• What’s in a name? Family violence involving older adults

      Benbow, Susan M.; Bhattacharyya, Sharmi; Kingston, Paul (Emerald, 2018-12-10)
    • Human adipose tissue-derived mesenchymal stem/stromal cells adhere to and inhibit the growth of Staphylococcus aureus and Pseudomonas aeruginosa

      Wood, Chelsea Rheannon; Al Dhahri, Douaa; Al Delfi, Ibtesam; Pickles, Neil Anthony; Sammons, Rachel L.; Worthington, Tony; Wright, Karina Theresa; Johnson, William Eustace Basil (Microbiology Society, 2018-12-01)
    • Experimental Sound Mixing for The Well, a Short Film Made for Tablets

      Collins, Karen; Dockwray, Ruth (MIT Press - Journals, 2018-12)
    • Stent Frame Movement Following Endovascular Aneurysm Sealing in the Abdominal Aorta

      Yafawi, Asma; orcid: 0000-0002-8390-9951; McWilliams, Richard G.; Fisher, Robert K.; England, Andrew; Karouki, Maria; Torella, Francesco (SAGE Publications, 2018-11-28)
    • Body Part Removal: A Thematic Exploration of U.K. Homicide Offenses

      Almond, Louise; Pell, Connor; McManus, Michelle (SAGE Publications, 2018-11-28)
    • Enhancement in Interfacial Adhesion of Ti/Polyetheretherketone by Electrophoretic Deposition of Graphene Oxide

      Pan, Lei; Lv, Yunfei; orcid: 0000-0001-9342-0116; Nipon, Roy; Wang, Yifan; orcid: 0000-0003-2351-3223; Duan, Lixiang; Hu, Jingling; Ding, Wenye; Ma, Wenliang; Tao, Jie; Shi, Yu (Wiley, 2018-11-25)
    • Enhancing outcomes and reducing inhibitors to the engagement of students and staff in learning and teaching partnerships: implications for academic development

      Matthews, Kelly E.; orcid: 0000-0002-6563-4405; Mercer-Mapstone, Lucy; orcid: 0000-0001-7441-6568; Dvorakova, Sam Lucie; Acai, Anita; orcid: 0000-0002-9901-2946; Cook-Sather, Alison; orcid: 0000-0002-0116-7158; Felten, Peter; orcid: 0000-0003-0739-7680; Healey, Mick; orcid: 0000-0003-1195-0370; Healey, Ruth L.; orcid: 0000-0001-6872-4900; Marquis, Elizabeth; orcid: 0000-0002-7362-678X (Informa UK Limited, 2018-11-20)
    • Exploring Preceptorship Programmes: Implications for Future Design.

      Taylor, Louise M; Eost-Telling, Charlotte L; orcid: 0000-0002-9568-3195; Ellerton, Annie (2018-11-15)
      To review and analyse current preceptorship programmes within NHS trusts in the North West of England. To evaluate the pedagogic rigour of the programme and suggest recommendations to inform the future design of preceptorship programmes. Enhancing the retention of newly qualified staff is of particular importance given that the journey from a new registrant to a competent healthcare professional poses a number of challenges, for both the individual staff member and organisations. A mixed methods evaluative approach was employed, using online questionnaires and content analysis of preceptorship documentation. Forty-one NHS trusts across the North West region employing newly qualified nurses were invited to participate in the completion of an online questionnaire. In addition, preceptorship programme documentation was requested for inclusion in the content analysis. This study utilised the SQUIRE (Standards for Quality Improvement Reporting Excellence) guidelines. The response rate for the questionnaire was 56.1% (n=23). Eighteen trusts (43.9%) forwarded their programme documentation. Findings highlighted the wide variation in preceptorship programmes across the geographical footprint. There were instances of outstanding preceptorship and preceptorship programmes where there was a clear link between the strategic vision, i.e., trust policy, and its delivery, i.e. preceptorship offering. There was no one framework that would universally meet the needs of all trusts, yet there are key components which should be included in all preceptorship programmes. Therefore, we would encourage innovation and creativity in preceptorship programmes, cognisant of local context. The significant shortage of nursing staff in England is an ongoing issue. Recruitment and retention are key to ameliorating the shortfall, and formal support mechanisms like preceptorship, can improve the retention of newly qualified staff. Understanding current preceptorship programmes is an important first step in establishing the fundamental building blocks of successful preceptorship programmes and enabling the sharing of exemplary good practice across organisations. This article is protected by copyright. All rights reserved. [Abstract copyright: This article is protected by copyright. All rights reserved.]
    • Exploring Preceptorship Programmes: Implications for Future Design

      Taylor, Louise M; Eost-Telling, Charlotte L; orcid: 0000-0002-9568-3195; Ellerton, Annie (Wiley, 2018-11-15)
    • Mathematical models of DNA methylation dynamics: Implications for health and ageing.

      Zagkos, Loukas; email: z.loukas@chester.ac.uk; Auley, Mark Mc; email: m.mcauley@chester.ac.uk; Roberts, Jason; email: j.roberts@chester.ac.uk; Kavallaris, Nikos I; email: n.kavallaris@chester.ac.uk (2018-11-15)
      DNA methylation is a key epigenetic process which has been intimately associated with gene regulation. In recent years growing evidence has associated DNA methylation status with a variety of diseases including cancer, Alzheimer's disease and cardiovascular disease. Moreover, changes to DNA methylation have also recently been implicated in the ageing process. The factors which underpin DNA methylation are complex, and remain to be fully elucidated. Over the years mathematical modelling has helped to shed light on the dynamics of this important molecular system. Although the existing models have contributed significantly to our overall understanding of DNA methylation, they fall short of fully capturing the dynamics of this process. In this paper we develop a linear and nonlinear model which captures more fully the dynamics of the key intracellular events which characterise DNA methylation. In particular the outcomes of our linear model result in gene promoter specific methylation levels which are more biologically plausible than those revealed by previous mathematical models. In addition, our nonlinear model predicts DNA methylation promoter bistability which is commonly observed experimentally. The findings from our models have implications for our current understanding of how changes to the dynamics which underpin DNA methylation affect ageing and health. We also propose how our ideas can be tested in the lab. [Abstract copyright: Copyright © 2018 Elsevier Ltd. All rights reserved.]
    • Conscientious objection and physician-assisted suicide: a viable option in the UK?

      Willis, Derek; email: derekwillis35@hotmail.com; George, Rob (2018-11-15)
      Conscience objection is a proposed way of ensuring that medical practitioners who object to physician-assisted suicide may avoid having to be involved in such a procedure if this is legalised. This right on the part of healthcare professionals already exists in certain circumstances. This paper examines the ethical and legal grounds for conscientious objection for medical professionals and shows how it is heavily criticised in circumstances where it is already used. The paper comes to the conclusion that as the grounds and application of conscience objection are no longer as widely accepted, its future application in any legislation can be called into question. [Abstract copyright: © Author(s) (or their employer(s)) 2018. No commercial re-use. See rights and permissions. Published by BMJ.]
    • No Effect of Beetroot Juice Supplementation on 100-m and 200-m Swimming Performance in Moderately-Trained Swimmers.

      Esen, Ozcan; Nicholas, Ceri; Morris, Mike; Bailey, Stephen J (2018-11-14)
      Dietary nitrate supplementation has been reported to improve performance in kayaking and rowing exercise which mandate significant recruitment of the upper body musculature. Since the effect of dietary nitrate supplementation on swimming performance is unclear, the purpose of this study was to assess the effect of dietary nitrate supplementation on 100-m and 200-m swimming freestyle time-trial (TT) performance. In a double blind, randomized crossover design, ten moderately-trained swimmers underwent two separate 3-day supplementation periods, with a daily dose of either 140 mL nitrate-rich (BRJ; ~800 mg/d nitrate) or nitrate-depleted (PLA) BRJ. Following blood sampling on day 3, the swimmers performed both 200-m and 100-m freestyle swimming TTs, with 30 min recovery between trials. Plasma nitrite concentrations was greater after BRJ relative to PLA consumption (432 ± 203 nmol/L, 111 ± 56 nmol/L, respectively, p = 0.001). Systolic BP was lowered after BRJ compared to PLA supplementation (114 ± 10, 120 ± 10 mmHg, respectively p = 0.001), but time to complete the 200-m (BRJ: 152.6 ± 14.1 s, PLA: 152.5 ± 14.1 s) and 100-m (BRJ: 69.5 ± 7.2 s, PLA: 69.4 ± 7.4 s) freestyle swimming TTs were not different between BRJ and PLA (p > 0.05). While 3 days of BRJ supplementation increased plasma nitrite concentration and lowered blood pressure, it did not improve 100-m and 200-m swimming TT performance. These results do not support an ergogenic effect of nitrate supplementation in moderately-trained swimmers, at least for 100-m and 200-m freestyle swimming performance.
    • No Effect of Beetroot Juice Supplementation on 100-m and 200-m Swimming Performance in Moderately-Trained Swimmers

      Esen, Ozcan; Nicholas, Ceri; Morris, Mike; Bailey, Stephen J. (Human Kinetics, 2018-11-14)
    • Flood risk to commercial property

      Bhattacharya-Mis, Namrata; Lamond, Jessica; Montz, Burrell; Kreibich, Heidi; Wilkinson, Sara; Chan, Faith; Proverbs, David (Emerald, 2018-11-12)
    • Stern, gwiazda or star: Screening receptive vocabulary skills across languages in monolingual and bilingual German–Polish or German–Turkish children using a tablet application

      Schaefer, Blanca; Ehlert, Hanna; Kemp, Lisa; Hoesl, Kristina; Schrader, Verena; Warnecke, Clarissa; Herrmann, Frank (SAGE Publications, 2018-11-09)