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dc.contributor.authorWarren, Tara
dc.contributor.authorMcAliister, Roisin
dc.contributor.authorMorgan, Amy
dc.contributor.authorSingh Rai, Taranjit
dc.contributor.authorMcGilligan, Victoria
dc.contributor.authorEnnis, Matthew
dc.contributor.authorPage, Christopher
dc.contributor.authorKelly, Catriona
dc.contributor.authorPeace, Aaron
dc.contributor.authorCorfe, Bernard M.
dc.contributor.authorMc Auley, Mark T.
dc.contributor.authorWatterson, Steven
dc.date.accessioned2022-08-30T13:17:02Z
dc.date.available2022-08-30T13:17:02Z
dc.date.issued2021-08-06
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627129/cells-10-02007-v2.pdf?sequence=5
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627129/Warren%20et%20al%202021.pdf?sequence=4
dc.identifier.citationWarren, T., McAllister, R., Morgan, A., Rai, T. S., McGilligan, V., Ennis, M., Page, C., Kelly, C., Peace, A., Corfe, B. M., Mc Auley, M., & Watterson, S. (2021). The interdependency and co-regulation of the Vitamin D and cholesterol metabolism. Cells, 10(8), 2007. https://doi.org/10.3390/cells10082007en_US
dc.identifier.issnNo print ISSN
dc.identifier.doi10.3390/cells10082007
dc.identifier.urihttp://hdl.handle.net/10034/627129
dc.description.abstractVitamin D and cholesterol metabolism overlap significantly in the pathways that contribute to their biosynthesis. However, our understanding of their independent and co-regulation is limited. Cardiovascular disease is the leading cause of death globally and atherosclerosis, the pathology associated with elevated cholesterol, is the leading cause of cardiovascular disease. It is therefore important to understand vitamin D metabolism as a contributory factor. From the literature, we compile evidence of how these systems interact, relating the understanding of the molecular mechanisms involved to the results from observational studies. We also present the first systems biology pathway map of the joint cholesterol and vitamin D metabolisms made available using the Systems Biology Graphical Notation (SBGN) Markup Language (SBGNML). It is shown that the relationship between vitamin D supplementation, total cholesterol, and LDL-C status, and between latitude, vitamin D, and cholesterol status are consistent with our knowledge of molecular mechanisms. We also highlight the results that cannot be explained with our current knowledge of molecular mechanisms: (i) vitamin D supplementation mitigates the side-effects of statin therapy; (ii) statin therapy does not impact upon vitamin D status; and critically (iii) vitamin D supplementation does not improve cardiovascular outcomes, despite improving cardiovascular risk factors. For (iii), we present a hypothesis, based on observations in the literature, that describes how vitamin D regulates the balance between cellular and plasma cholesterol. Answering these questions will create significant opportunities for advancement in our understanding of cardiovascular healthen_US
dc.publisherMDPIen_US
dc.relation.urlhttps://www.mdpi.com/2073-4409/10/8/2007en_US
dc.rightsCC0 1.0 Universal*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/en_US
dc.subjectCholesterolen_US
dc.subjectVitamin Den_US
dc.subjectSystems biologyen_US
dc.subjectRegulationen_US
dc.subjectPathway biologyen_US
dc.titleThe interdependency and co-regulation of the vitamin D and cholesterol metabolism.en_US
dc.typeArticleen_US
dc.identifier.eissn2073-4409en_US
dc.contributor.departmentUlster University; University of Chester; Altnagelvin Regional Hospital, Derry; Newcastle Universityen_US
dc.identifier.journalCellsen_US
or.grant.openaccessYesen_US
rioxxterms.funderunfundeden_US
rioxxterms.identifier.projectunfundeden_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecord10.3390/cells10082007en_US
dcterms.dateAccepted2021-07-28
rioxxterms.publicationdate2021-08-06
dc.date.deposited2022-08-30en_US
dc.indentifier.issnNo print ISSNen_US


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CC0 1.0 Universal
Except where otherwise noted, this item's license is described as CC0 1.0 Universal