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dc.contributor.authorAgu, P C
dc.contributor.authorAja, P M
dc.contributor.authorEkpono Ugbala, Ezebuilo
dc.contributor.authorOgwoni, H A
dc.contributor.authorEzeh, E M
dc.contributor.authorOscar-Amobi, P C
dc.contributor.authorAsuk Atamgba, Agbor
dc.contributor.authorAni, O G
dc.contributor.authorAwoke, J N
dc.contributor.authorNwite, F E
dc.contributor.authorUkachi, O U
dc.contributor.authorOrji, O U
dc.contributor.authorNweke, P C
dc.contributor.authorEkpono Ugbala, Ejike
dc.contributor.authorEwa, G O
dc.contributor.authorIgwenyi, I O
dc.contributor.authorEgwu, C O
dc.contributor.authorAlum, E U
dc.contributor.authorChukwu, D C
dc.contributor.authorFamurewa, A C
dc.date.accessioned2022-08-01T01:00:47Z
dc.date.available2022-08-01T01:00:47Z
dc.date.issued2022-03-24
dc.date.submitted2021-08-09
dc.identifierpubmed: 35846473
dc.identifierdoi: 10.1016/j.heliyon.2022.e09162
dc.identifierpii: S2405-8440(22)00450-9
dc.identifierpmc: PMC9280550
dc.identifier.citationHeliyon, volume 8, issue 3, page e09162, article-number 10.1016/j.heliyon.2022.e09162
dc.identifier.urihttp://hdl.handle.net/10034/627059
dc.descriptionFrom PubMed via Jisc Publications Router
dc.descriptionHistory: received 2021-08-09, revised 2021-09-14, accepted 2022-03-18
dc.descriptionPublication status: epublish
dc.description.abstractMale reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. [Abstract copyright: © 2022 The Authors. Published by Elsevier Ltd.]
dc.languageeng
dc.sourcepissn: 2405-8440
dc.subjectNutraceuticals
dc.subjectTesticular toxicity
dc.subjectBisphenol A
dc.subjectCucumeropsis mannii
dc.typearticle
dc.date.updated2022-08-01T01:00:47Z
dc.date.accepted2022-03-18


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