Show simple item record

dc.contributor.authorMc Auley, Mark T.
dc.contributor.authorMorgan, Amy
dc.date.accessioned2022-09-02T13:06:16Z
dc.date.available2022-09-02T13:06:16Z
dc.date.issued2022-04-26
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627137/Cholesterol%20chapter.pdf?sequence=3
dc.identifier.citationMc Auley, M. T. & Morgan, A. (2022). Cholesterol transport in blood, lipoproteins, and cholesterol metabolism. In A. Bukiya & A. Dopico (Eds.), Cholesterol: From chemistry and biophysics to the clinic (pp. 227-258). Elsevier.en_US
dc.identifier.isbn9780323858571en_US
dc.identifier.urihttp://hdl.handle.net/10034/627137
dc.description.abstractThe aim of this chapter is to critically discuss recent work which has focused on the dynamics of cholesterol transport and its intersection with health. Firstly, we provide an overview of the main lipoproteins, and their role in whole-body cholesterol metabolism. We then focus on low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C), paying particular attention to a diverse array of evidence which associates perturbations to these lipoproteins with cardiovascular disease (CVD). Next, we explain how aging and obesity disrupt the biological mechanisms that regulate cholesterol metabolism. Crucially, we reveal the parallels between aging and obesity, underscoring that obesity superimposed on the aging process has the potential to exacerbate the age-related dysregulation of cholesterol metabolism. Following this, we unveil how mathematical modeling can be used to deepen our understanding of cholesterol metabolism. We conclude the chapter by discussing the future of this area; in doing so, we reveal how recent experimental findings could open the way for novel therapeutic approaches which could help maintain optimal blood lipoprotein levels and thus increase health span.en_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.elsevier.com/books/cholesterol/bukiya/978-0-323-85857-1en_US
dc.relation.urlhttps://www.sciencedirect.com/book/9780323858571/cholesterolen_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectLow-density lipoprotein cholesterolen_US
dc.subjectHigh-density lipoprotein cholesterolen_US
dc.subjectAtherosclerosisen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectAgingen_US
dc.subjectObesityen_US
dc.titleCholesterol transport in blood, lipoproteins, and cholesterol metabolism.en_US
dc.typeBook chapteren_US
dc.contributor.departmentUniversity of Chesteren_US
or.grant.openaccessYesen_US
rioxxterms.funderunfundeden_US
rioxxterms.identifier.projectunfundeden_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.startdate2222-04-26
dcterms.dateAccepted2021-08-01
rioxxterms.publicationdate2022-04-26
dc.date.deposited2022-09-02en_US


Files in this item

Thumbnail
Name:
Cholesterol chapter.pdf
Embargo:
2222-04-26
Size:
431.6Kb
Format:
PDF
Request:
Book Chapter

This item appears in the following Collection(s)

Show simple item record

https://creativecommons.org/licenses/by-nc-nd/4.0/
Except where otherwise noted, this item's license is described as https://creativecommons.org/licenses/by-nc-nd/4.0/