• Copper-catalyzed functionalization of enynes.

      Dherbassy, Quentin; Manna, Srimanta; orcid: 0000-0002-3903-1256; Talbot, Fabien J T; Prasitwatcharakorn, Watcharapon; Perry, Gregory J P; orcid: 0000-0001-8173-3369; Procter, David J; orcid: 0000-0003-3179-2509 (2020-10-07)
      The copper-catalyzed functionalization of enyne derivatives has recently emerged as a powerful approach in contemporary synthesis. Enynes are versatile and readily accessible substrates that can undergo a variety of reactions to yield densely functionalized, enantioenriched products. In this perspective, we review copper-catalyzed transformations of enynes, such as boro- and hydrofunctionalizations, copper-mediated radical difunctionalizations, and cyclizations. Particular attention is given to the regiodivergent functionalization of 1,3-enynes, and the current mechanistic understanding of such processes. [Abstract copyright: This journal is © The Royal Society of Chemistry.]
    • Copper-catalyzed functionalization of enynes.

      Dherbassy, Quentin; Manna, Srimanta; orcid: 0000-0002-3903-1256; Talbot, Fabien J T; Prasitwatcharakorn, Watcharapon; Perry, Gregory J P; orcid: 0000-0001-8173-3369; Procter, David J; orcid: 0000-0003-3179-2509 (2020-10-07)
      The copper-catalyzed functionalization of enyne derivatives has recently emerged as a powerful approach in contemporary synthesis. Enynes are versatile and readily accessible substrates that can undergo a variety of reactions to yield densely functionalized, enantioenriched products. In this perspective, we review copper-catalyzed transformations of enynes, such as boro- and hydrofunctionalizations, copper-mediated radical difunctionalizations, and cyclizations. Particular attention is given to the regiodivergent functionalization of 1,3-enynes, and the current mechanistic understanding of such processes.