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dc.contributor.authorLausecker, Franziska
dc.contributor.authorLennon, Rachel
dc.contributor.authorRandles, Michael J.
dc.date.accessioned2022-08-01T12:24:56Z
dc.date.available2022-08-01T12:24:56Z
dc.date.issued2022-07-20
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627060/Kidney%20Matrisome.pdf?sequence=5
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627060/PIIS0085253822005440.pdf?sequence=1
dc.identifier.citationLausecker, F., Lennon, R., & Randles, M. J. (2022). The kidney matrisome in health, aging and disease. Kidney International, vol(issue), pp. https://doi.org/10.1016/j.kint.2022.06.029en_US
dc.identifier.issn0085-2538
dc.identifier.doi10.1016/j.kint.2022.06.029
dc.identifier.urihttp://hdl.handle.net/10034/627060
dc.description.abstractDysregulated extracellular matrix is the hallmark of fibrosis, and it has a profound impact on kidney function in disease. Furthermore, perturbation of matrix homeostasis is a feature of aging and is associated with declining kidney function. Understanding these dynamic processes, in the hope of developing therapies to combat matrix dysregulation, requires the integration of data acquired by both well-established and novel technologies. Owing to its complexity, the extracellular proteome, or matrisome, still holds many secrets and has great potential for the identification of clinical biomarkers and drug targets. The molecular resolution of matrix composition during aging and disease has been illuminated by cutting-edge mass spectrometry-based proteomics in recent years, but there remain key questions about the mechanisms that drive altered matrix composition. Basement membrane components are particularly important in the context of kidney function; and data from proteomic studies suggest that switches between basement membrane and interstitial matrix proteins are likely to contribute to organ dysfunction during aging and disease. Understanding the impact of such changes on physical properties of the matrix, and the subsequent cellular response to altered stiffness and viscoelasticity, is of critical importance. Likewise, the comparison of proteomic datasets from multiple organs is required to identify common matrix biomarkers and shared pathways for therapeutic intervention. Coupled with single cell transcriptomics there is the potential to identify the cellular origin of matrix changes, which could enable cell targeted therapy. This review provides a contemporary perspective of the complex kidney matrisome and draws comparison to altered matrix in heart and liver disease.en_US
dc.publisherElsevieren_US
dc.relation.urlhttps://www.kidney-international.org/article/S0085-2538(22)00544-0/fulltexten_US
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
dc.subjectExtracellular matrixen_US
dc.subjectbasement membraneen_US
dc.subjectmass spectrometryen_US
dc.subjectproteomicsen_US
dc.subjectscRNAseqen_US
dc.subjectglomerulusen_US
dc.subjecttubulointerstitiumen_US
dc.subjectfibrosisen_US
dc.subjectmatrix signatureen_US
dc.titleThe kidney matrisome in health, aging and diseaseen_US
dc.typeArticleen_US
dc.identifier.eissn1523-1755en_US
dc.contributor.departmentThe University of Manchester; University of Chesteren_US
dc.identifier.journalKidney Internationalen_US
or.grant.openaccessYesen_US
rioxxterms.funderMJRen_US
rioxxterms.identifier.projectMJRen_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecord10.1016/j.kint.2022.06.029en_US
rioxxterms.licenseref.startdate2023-07-20
dcterms.dateAccepted2022-06-24
rioxxterms.publicationdate2022-07-20
dc.date.deposited2022-08-01en_US
dc.indentifier.issn0085-2538en_US


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