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dc.contributor.authorAgu, Peter C.
dc.contributor.authorAja, Patrick M.
dc.contributor.authorEkpono, Ezebuilo U.
dc.contributor.authorOgwoni, Hilary A.
dc.contributor.authorEzeh, E. M.
dc.contributor.authorOscar-Amobi, P. C.
dc.contributor.authorAsuk Atamgba, Agbor
dc.contributor.authorAni, O. G.
dc.contributor.authorAwoke, Joshua N.
dc.contributor.authorNwite, Felix E.
dc.contributor.authorUkachi, O. U.
dc.contributor.authorOrji, Obasi U.
dc.contributor.authorNweke, Peter C.
dc.contributor.authorEkpono, Ejike U.
dc.contributor.authorEwa, G. O.
dc.contributor.authorIgwenyi, Ikechuku O.
dc.contributor.authorEgwu, C. O.
dc.contributor.authorAlum, E. U.
dc.contributor.authorChukwu, Darlington C.
dc.contributor.authorFamurewa, A. C.
dc.date.accessioned2022-08-01T01:00:47Z
dc.date.available2022-08-01T01:00:47Z
dc.date.issued2022-03-24
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/627059/Cucumeropsis%20mannii%20seed%20oil_Heliyon.pdf?sequence=2
dc.identifier.citationAgu, P. C., Aja, P. M., Ekpono Ugbala, E., Ogwoni, H. A., Ezeh, E. M., Oscar-Amobi, P. C., Asuk Atamgba, A., Ani, O. G., Awoke, J. N., Nwite, F. E., Ukachi, O. U., Orji, O. U., Nweke, P. C., Ekpono Ugbala, E., Ewa, G. O., Igwenyi, I. O., Egwu, C. O., Alum, E. U., Chukwu, D. C., Famurewa, A. C. (2022). Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats. Heliyon, 8(3), e09162. https://doi.org/10.1016/j.heliyon.2022.e09162
dc.identifier.doi10.1016/j.heliyon.2022.e09162
dc.identifier.urihttp://hdl.handle.net/10034/627059
dc.description.abstractMale reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. [Abstract copyright: © 2022 The Authors. Published by Elsevier Ltd.]
dc.languageeng
dc.publisherElsevier
dc.relation.urlhttps://www.cell.com/heliyon/fulltext/S2405-8440(22)00450-9
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourcepissn: 2405-8440
dc.subjectNutraceuticals
dc.subjectTesticular toxicity
dc.subjectBisphenol A
dc.subjectCucumeropsis mannii
dc.titleCucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats
dc.typearticle
dc.identifier.eissn2405-8440
dc.contributor.departmentEbonyi State University; Federal Polytechnic Oko; Cross River University of Technology; Alex-Ekwueme Federal University; Caritas University; University of Chester
dc.identifier.journalHeliyon
dc.date.updated2022-08-01T01:00:47Z
dc.date.accepted2022-03-18


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