoud.babaei@manchester.ac.uk (2021-09-04)
      Co-solvent flushing into contaminated soils is one of the most effective techniques for Dense Non-Aqueous Phase Liquid (DNAPL) remediation. In addition to the increase of DNAPL solubility, co-solvents (e.g. ethanol) can alter the viscosity and density of aqueous phase and diffusion coefficient of solute. Any changes in these parameters can change the flow behaviour and alter the upscaled DNAPL mass transfer coefficient which is a key parameter controlling soil and groundwater remediation at Darcy-scale. While numerous studies have investigated DNAPL remediation using co-solvents at the Darcy scale, pore-scale modelling of co-solvent enhanced DNAPL remediation has not been well investigated. In this work, a three-dimensional pore-network model was developed to simulate the 1,2-dichlorobenzene (DCB) remediation experiments using ethanol-water flushing solution. The model simulates the effect of changes in solubility, viscosity, density, and diffusion coefficient during co-solvent flushing of the DNAPL. The results of pore network modelling for ethanol-water flushing for the DCB remediation were also validated using the experimental data. In addition to pore-scale modelling, a continuum scale modelling (Darcy-scale) was used for the DCB remediation using ethanol-water flushing. The results of both pore network and continuum scale modelling demonstrated that the ethanol content and flushing velocity influence the interphase mass transfer and DNAPL dissolution process. The results indicated while the mass transfer coefficient decreased in the presence of ethanol, the process of NAPL remediation was improved due to the substantial increase of solubility in the presence of co-solvent. The large scale modelling showed that NAPL bank can be formed in the front of ethanol-water mixture flushing. [Abstract copyright: Copyright © 2021 Elsevier B.V. All rights reserved.]
    • Portable through Bottle SORS for the Authentication of Extra Virgin Olive Oil

      Varnasseri, Mehrvash; email: Mehrvash.Varnasseri@liverpool.ac.uk; Muhamadali, Howbeer; email: Howbeer.Muhamad-Ali@liverpool.ac.uk; Xu, Yun; email: Yun.Xu@liverpool.ac.uk; Richardson, Paul I. C.; email: P.Richardson2@liverpool.ac.uk; Byrd, Nick; email: nick.byrd@campdenbri.co.uk; Ellis, David I.; orcid: 0000-0002-7633-7019; email: D.Ellis@manchester.ac.uk; Matousek, Pavel; email: pavel.matousek@stfc.ac.uk; Goodacre, Royston; orcid: 0000-0003-2230-645X; email: Roy.Goodacre@liverpool.ac.uk (MDPI, 2021-09-09)
      The authenticity of olive oil has been a significant long-term challenge. Extra virgin olive oil (EVOO) is the most desirable of these products and commands a high price, thus unscrupulous individuals often alter its quality by adulteration with a lower grade oil. Most analytical methods employed for the detection of food adulteration require sample collection and transportation to a central laboratory for analysis. We explore the use of portable conventional Raman and spatially-offset Raman spectroscopy (SORS) technologies as non-destructive approaches to assess the adulteration status of EVOO quantitatively and for SORS directly through the original container, which means that after analysis the bottle is intact and the oil would still be fit for use. Three sample sets were generated, each with a different adulterant and varying levels of chemical similarity to EVOO. These included EVOO mixed with sunflower oil, pomace olive oil, or refined olive oil. Authentic EVOO samples were stretched/diluted from 0% to 100% with these adulterants and measured using two handheld Raman spectrometers (excitation at 785 or 1064 nm) and handheld SORS (830 nm). The PCA scores plots displayed clear trends which could be related to the level of adulteration for all three mixtures. Conventional Raman (at 785 or 1064 nm) and SORS (at 830 nm with a single spatial offset) conducted in sample vial mode resulted in prediction errors for the test set data ranging from 1.9–4.2% for sunflower oil, 6.5–10.7% for pomace olive oil and 8.0–12.8% for refined olive oil; with the limit of detection (LOD) typically being 3–12% of the adulterant. Container analysis using SORS produced very similar results: 1.4% for sunflower, 4.9% for pomace, and 10.1% for refined olive oil, with similar LODs ranging from 2–14%. It can be concluded that Raman spectroscopy, including through-container analysis using SORS, has significant potential as a rapid and accurate analytical method for the non-destructive detection of adulteration of extra virgin olive oil.
    • Positive Selection Inhibits Plasmid Coexistence in Bacterial Genomes.

      Carrilero, Laura; Kottara, Anastasia; Guymer, David; Harrison, Ellie; orcid: 0000-0002-2050-4631; Hall, James P J; Brockhurst, Michael A; orcid: 0000-0003-0362-820X; email: michael.brockhurst@manchester.ac.uk (2021-05-11)
      Plasmids play an important role in bacterial evolution by transferring niche-adaptive functional genes between lineages, thus driving genomic diversification. Bacterial genomes commonly contain multiple, coexisting plasmid replicons, which could fuel adaptation by increasing the range of gene functions available to selection and allowing their recombination. However, plasmid coexistence is difficult to explain because the acquisition of plasmids typically incurs high fitness costs for the host cell. Here, we show that plasmid coexistence was stably maintained without positive selection for plasmid-borne gene functions and was associated with compensatory evolution to reduce fitness costs. In contrast, with positive selection, plasmid coexistence was unstable despite compensatory evolution. Positive selection discriminated between differential fitness benefits of functionally redundant plasmid replicons, retaining only the more beneficial plasmid. These data suggest that while the efficiency of negative selection against plasmid fitness costs declines over time due to compensatory evolution, positive selection to maximize plasmid-derived fitness benefits remains efficient. Our findings help to explain the forces structuring bacterial genomes: coexistence of multiple plasmids in a genome is likely to require either rare positive selection in nature or nonredundancy of accessory gene functions among the coexisting plasmids. Bacterial genomes often contain multiple coexisting plasmids that provide important functions like antibiotic resistance. Using lab experiments, we show that such plasmid coexistence within a genome is stable only in environments where the function they encode is useless but is unstable if the function is useful and beneficial for bacterial fitness. Where competing plasmids perform the same useful function, only the most beneficial plasmid is kept by the cell, a process that is similar to competitive exclusion in ecological communities. This process helps explain how bacterial genomes are structured: bacterial genomes expand in size by acquiring multiple plasmids when selection is relaxed but subsequently contract during periods of strong selection for the useful plasmid-encoded function. [Abstract copyright: Copyright © 2021 Carrilero et al.]
    • Post-irradiation surface viscoelastic integrity of photo-polymerized resin-based composites.

      Algamaiah, Hamad; email: dr.algamaiah@gmail.com; Watts, David C; email: david.watts@manchester.ac.uk (2021-09-27)
      A class of ultra-rapid-cure resin-based composites (RBCs) exhibited immediate post-irradiation surface viscoelastic integrity using an indentation-creep/recovery procedure. The aim of this study was to determine whether such behavior is more generally characteristic of a wider range of RBCs. Eight representative RBCs were selected based on different clinical categories: three bulkfills (OBF, Filtek One Bulk Fill; VBF, Venus Bulkfill; EBF, Estelite Bulkfill), three conventional non-flowables (XTE, Filtek Supreme XTE; GSO, GrandioSo; HRZ, Harmonize) and conventional flowables (XTF, Filtek Supreme XTE Flow; GSF, GrandioSo Flow). Stainless steel split molds were used to fabricate cylindrical specimens (4mm (dia)×4mm). These were irradiated (1.2W/cm ) for 20s on the top surface. Post-irradiation specimens (n=3), within their molds, were centrally loaded with a flat-ended 1.5mm diameter indenter under 14MPa stress: either immediately (<2min) or after 24h delayed indentation. Stress was maintained for 2h, then - after removal - recovery measurements continued for a further 2h. Indentation depth (%) versus time was measured continuously to an accuracy of <0.1μm. Data were analyzed by One-way ANOVA and Tukey post-hoc tests (α=0.05). Time-dependent viscoelastic indentation was observed for all RBCs. For immediate indentation, the maximum indentation range was 1.43-4.92%, versus 0.70-2.22% for 24h delayed indentation. Following 2h recovery, the residual indentation range was 0.86-3.58% after immediate indentation, reducing to 0.22-1.27% for delayed indentation. The greatest immediate indentation was shown by VBF followed by XTF and GSF. OBF, HRZ, XTE and GSO had significantly lower indentations (greater hardness). XTE showed a significantly reduced indentation maximum compared to OBF (p<0.05). Indentations delayed until 24h post-irradiation were reduced (p<0.05) for most materials. The indentation-creep methodology effectively characterized resin-based composites within several categories. Viscoelastic properties evaluated by the indentation-creep method confirmed that highly filled RBCs were more resistant to indentation. Indentations were reduced after 24h post-irradiation due to further matrix-network development. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]
    • Postcolonial social drama: The case of Brazilian dentists in Portugal

      Torresan, Angela; orcid: 0000-0001-8247-4979; email: angela.torresan@manchester.ac.uk (SAGE Publications, 2021-04-08)
      By the late 1990s, when I was conducting ethnographic fieldwork research in Lisbon, the ‘dentists’ case’ had become a familiar trope for the presence of Brazilian immigrants in Portugal. Although it involved a small group of Brazilian and Portuguese professionals, it gained visibility in the media of both countries, escalating into a political and diplomatic quarrel, and culminating in the amendment of the 1966 Cultural Accord. I use Victor Turner’s concept of social drama to address the case as a chapter in the cyclical pattern of connection and disconnection of postcolonial Luso-Brazilian relationships. Drawing from a recent discussion on the concept of cosmopolitanism in migration studies, I employ the idea of postcolonial sociabilities to help explore the seemingly inherent ambiguities in the relationship between Brazilians and Portuguese.
    • Practical Demonstration of a Hybrid Model for Optimising the Reliability, Risk, and Maintenance of Rolling Stock Subsystem

      Appoh, Frederick; orcid: 0000-0003-4228-5799; email: frederick.appoh@manchester.ac.uk; Yunusa-Kaltungo, Akilu; orcid: 0000-0001-5138-3783; Sinha, Jyoti Kumar; orcid: 0000-0001-9202-1789; Kidd, Moray; orcid: 0000-0003-4185-5788 (Springer Berlin Heidelberg, 2021-05-11)
      Abstract: Railway transport system (RTS) failures exert enormous strain on end-users and operators owing to in-service reliability failure. Despite the extensive research on improving the reliability of RTS, such as signalling, tracks, and infrastructure, few attempts have been made to develop an effective optimisation model for improving the reliability, and maintenance of rolling stock subsystems. In this paper, a new hybrid model that integrates reliability, risk, and maintenance techniques is proposed to facilitate engineering failure and asset management decision analysis. The upstream segment of the model consists of risk and reliability techniques for bottom-up and top-down failure analysis using failure mode effects and criticality analysis and fault tree analysis, respectively. The downstream segment consists of a (1) decision-making grid (DMG) for the appropriate allocation of maintenance strategies using a decision map and (2) group decision-making analysis for selecting appropriate improvement options for subsystems allocated to the worst region of the DMG map using the multi-criteria pairwise comparison features of the analytical hierarchy process. The hybrid model was illustrated through a case study for replacing an unreliable pneumatic brake unit (PBU) using operational data from a UK-based train operator where the frequency of failures and delay minutes exceeded the operator’s original target by 300% and 900%, respectively. The results indicate that the novel hybrid model can effectively analyse and identify a new PBU subsystem that meets the operator’s reliability, risk, and maintenance requirements.
    • Pre- and postoperative need for pituitary hormone replacement in non-adenomatous sellar and parasellar lesions: importance of the sellar encroachment score

      Waqar, Mueez; orcid: 0000-0002-7848-6237; email: mueez.waqar@manchester.ac.uk; Rampersad, Shiva; Bennett, David; Kearney, Tara; Gnanalingham, Kanna K.; email: kanna.gnanalingham@srft.nhs.uk (Springer Vienna, 2020-06-06)
      Abstract: Background: Pre-/postoperative pituitary endocrine deficiencies in patients with sellar/parasellar non-adenomatous lesions are poorly described and studies have not considered the effect of sellar invasion on endocrine outcome. The aim of this study was to relate the need for pituitary hormone replacement pre-/postoperatively, with sellar invasion, in non-adenomatous sellar/parasellar lesions. Methods: Single-centre review of adults with histologically confirmed non-adenomatous sellar/parasellar lesion and follow-up ≥ 3 months or until postop radiotherapy. Pituitary dysfunction was defined by hormone replacement. The sellar encroachment score (0–6) was calculated as the sum of the thirds of radiological encroachment into the sellar region in the coronal and sagittal planes. Multivariate analysis with binary logistic regression was used to determine factors associated with pituitary hormone replacement. Results: One hundred and seventeen patients were included with a median age of 49 years (range 16–84 years) and median follow-up of 13 months. Surgery was trans-sphenoidal (53%), trans-cranial (36%) or a combination (11%). The commonest histology types were meningioma (n = 33, 28%) and craniopharyngioma (n = 20, 17%). The median sellar encroachment score was 6 (range 0–6). Most (n = 86, 74%) did not require pituitary hormone replacement preoperatively. The need for pituitary hormones increased after surgery in 41 (35%) patients. In multivariate analysis, the sellar encroachment score was the only factor predictive of pre- (OR = 2.6, 95% CI = 1.2–5.5; p = 0.01) and postoperative risk of new pituitary hormone replacement (OR = 4.1, 95% CI = 1.7–10.1, p = 0.002). Conclusion: A significant proportion of these patients present with need for pituitary hormone replacement that may worsen postoperatively. The degree of sellar encroachment is predictive of pituitary hormone replacement status pre-/postoperatively.
    • Pre-treatment inflammatory parameters predict survival from endometrial cancer: A prospective database analysis.

      Njoku, Kelechi; Ramchander, Neal C; Wan, Y Louise; Barr, Chloe E; Crosbie, Emma J; email: emma.crosbie@manchester.ac.uk (2021-11-18)
      Inflammation predisposes to tumorigenesis by damaging DNA, stimulating angiogenesis and potentiating pro-proliferative and anti-apoptotic processes. The aim of this study was to investigate whether pre-treatment biomarkers of systemic inflammation are associated with survival outcomes in endometrial cancer. Women with endometrial cancer were recruited to a prospective database study. Pre-treatment systemic markers of inflammation, including C-reactive protein (CRP), Glasgow Prognostic Score and lymphocyte-based ratios [neutrophil-lymphocyte ratio (NMR), monocyte-lymphocyte ratio (MLR), systemic immune-inflammation index (SII)], were analysed in relation to overall, endometrial cancer-specific and recurrence-free survival using Kaplan-Meier estimation and multivariable Cox regression. In total, 522 women of mostly White British ethnicity, with a median age of 66 years (interquartile range (IQR), 56, 73) and BMI of 32 kg/m (IQR 26, 39) were included in the analysis. Most had low-grade (67.2%), early-stage (85.4% stage I/II), endometrioid (74.5%) tumors. Women with pre-treatment CRP ≥5.5 mg/L had a 68% increase in overall (adjusted HR = 1.68, 95% CI 1.00-2.81, p = 0.049) and a two-fold higher cancer-specific mortality risk than those with CRP <5.5 mg/L (adjusted HR = 2.04, 95%CI 1.03-4.02, p = 0.04). Absolute lymphocyte count, NLR, MLR and SII were associated with adverse clinico-pathologic factors, but not overall, cancer-specific or recurrence-free survival in the multivariable analysis. If confirmed in an independent cohort, CRP may offer a simple, low-cost test to refine pre-treatment risk assessment and guide personalised care in endometrial cancer. Our participants were mostly of White British ethnicity and further studies are needed to confirm the utility of CRP as a prognostic biomarker in other populations. [Abstract copyright: Copyright © 2021. Published by Elsevier Inc.]
    • Predicting new protein conformations from molecular dynamics simulation conformational landscapes and machine learning

      Jin, Yiming; Johannissen, Linus O.; email: linus.johannissen@manchester.ac.uk; Hay, Sam; orcid: 0000-0003-3274-0938; email: sam.hay@manchester.ac.uk (John Wiley & Sons, Inc., 2021-03-03)
      Abstract: Molecular dynamics (MD) simulations are a popular method of studying protein structure and function, but are unable to reliably sample all relevant conformational space in reasonable computational timescales. A range of enhanced sampling methods are available that can improve conformational sampling, but these do not offer a complete solution. We present here a proof‐of‐principle method of combining MD simulation with machine learning to explore protein conformational space. An autoencoder is used to map snapshots from MD simulations onto a user‐defined conformational landscape defined by principal components analysis or specific structural features, and we show that we can predict, with useful accuracy, conformations that are not present in the training data. This method offers a new approach to the prediction of new low energy/physically realistic structures of conformationally dynamic proteins and allows an alternative approach to enhanced sampling of MD simulations.
    • Predicting presenteeism using measures of health status.

      Jones, Cheryl; orcid: 0000-0002-3024-225X; email: cheryl.jones@manchester.ac.uk; Payne, Katherine; orcid: 0000-0002-3938-4350; Thompson, Alexander; Verstappen, Suzanne M M; orcid: 0000-0001-6181-0646 (2021-07-27)
      To identify whether it is feasible to develop a mapping algorithm to predict presenteeism using multiattribute measures of health status. Data were collected using a bespoke online survey in a purposive sample (n = 472) of working individuals with a self-reported diagnosis of Rheumatoid arthritis (RA). Survey respondents were recruited using an online panel company (ResearchNow). This study used data captured using two multiattribute measures of health status (EQ5D-5 level; SF6D) and a measure of presenteeism (WPAI, Work Productivity Activity Index). Statistical correlation between the WPAI and the two measures of health status (EQ5D-5 level; SF6D) was assessed using Spearman's rank correlation. Five regression models were estimated to quantify the relationship between WPAI and predict presenteeism using health status. The models were specified based in index and domain scores and included covariates (age; gender). Estimated and observed presenteeism were compared using tenfold cross-validation and evaluated using Root mean square error (RMSE). A strong and negative correlation was found between WPAI and: EQ5D-5 level and WPAI (r = - 0.64); SF6D (r =- 0.60). Two models, using ordinary least squares regression were identified as the best performing models specifying health status using: SF6D domains with age interacted with gender (RMSE = 1.7858); EQ5D-5 Level domains and age interacted with gender (RMSE = 1.7859). This study provides indicative evidence that two existing measures of health status (SF6D and EQ5D-5L) have a quantifiable relationship with a measure of presenteeism (WPAI) for an exemplar application of working individuals with RA. A future study should assess the external validity of the proposed mapping algorithms. [Abstract copyright: © 2021. The Author(s).]