Authors
Agu, P CAja, P M
Ekpono Ugbala, Ezebuilo
Ogwoni, H A
Ezeh, E M
Oscar-Amobi, P C
Asuk Atamgba, Agbor
Ani, O G
Awoke, J N
Nwite, F E
Ukachi, O U
Orji, O U
Nweke, P C
Ekpono Ugbala, Ejike
Ewa, G O
Igwenyi, I O
Egwu, C O
Alum, E U
Chukwu, D C
Famurewa, A C
Publication Date
2022-03-24Submitted date
2021-08-09
Metadata
Show full item recordAbstract
Male reproductive health has deteriorated in recent years as a result of industrialization, which has led to the use of desirable chemicals, like Bisphenol A (BPA), of underlying toxicity. seed is a common soup thickener that produces vegetable oil as well as essential nutrients making it a source of nutraceuticals enlisted with a wide range of therapeutic effects. A total of 48 adult male Wistar rats (120 ± 200g) were used in this study. They were completely randomized and divided into six groups: A (1ml olive oil) irrespective of the weight, B [BPA 100 mg/kg body weight (bw)], C (CMSO 7.5 ml/kg bw), D (CMSO 7.5 ml/kg bw + BPA 100 mg/kg bw), E (CMSO 5.0 ml/kg bw + BPA 100 mg/kg bw), and E (CMSO 2.5 ml/kg bw + BPA 100 mg/kg bw). At the end of the administration via oral routes, rats were sacrificed and testes were collected for biochemistry and histological analysis. BPA significantly (P < 0.05) decreased total testicular protein, epididymal sperm parameters (count, volume, and motility), Mitochondrial Membrane Potential (MMP), body weight, testicular volume; and significantly (P < 0.05) increased testicular enzymes (alkaline phosphatase and lactate dehydrogenase), testicular index; plus histological damages. Interestingly, co-administration of BPA and CMSO significantly (P < 0.05) reversed the biochemical and histological changes. CMSO prevented the biochemistry and histological alterations hence reducing the testicular toxicity. Therefore, CMSO has the potential to be a promising novel nutraceutical for the treatment and management of BPA-induced testicular toxicity. [Abstract copyright: © 2022 The Authors. Published by Elsevier Ltd.]Citation
Heliyon, volume 8, issue 3, page e09162, article-number 10.1016/j.heliyon.2022.e09162Type
articleDescription
From PubMed via Jisc Publications RouterHistory: received 2021-08-09, revised 2021-09-14, accepted 2022-03-18
Publication status: epublish