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dc.contributor.authorKanakis, Ioannis
dc.contributor.authorMyrtziou, Ioanna
dc.contributor.authorGoljanek-Whysall, Katarzyna
dc.contributor.authorVasilaki, Aphrodite
dc.date.accessioned2022-09-05T12:35:22Z
dc.date.available2022-09-05T12:35:22Z
dc.date.issued2021-11-23
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627149/nic0597ch04_au.pdf?sequence=1
dc.identifier.citationKanakis, I., Mirtziou, K., Vasilaki, A., & Goljanek-Whysall, K. (2022). MicroRNAs as central regulators of adult myogenesis and proteostasis loss in skeletal muscle ageing. In N. Chondrogianni, E. Pick, & A. Gioran (Eds.), Proteostasis and proteolysis. CRC Press.en_US
dc.identifier.isbn9781003048138en_US
dc.identifier.urihttp://hdl.handle.net/10034/627149
dc.descriptionThis is an Accepted Manuscript of a book chapter published by CRC Press in [Proteostasis and proteolysis] on [5/11/2021], available online: http://www.crcpress.com/9780367499327en_US
dc.description.abstractSarcopenia (from the Greek words sarca (σάρκα) = flesh and penia (πενία) = deficiency) is considered as an age-associated disease, characterized by dysregulation of the balance between muscle hypertrophy, atrophy and regeneration, which leads to advanced loss of skeletal muscle mass and function associated with a high risk of falls and fractures in the elderly. Numerous studies in humans and animals have explored the pathophysiology of musculoskeletal aging but the detailed mechanisms that contribute to skeletal muscle dysfunction have not been yet fully elucidated. Recently, several studies have focused on the role of microRNAs as a dynamic and promising epigenetic mechanism which may regulate post-transcriptional gene expression that modulate skeletal muscle homeostasis. In this chapter, we describe the crucial role of microRNAs in skeletal myogenesis during adulthood and their association with the pathogenesis of sarcopenia linked to proteostasis loss.en_US
dc.publisherCRC Pressen_US
dc.relation.urlhttps://www.routledge.com/Proteostasis-and-Proteolysis/Chondrogianni-Pick-Gioran/p/book/9780367499327en_US
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectmicroRNAsen_US
dc.subjectAgeingen_US
dc.subjectMusculoskeletalen_US
dc.titleMicroRNAs as central regulators of adult myogenesis and proteostasis loss in skeletal muscle ageingen_US
dc.typeBook chapteren_US
dc.contributor.departmentUniversity of Liverpool; University of Chester; NUI Galwayen_US
or.grant.openaccessYesen_US
rioxxterms.funderBBSRCen_US
rioxxterms.identifier.projectBB/P008429/1en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.startdate2022-11-23
dcterms.dateAccepted2021
rioxxterms.publicationdate2021-11-23
dc.date.deposited2022-09-05en_US


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