Show simple item record

dc.contributor.authorFrancoeur, Rachel
dc.contributor.authorAtuhaire, Alon
dc.contributor.authorArinaitwe, Moses
dc.contributor.authorAdriko, Moses
dc.contributor.authorAjambo, Diana
dc.contributor.authorNankasi, Andrina
dc.contributor.authorBabayan, Simon A.
dc.contributor.authorLamberton, Poppy H. L.
dc.date.accessioned2022-05-17T14:26:12Z
dc.date.available2022-05-17T14:26:12Z
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/626867/microorganisms-09-02448-v2.pdf?sequence=4
dc.identifier.citationFrancoeur, R., Atuhaire, A., Arinaitwe, M., Adriko, M., Ajambo, D., Nankasi, A., Babayan, S., et al. (2021). ABO Blood Groups Do Not Predict Schistosoma mansoni Infection Profiles in Highly Endemic Villages of Uganda. Microorganisms, 9(12), 2448. https://doi.org/10.3390/microorganisms9122448en_US
dc.identifier.urihttp://hdl.handle.net/10034/626867
dc.description.abstractSchistosoma mansoni is a parasite which causes significant public-health issues, with over 240 mil-lion people infected globally. In Uganda alone, approximately 11.6 million people are affected. Despite over a decade of mass drug administration in this country, hyper-endemic hotspots persist, and individuals who are repeatedly heavily and rapidly reinfected are observed. Human blood-type antigens are known to play a role in the risk of infection for a variety of diseases, due to cross-reactivity between host antibodies and pathogenic antigens. There have been conflicting results on the effect of blood type on schistosomiasis infection and pathology. Moreover, the ef-fect of blood type as a potential intrinsic host factor on S. mansoni prevalence, intensity, clearance, and reinfection dynamics and on co-infection risk remains unknown. Therefore, the epidemio-logical link between host blood type and S. mansoni infection dynamics was assessed in three hyper-endemic communities in Uganda. Longitudinal data incorporating repeated pretreatment S. mansoni infection intensities and clearance rates were used to analyse associations between blood groups in school-aged children. Soil-transmitted helminth coinfection status and biometric parameters were incorporated in a generalised linear mixed regression model including age, gender, and body mass index (BMI), which have previously been established as significant factors influencing the prevalence and intensity of schistosomiasis. The analysis revealed no associations between blood type and S. mansoni prevalence, infection intensity, clearance, reinfection, or coinfection. Variations in infection profiles were significantly different between the villages, and egg burden significantly decreased with age. While blood type has proven to be a predictor of several diseases, the data collected in this study indicate that it does not play a significant role in S. mansoni infection burdens in these high-endemicity communities.en_US
dc.publisherMDPIen_US
dc.relation.urlhttps://www.mdpi.com/2076-2607/9/12/2448en_US
dc.rightsAttribution-ShareAlike 4.0 International*
dc.rights.uri(https:// creativecommons.org/licenses/by/4.0/en_US
dc.subjectSchistosomiasisen_US
dc.subjectblood groupen_US
dc.subjectsusceptibilityen_US
dc.subjectrhesusen_US
dc.subjectcoinfectionen_US
dc.subjectSTHen_US
dc.titleABO Blood Groups Do Not Predict Schistosoma mansoni Infection Profiles in Highly Endemic Villages of Ugandaen_US
dc.typeArticleen_US
dc.identifier.eissn2076-2607en_US
dc.contributor.departmentUniversity of Glasgow; University of Chester; Ministry of Health, Ugandaen_US
dc.identifier.journalMicroorganismsen_US
or.grant.openaccessYesen_US
rioxxterms.funderEuropean Research Council (ERC) 680088/17286en_US
rioxxterms.identifier.projectERC grant, Lamberton, 2017/22, Project Name SCHISTO-PERSIST, Project Code 172876, Funder Ref 680088en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecord10.3390/microorganisms9122448en_US
rioxxterms.licenseref.startdate2022-05-17
dcterms.dateAccepted2021-11-27
rioxxterms.publicationdate2021-11-27
dc.date.deposited15/5/2022en_US
dc.indentifier.issn2076-2607en_US


Files in this item

Thumbnail
Name:
microorganisms-09-02448-v2.pdf
Size:
1.145Mb
Format:
PDF
Request:
Main article (VoR)

This item appears in the following Collection(s)

Show simple item record

Attribution-ShareAlike 4.0 International
Except where otherwise noted, this item's license is described as Attribution-ShareAlike 4.0 International