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    The effects of prehabilitation on body composition in patients undergoing multimodal therapy for esophageal cancer

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    Authors
    Halliday, Laura J
    Boshier, Piers R
    Doganay, Emre
    Wynter-Blyth, Venetia
    Buckley, John P.
    Moorthy, Krishna
    Publication Date
    2022-07-07
    
    Metadata
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    Abstract
    Summary Prehabilitation aims to optimize a patient’s functional capacity in preparation for surgery. Esophageal cancer patients have a high incidence of sarcopenia and commonly undergo neoadjuvant therapy, which is associated with loss of muscle mass. This study examines the effects of prehabilitation on body composition during neoadjuvant therapy in esophageal cancer patients. In this cohort study, changes in body composition were compared between esophageal cancer patients who participated in prehabilitation during neoadjuvant therapy and controls who did not receive prehabilitation. Assessment of body composition was performed from CT images acquired at the time of diagnosis and after neoadjuvant therapy. Fifty-one prehabilitation patients and 28 control patients were identified. There was a significantly greater fall in skeletal muscle index (SMI) in the control group compared with the prehabilitation patients (Δ SMI mean difference = −2.2 cm2/m2, 95% CI –4.3 to −0.1, p=0.038). Within the prehabilitation cohort, there was a smaller decline in SMI in patients with ≥75% adherence to exercise in comparison to those with lower adherence (Δ SMI mean difference = −3.2, 95% CI –6.0 to −0.5, P = 0.023). A greater decrease in visceral adipose tissue (VAT) was seen with increasing volumes of exercise completed during prehabilitation (P = 0.046). Loss of VAT during neoadjuvant therapy was associated with a lower risk of post-operative complications (P = 0.017). By limiting the fall in SMI and promoting VAT loss, prehabilitation may have multiple beneficial effects in patients with esophageal cancer. Multi-center, randomized studies are needed to further explore these findings.
    Citation
    Diseases of the Esophagus
    Publisher
    Oxford University Press (OUP)
    URI
    http://hdl.handle.net/10034/627025
    Type
    article
    Description
    From Crossref journal articles via Jisc Publications Router
    History: epub 2022-07-07, issued 2022-07-07
    Article version: VoR
    Publication status: Published
    Collections
    Sport and Exercise Sciences

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