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    Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats

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    Authors
    Agu, P. C.
    Aja, P. M.
    Ekpono Ugbala, Ezebuilo
    Ogwoni, H. A.
    Ezeh, E. M.
    Oscar-Amobi, P. C.
    Asuk Atamgba, Agbor
    Ani, O. G.
    Awoke, J. N.
    Nwite, F. E.
    Ukachi, O. U.
    Orji, O. U.
    Nweke, P. C.
    Ekpono Ugbala, Ejike
    Ewa, G. O.
    Igwenyi, I. O.
    Egwu, C. O.
    Alum, E. U.
    Chukwu, D. C.
    Famurewa, A. C.
    Show allShow less
    Affiliation
    Ebonyi State University; Federal Polytechnic Oko; Cross River University of Technology; Alex-Ekwueme Federal University; Caritas University; University of Chester
    Publication Date
    2022-03-24
    Submitted date
    2021-08-09
    
    Metadata
    Show full item record
    Abstract
    Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. [Abstract copyright: © 2022 The Authors. Published by Elsevier Ltd.]
    Citation
    Agu, P. C., Aja, P. M., Ekpono Ugbala, E., Ogwoni, H. A., Ezeh, E. M., Oscar-Amobi, P. C., Asuk Atamgba, A., Ani, O. G., Awoke, J. N., Nwite, F. E., Ukachi, O. U., Orji, O. U., Nweke, P. C., Ekpono Ugbala, E., Ewa, G. O., Igwenyi, I. O., Egwu, C. O., Alum, E. U., Chukwu, D. C., Famurewa, A. C. (2022). Cucumeropsis mannii seed oil (CMSO) attenuates alterations in testicular biochemistry and histology against Bisphenol a-induced toxicity in male Wister albino rats. Heliyon, 8(3), e09162. https://doi.org/10.1016/j.heliyon.2022.e09162
    URI
    http://hdl.handle.net/10034/627059
    Additional Links
    https://www.sciencedirect.com/science/article/pii/S2405844022004509
    Type
    article
    Description
    From PubMed via Jisc Publications Router
    History: received 2021-08-09, revised 2021-09-14, accepted 2022-03-18
    Publication status: epublish
    Collections
    Clinical Sciences and Nutrition

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