• Taking the pain out of network induction: Using INFORMS to induct new first year students

      Fiander, Wendy; Peters, Lisa; Sinclair, Colin (SCONUL, 2003)
      In September 2003, Learning Resources at University College Chester used the JISC-funded INFORMS tutorial for student induction into the computer network. The article comments on how the INFORMS computer induction tutorial was developed at Chester, how it was used, and plans for future developments.
    • Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1.

      Gough, Rosemarie E; Jones, Matthew C; Zacharchenko, Thomas; Le, Shimin; Yu, Miao; Jacquemet, Guillaume; Muench, Ste P; Yan, Jie; Humphries, Jonathan D; Jørgensen, Claus; et al. (2021-06-09)
      Talin (TLN1) is a mechanosensitive component of adhesion complexes that directly couples integrins to the actin cytoskeleton. In response to force, talin undergoes switch-like behavior of its multiple rod domains that modulate interactions with its binding partners. Cyclin-dependent kinase-1 (CDK1) is a key regulator of the cell cycle, exerting its effects through synchronized phosphorylation of a large number of protein targets. CDK1 activity maintains adhesion during interphase, and its inhibition is a prerequisite for the tightly choreographed changes in cell shape and adhesion that are required for successful mitosis. Using a combination of biochemical, structural and cell biological approaches, we demonstrate a direct interaction between talin and CDK1 that occurs at sites of integrin-mediated adhesion. Mutagenesis demonstrated that CDK1 contains a functional talin-binding LD motif, and the binding site within talin was pinpointed to helical bundle R8. Talin also contains a consensus CDK1 phosphorylation motif centered on S1589, a site shown to be phosphorylated by CDK1 in vitro. A phosphomimetic mutant of this site within talin lowered the binding affinity of the cytoskeletal adaptor KANK and weakened the response of this region to force as measured by single molecule stretching, potentially altering downstream mechanotransduction pathways. The direct binding of the master cell cycle regulator CDK1 to the primary integrin effector talin represents a coupling of cell proliferation and cell adhesion machineries, and thereby indicates a mechanism by which the microenvironment can control cell division in multicellular organisms. [Abstract copyright: Crown Copyright © 2021. Published by Elsevier Inc. All rights reserved.]
    • Tamaglitchi

      Collins, Karen; Dockwray, Ruth (ACM, 2018-09-12)
    • Telling Reproductive Stories: Social Scripts, Relationality and Donor Conception

      Nordqvist, Petra; email: petra.nordqvist@manchester.ac.uk (SAGE Publications, 2021-01-12)
      Storytelling is a fundamental part of human interaction; it is also deeply social and political in nature. In this article, I explore reproductive storytelling as a phenomenon of sociological consequence. I do so in the context of donor conception, which used to be managed through secrecy but where children are now perceived ‘to have the right’ to know about their genetic origins. I draw on original qualitative data with families of donor conceived children, and bringing my data into conversation with social script theory and the concept of relationality, I investigate the disjuncture between the value now placed on openness and storytelling, and the absence of an existing social script by which to do so. I show the nuanced ways in which this absence plays out on relational playing-fields, within multidimensional, intergenerational relationships. I suggest that in order to understand sociologically the significance and process of reproductive storytelling, it is vital to keep both the role of social scripts, and embedded relationality, firmly in view.
    • Ten simple rules for teaching applied programming in an authentic and immersive online environment

      editor: Schwartz, Russell; Hooley, Frances; orcid: 0000-0003-1048-4558; Freeman, Peter J.; orcid: 0000-0002-5838-5404; Davies, Angela C.; orcid: 0000-0002-3365-7231; email: angela.davies@manchester.ac.uk (Public Library of Science, 2021-08-05)
    • Terahertz Characterization of Lead-Free Dielectrics for Different Applications

      Zhang, Man; Zhang, Hangfeng; Jiang, Qinghui; orcid: 0000-0001-7851-2653; Gao, Feng; orcid: 0000-0002-5075-4076; Chen, Riqing; Zhang, Dou; orcid: 0000-0001-8555-2784; Reece, Michael John; orcid: 0000-0002-2293-7123; Yang, Bin; Viola, Giuseppe; Yan, Haixue; orcid: 0000-0002-4563-1100 (American Chemical Society (ACS), 2021-11-02)
    • Terahertz Characterization of Lead-Free Dielectrics for Different Applications

      Zhang, Man; Zhang, Hangfeng; Jiang, Qinghui; orcid: 0000-0001-7851-2653; Gao, Feng; orcid: 0000-0002-5075-4076; Chen, Riqing; Zhang, Dou; orcid: 0000-0001-8555-2784; Reece, Michael John; orcid: 0000-0002-2293-7123; Yang, Bin; Viola, Giuseppe; Yan, Haixue; orcid: 0000-0002-4563-1100 (American Chemical Society (ACS), 2021-11-02)
    • Terahertz Characterization of Lead-Free Dielectrics for Different Applications

      Zhang, Man; Zhang, Hangfeng; Jiang, Qinghui; orcid: 0000-0001-7851-2653; Gao, Feng; orcid: 0000-0002-5075-4076; Chen, Riqing; Zhang, Dou; orcid: 0000-0001-8555-2784; Reece, Michael John; orcid: 0000-0002-2293-7123; Yang, Bin; Viola, Giuseppe; Yan, Haixue; orcid: 0000-0002-4563-1100 (American Chemical Society (ACS), 2021-11-02)
    • Terahertz Signatures of Hydrate Formation in Alkali Halide Solutions

      Chen, Ligang; Ren, Guanhua; Liu, Liyuan; orcid: 0000-0002-7050-3792; Guo, Pan; Wang, Endong; Zhou, Lu; Zhu, Zhongjie; Zhang, Jianbing; Yang, Bin; Zhang, Wentao; et al. (American Chemical Society (ACS), 2020-08-06)
    • Tessellation strategy for the interfacial synthesis of an anthracene-based 2D polymer

      Chen, Renzeng; Wang, Danbo; Hao, Wenbo; Shao, Feng; orcid: 0000-0003-3879-5884; email: feng.shao@manchester.ac.uk; Zhao, Yingjie; orcid: 0000-0002-2668-3722 (2021-05-17)
      Inspired by the tessellation or tiling process in daily life, a rigid triangular macrocyclic molecule containing anthracene as a photo-active moiety was synthesized to realize pre-organization through π-π interactions. The successful preparation of a 2D polymer monolayer at the air/water interface was achieved through [4+4]-photocycloaddition.
    • The blue hue of einsteinium.

      Natrajan, Louise S; orcid: 0000-0002-9451-3557; email: louise.natrajan@manchester.ac.uk; Faulkner, Stephen; email: stephen.faulkner@keble.ox.ac.uk (2021-05)
    • The cat is out of the bag – point-of-care testing (POCT) is here to stay

      Phin, Nick; Poutanen, Susan M (European Centre for Disease Control and Prevention (ECDC), 2020-11-05)
    • The challenge of hospitality: marking remembrance as an Anglican in a multifaith parish

      Lees-Smith, Anthony; orcid: 0000-0002-4322-3998 (Informa UK Limited, 2021-02-14)
    • The challenge of relational referents in early word extensions: Evidence from noun-noun compounds.

      Snape, Simon; Krott, Andrea (2021-02-15)
      Young children struggle more with mapping novel words onto relational referents (e.g., verbs) compared to non-relational referents (e.g., nouns). We present further evidence for this notion by investigating children's extensions of noun-noun compounds, which map onto combinations of non-relational referents, i.e., objects (e.g., baby and bottle for baby bottle), and relations (e.g., a bottle FOR babies). We tested two- to five-year-olds' and adults' generalisations of novel compounds composed of novel (e.g., kig donka) or familiar (e.g., star hat) nouns that were combined by one of two relations (e.g., donka that has a kig attached (=attachment relation) versus donka that stores a kig (=function relation)). Participants chose between a relational (shared relation) and a non-relational (same colour) match. Results showed a developmental shift from encoding non-relational aspects (colour) towards relations of compound referents, supporting the challenge of relational word referents. Also, attachment relations were more frequently encoded than function relations.
    • The Challenges of Measuring Informal Care Time: A Review of the Literature.

      Urwin, Sean; orcid: 0000-0002-9084-8368; email: sean.urwin@manchester.ac.uk; Lau, Yiu-Shing; Grande, Gunn; Sutton, Matt (2021-07-29)
      Economic evaluations increasingly include the value of informal care, for example, in terms of caregiver health effects or time costs. If an economic evaluation uses caregiving time costs, appropriate measurement of caregiving time is an important first step prior to its valuation. There is no comprehensive overview of the measurement challenges for caregiving time. In this literature review, we searched Medline, Embase, Econlit and Scopus to identify measurement issues and associated studies which reported informal care time that addressed them. The search identified 27 studies that addressed nine measurement issues. There is limited evidence on how to address these issues, although some have received relatively more attention, including incremental time (considered in 16 studies), time measurement method comparisons (six studies) and the inclusion of intangible tasks (four studies). Non-response (considered in only one study) and carer and recipient identification (two studies) were the most wide-reaching measurement concerns, as these determine who is identified as carers. There was no evidence on the consequences of these measurement challenges in terms of impacts on cost-effectiveness ratios and on the total cost of health conditions, which would be a crucial next step. Future research on these issues should consider a range of different settings, as informal care is highly heterogeneous. The measurement of informal care is key for its inclusion in economic evaluations but there is little consensus on how to appropriately measure this type of care. [Abstract copyright: © 2021. The Author(s).]
    • The city‐island‐state, wounding cascade and multi‐level vulnerability explored through the lens of Malta

      Main, Geoff; orcid: 0000-0001-8453-1527; Schembri, John; Speake, Janet; Gauci, Ritienne; Chester, David (Wiley, 2021-03-20)
    • The city‐island‐state, wounding cascade, and multi‐level vulnerability explored through the lens of Malta

      Main, Geoff; orcid: 0000-0001-8453-1527; Schembri, John; Speake, Janet; Gauci, Ritienne; Chester, David (Wiley, 2021-05-06)
    • The city‐island‐state, wounding cascade, and multi‐level vulnerability explored through the lens of Malta

      Main, Geoff; orcid: 0000-0001-8453-1527; Schembri, John; Speake, Janet; Gauci, Ritienne; Chester, David (Wiley, 2021-05-06)
    • The Comparative Effects of Mesenchymal Stem Cell Transplantation Therapy for Spinal Cord Injury in Humans and Animal Models: A Systematic Review and Meta-Analysis.

      Johnson, Louis D V; Pickard, Mark R; Johnson, William E B (2021-03-16)
      Animal models have been used in preclinical research to examine potential new treatments for spinal cord injury (SCI), including mesenchymal stem cell (MSC) transplantation. MSC transplants have been studied in early human trials. Whether the animal models represent the human studies is unclear. This systematic review and meta-analysis has examined the effects of MSC transplants in human and animal studies. Following searches of PubMed, Clinical Trials and the Cochrane Library, published papers were screened, and data were extracted and analysed. MSC transplantation was associated with significantly improved motor and sensory function in humans, and significantly increased locomotor function in animals. However, there are discrepancies between the studies of human participants and animal models, including timing of MSC transplant post-injury and source of MSCs. Additionally, difficulty in the comparison of functional outcome measures across species limits the predictive nature of the animal research. These findings have been summarised, and recommendations for further research are discussed to better enable the translation of animal models to MSC-based human clinical therapy.