Show simple item record

dc.contributor.authorLausecker, Franziska
dc.contributor.authorLennon, Rachel
dc.contributor.authorRandles, Michael J
dc.date.accessioned2022-08-06T01:03:53Z
dc.date.available2022-08-06T01:03:53Z
dc.date.issued2022-07-20
dc.date.submitted2022-01-21
dc.identifierpubmed: 35870643
dc.identifierpii: S0085-2538(22)00544-0
dc.identifierdoi: 10.1016/j.kint.2022.06.029
dc.identifier.citationKidney international, article-number S0085-2538(22)00544-0
dc.identifier.urihttp://hdl.handle.net/10034/627068
dc.descriptionFrom PubMed via Jisc Publications Router
dc.descriptionHistory: received 2022-01-21, revised 2022-06-15, accepted 2022-06-24
dc.descriptionPublication status: aheadofprint
dc.description.abstractDysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope of developing therapies to combat matrix dysregulation, requires the integration of data acquired by both well-established and novel technologies. Owing to its complexity, the extracellular proteome, or matrisome, still holds many secrets and has great potential for the identification of clinical biomarkers and drug targets. The molecular resolution of matrix composition during aging and disease has been illuminated by cutting-edge mass spectrometry-based proteomics in recent years, but there remain key questions about the mechanisms that drive altered matrix composition. Basement membrane components are particularly important in the context of kidney function; and data from proteomic studies suggest that switches between basement membrane and interstitial matrix proteins are likely to contribute to organ dysfunction during aging and disease. Understanding the impact of such changes on physical properties of the matrix, and the subsequent cellular response to altered stiffness and viscoelasticity, is of critical importance. Likewise, the comparison of proteomic datasets from multiple organs is required to identify common matrix biomarkers and shared pathways for therapeutic intervention. Coupled with single cell transcriptomics there is the potential to identify the cellular origin of matrix changes, which could enable cell targeted therapy. This review provides a contemporary perspective of the complex kidney matrisome and draws comparison to altered matrix in heart and liver disease. [Abstract copyright: Copyright © 2022. Published by Elsevier Inc.]
dc.languageeng
dc.sourceeissn: 1523-1755
dc.subjecttubulointerstitium
dc.subjectglomerulus
dc.subjectbasement membrane
dc.subjectscRNAseq
dc.subjectmass spectrometry
dc.subjectmatrix signature
dc.subjectfibrosis
dc.subjectExtracellular matrix
dc.subjectproteomics
dc.titleThe kidney matrisome in health, aging and disease.
dc.typearticle
dc.date.updated2022-08-06T01:03:53Z
dc.date.accepted2022-06-24


This item appears in the following Collection(s)

Show simple item record