• The relationship between target joints and direct resource use in severe haemophilia

      O’Hara, Jamie; Walsh, Shaun; Camp, Charlotte; Mazza, Giuseppe; Carroll, Liz; Hoxer, Christina; Wilkinson, Lars; University of Chester; HCD Economics, The Innovation Centre, Daresbury; University College London; The Haemophilia Society; Novo Nordisk A/S (SpringerOpen, 2018-01-16)
      Objectives Target joints are a common complication of severe haemophilia. While factor replacement therapy constitutes the majority of costs in haemophilia, the relationship between target joints and non drug-related direct costs (NDDCs) has not been studied. Methods Data on haemophilia patients without inhibitors was drawn from the ‘Cost of Haemophilia across Europe – a Socioeconomic Survey’ (CHESS) study, a cost assessment in severe haemophilia A and B across five European countries (France, Germany, Italy, Spain, and the United Kingdom) in which 139 haemophilia specialists provided demographic and clinical information for 1285 adult patients. NDDCs were calculated using publicly available cost data, including 12-month ambulatory and secondary care activity: haematologist and other specialist consultant consultations, medical tests and examinations, bleed-related hospital admissions, and payments to professional care providers. A generalized linear model was developed to investigate the relationship between NDDCs and target joints (areas of chronic synovitis), adjusted for patient covariates. Results Five hundred and thirteen patients (42% of the sample) had no diagnosed target joints; a total of 1376 target joints (range 1–10) were recorded in the remaining 714 patients. Mean adjusted NDDCs for persons with no target joints were EUR 3134 (standard error (SE) EUR 158); for persons with one or more target joints, mean adjusted NDDCs were EUR 3913 (SE EUR 157; average mean effect EUR 779; p < 0.001). Conclusions Our analysis suggests that the presence of one or more target joints has a significant impact on NDDCs for patients with severe haemophilia, ceteris paribus. Prevention and management of target joints should be an important consideration of managing haemophilia patients.
    • The ReSiT study (reducing sitting time): rationale and protocol for an exploratory pilot study of an intervention to reduce sitting time among office workers

      Gardner, Benjamin; Dewitt, Stephen; Smith, Lee; Buckley, John P.; Biddle, Stuart J. H.; Mansfield, Louise; King's College London; Anglia Ruskin University; University of Chester; University of Southern Queensland; Brunel University (BioMed Central, 2017-11-28)
      Background Desk-based workers engage in long periods of uninterrupted sitting time, which has been associated with morbidity and premature mortality. Previous workplace intervention trials have demonstrated the potential of providing sit-stand workstations, and of administering motivational behaviour change techniques, for reducing sitting time. Yet, few studies have combined these approaches or explored the acceptability of discrete sitting-reduction behaviour change strategies. This paper describes the rationale for a sitting-reduction intervention that combines sit-stand workstations with motivational techniques, and procedures for a pilot study to explore the acceptability of core intervention components among university office workers. Methods The intervention is based on a theory and evidence-based analysis of why office workers sit, and how best to reduce sitting time. It seeks to enhance motivation and capability, as well as identify opportunities, required to reduce sitting time. Thirty office workers will participate in the pilot study. They will complete an initial awareness-raising monitoring and feedback task and subsequently receive a sit-stand workstation for a 12-week period. They will also select from a ‘menu’ of behaviour change techniques tailored to self-declared barriers to sitting reduction, effectively co-producing and personally tailoring their intervention. Interviews at 1, 6, and 12 weeks post-intervention will explore intervention acceptability. Discussion To our knowledge, this will be the first study to explore direct feedback from office workers on the acceptability of discrete tailored sitting-reduction intervention components that they have received. Participants’ choice of and reflections on intervention techniques will aid identification of strategies suitable for inclusion in the next iteration of the intervention, which will be delivered in a self-administered format to minimise resource burden. Trial registration ISRCTN29395780 (registered 21 November 2016)
    • Selling the news: Distributing Wrexham's newspapers, 1850-1914

      Peters, Lisa; Skinner, Katherine; University of Chester (Oak Knoll Press & The British Library, 2009-07)
      This book chapter discusses how Wrexham's newspapers developed a reliable distribution service through north and mid Wales and parts of Cheshire and Shropshire. The role of agents and how their location reflected a newspaper's circulation area is particuarly discussed.
    • Still Wrexham's longest running newspaper - the Wrexham Advertiser

      Peters, Lisa; University of Chester (Bridge Books, 2012-03)
      This article discuss the Wrexham Advertiser - a newspaper which ran from 1850 to 1957.
    • Structural characterisation of two pharmaceutically important steroids by solid-state NMR

      Othman, Abdullah; Harris, Robin K.; Hodgkinson, Paul; Christopher, Elizabeth A.; Lancaster, Robert W.; University of Durham ; University of Durham ; University of Durham ; University of Chester/University of Durham ; University of Durham (Royal Society of Chemistry/Centre National de la Recherche Scientifique, 2008)
      Several crystal modifications of two steroids (androsterone and beclomethasone dipropionate) have been characterised by solid-state NMR methods, and the chemical shifts between the different forms compared. The gradual loss of water from androsterone hemihydrate has been monitored by XRPD. The crystal structures are discussed in relation to the NMR data. That of the beclomethasone dipropionate ethyl acetate solvate has been determined for the first time. It is found that there are clear channels containing the ethyl acetate molecules, which are apparently not incorporated by hydrogen bonding. Carbon-13 CPMAS spectra with long contact times and MAS proton spectra are used to show the mobility of ethyl acetate molecules in the BDP solvate. The second-order effect of chlorine on the 13C spectrum of beclomethasone dipropionate monohydrate has been explored by varying the applied magnetic field.
    • The student enrichment programme: An inter-professional collaboration

      Greenwood, Joanne M.; Thomas, Helen; Sinnott, Celia; Headon, Stephanie; Rogers, Lisa; University of Chester (2011-06-15)
      This presentation discusses how Learning Support Unit, Learning Information Services, Careers and Employability work together with academic lecturers to deliver skills sessions to nursing students.
    • Taking the pain out of network induction: Using INFORMS to induct new first year students

      Fiander, Wendy; Peters, Lisa; Sinclair, Colin (SCONUL, 2003)
      In September 2003, Learning Resources at University College Chester used the JISC-funded INFORMS tutorial for student induction into the computer network. The article comments on how the INFORMS computer induction tutorial was developed at Chester, how it was used, and plans for future developments.
    • Tamaglitchi

      Collins, Karen; Dockwray, Ruth (ACM Press, 2018)
    • TEST delete 11-3-19

      Moore, Gavin R.; Moore, Gavin R. (12/07/2019)
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    • THE HEALTH IMPACT OF SCAMS

      Bailey, Jan; Kingston, Paul; Taylor, Louise; Eost-Telling, Louise (Oxford University Press (OUP), 2019-11-08)
      Abstract This presentation will offer new and alternate insights into ‘scams’ and the health effects of fraud on older people. It reports data captured from a Mass Observation Project “Directive” focusing on scams and their impact on individuals. Eighty “Observers’” aged 50 and over responded to the “Directive”. Responses indicate that falling victim to a scam may have negative impacts on individuals’ mental wellbeing, self-esteem and relationships with others. Data analysis also identified that fear of victimisation can also affect individuals, resulting in worry, anxiety and maladaptive coping strategies. Offering a sociology of health perspective, we will focus is on these health impacts of scams and the legitimisation of the issue as a socio-political problem. We will also highlight additional important areas for consideration, such as the absence of a common understanding of the concept and nomenclature of ‘scam’, and the ‘vagaries of scams’ by presenting a typology of scams.
    • THE METHODOLOGICAL RELEVANCE OF MASS OBSERVATION DATA

      Eost-Telling, Charlotte L; Kingston, Paul; Taylor, Louise; Bailey, Jan (Oxford University Press (OUP), 2019-11-08)
      Abstract The Mass Observation Project, established in 1937, documents the lives of ordinary people living in the UK, and explores a wide range of social issues. The Project distributes a set of written questions (“Directives”) to a panel of 500 members of the British public (“Observers”) three times each year; “Observers” respond in writing. From the initial commissioning of a “Directive” to data becoming available for analysis takes between four to six months. This approach offers researchers an opportunity to capture in-depth qualitative data from individuals with a range of demographic backgrounds who live across the UK. As there are no word limits on “Observers’” responses and they remain anonymous, a “Directive” often yields rich, high-quality data. Additionally, compared with alternative methods of collecting large volumes of qualitative data from a heterogeneous population, commissioning a “Directive” is cost-effective in terms of time and resource.
    • Trabant: Go with the legend

      Lowe, Austen; Stone, Mark (Drystone Radio, 2018-11-18)
      "The car is that mediation between state and society. If you look at when they finally opened the borders for people to go West, the Trabis also went with them." Modern Languages undergraduate Austen Lowe was invited to Drystone Radio's Backseat Driver show to discuss his research on the Trabant with Mark Stone. This radio broadcast outlines the misunderstandings surrounding GDR mobility. The conversation focusses on how the wooden and plastic car personifies the state in which it was made. The broadcast aims to draw parallels between production techniques in the GDR and the FRG, relating these methods to cars produced more recently in Zwickau. What did quality actually mean in the GDR and is the Trabant really a motoring legend?
    • Transposing tirtha: Understanding religious reforms and locative piety in early modern Hinduism

      Thakkar, Chirayu; University of Chester (SpringerOpen, 2017-06-17)
      The paper deals with a historical and hitherto obscure case of de-commercialisation of sacred geography of India. Sahajanand Swami, an eighteenth century religious leader from Gujarat who became popular as Bhagwan Swaminarayan took an initiative to eliminate corruption in Dwarka, one of the most sacred destination in Hindu imagination. He also attempted to transpose the piety of Dwarka and recreate a parallel religious experience at Vadtal, an important site in Swaminarayan Hinduism. This process of making sacred sites more egalitarian is classified here as a 'religious reform'. The paper assesses this bivalent pursuit as an institutional reform within religion as well as a religious process in the context of piety, authority and orthodoxy. Through the example of Sahajanand Swami, it is argued to calibrate the colonial paradigm of reform that was largely contextual to social issues and western thought and failed to appreciate the religious reforms of that era. By constructing a nuanced typology of 'religious reform' distinct from 'social reforms', the paper eventually calls for a reassessment of religious figures who have significantly contributed in reforming the Hindu tradition in the medieval and modern era.
    • Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

      Hulme, Charlotte H.; Wilson, Emma L.; Fuller, Heidi R.; Roberts, Sally; Richardson, James B.; Gallacher, Pete; Peffers, Mandy J.; Shirran, Sally L.; Botting, Catherine H.; Wright, Karina T.; et al. (BioMed Central, 02/05/2018)
      Background: Autologous chondrocyte implantation (ACI) has a failure rate of approximately 20%, but it is yet to be fully understood why. Biomarkers are needed that can pre-operatively predict in which patients it is likely to fail, so that alternative or individualised therapies can be offered. We previously used label-free quantitation (LF) with a dynamic range compression proteomic approach to assess the synovial fluid (SF) of ACI responders and non-responders. However, we were able to identify only a few differentially abundant proteins at baseline. In the present study, we built upon these previous findings by assessing higher-abundance proteins within this SF, providing a more global proteomic analysis on the basis of which more of the biology underlying ACI success or failure can be understood. Methods: Isobaric tagging for relative and absolute quantitation (iTRAQ) proteomic analysis was used to assess SF from ACI responders (mean Lysholm improvement of 33; n = 14) and non-responders (mean Lysholm decrease of 14; n = 13) at the two stages of surgery (cartilage harvest and chondrocyte implantation). Differentially abundant proteins in iTRAQ and combined iTRAQ and LF datasets were investigated using pathway and network analyses. Results: iTRAQ proteomic analysis confirmed our previous finding that there is a marked proteomic shift in response to cartilage harvest (70 and 54 proteins demonstrating ≥ 2.0-fold change and p < 0.05 between stages I and II in responders and non-responders, respectively). Further, it highlighted 28 proteins that were differentially abundant between responders and non-responders to ACI, which were not found in the LF study, 16 of which were altered at baseline. The differential expression of two proteins (complement C1s subcomponent and matrix metalloproteinase 3) was confirmed biochemically. Combination of the iTRAQ and LF proteomic datasets generated in-depth SF proteome information that was used to generate interactome networks representing ACI success or failure. Functional pathways that are dysregulated in ACI non-responders were identified, including acute-phase response signalling. Conclusions: Several candidate biomarkers for baseline prediction of ACI outcome were identified. A holistic overview of the SF proteome in responders and non-responders to ACI  has been profiled, providing a better understanding of the biological pathways underlying clinical outcome, particularly the differential response to cartilage harvest in non-responders.
    • University College Chester: the impact of investment in electronic resources

      Fiander, Wendy; Peters, Lisa (Library and Information Research Group, 2005)
      This article discusses the impact of electronic information services on teaching and learning, the production of "impact indicators" to evaludate the usefulness of electronic resources, and how to increase the percieved value of electronic resources in the academic community.
    • Using the CLA scanning licence to offer 24x7 access to in-demand book chapters and journal articles at the University of Chester

      Peters, Lisa; University of Chester (SCONUL, 2009-12)
      This article discusses the implementation and operation of the CLA scanning licence at the University of Chester library.
    • A voting system to enhance interactivity for students

      Fiander, Wendy; Evans, David (2007-06-01)
      This presentation discusses optivote - a radio-frequency voting system which can increase interactivity in a session - it works the same way as the 'ask the audience' feature of 'Who wants to be a millionaire'. Each set consists of 32 voting handsets, a laptop loaded with the necessary software, a radio receiver and instructions. The system will work with powerpoint slides to provide a range of question types as part of a presentation. It can give immediate feedback to students on their answers and the lecturer can obtain reports about the individual responses of their students.
    • "Welsh obscurity to notoriety" - Lloyd George, the Boer War, and the North Wales Press

      Peters, Lisa; University of Chester (Oak Knoll Press & The British Library, 2008-05)
      This book chapter discusses the actions of David Lloyd George (MP for the Carnarvon Boroughs and future Prime Minister) during the Boer War of 1899-1902 as seen by the local North Wales press, The chapter seeks to cast light upon local views of Lloyd George's stance and explain why he was re-elected with an increased majority in the 1900 general election, despite accusations of treason. Newspapers analysed include the Carnarvon & Denbigh Herald, the North Wales Times, Yr Herald Cymraeg, the North Wales Chronicle, the Wrexham Advertiser, the North Wales Guardian, the Holyhead Mail and Anglesey Herald, and Y Baner ac Amserau Cymru.
    • Welsh periodicals in the nineteenth century

      Peters, Lisa; University of Chester (2014-05-27)
      This presentation places the developing Welsh periodical press within the changing economic, political, and social nature of nineteenth century Wales.