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    Effectiveness of Roflumilast in Treating Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis.

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    Authors
    Naseem, Sumbal
    Hassan, Muhammad
    Akhtar, Shazia Nasim
    Syed, Fibhaa
    Khan, Naveed Ullah
    Usman, Muhammad
    Publication Date
    2022-03-04
    
    Metadata
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    Abstract
    Background Chronic obstructive pulmonary disease (COPD) is a chronic airflow obstructive condition. The mainstay of treatment is to avoid exacerbation and manage the symptoms. Roflumilast is being used as a part of treatment to reduce the inflammatory process in this disease. Method This systematic review and meta-analysis were conducted following the provided guidelines. PubMed, Cochrane Library, and Cinahl were considered for searching the desired studies selected until 19 June 2021. The eligibility criteria for inclusion and exclusion were set before selecting studies. Result Five hundred eighty (580) studies were identified at the beginning. Removal of duplicates was done using Endnote software. The eligibility criteria, including the randomized controlled trial study design and others, were applied for screening the title and abstracts. Six studies were selected for the qualitative analysis. After assessing the data from these studies, it was found that roflumilast is an effective drug to treat COPD. Roflumilast plays an essential role in improving quality of life, inflammatory process, and clinical improvement. The drug's mild to moderate adverse effects were observed, but no significant severe adverse events were reported, and the drug was well tolerated. Conclusion Roflumilast is a valuable drug that can be used for its beneficial effects on COPD exacerbation. The benefits of the drug outweigh its adverse effects. [Abstract copyright: Copyright © 2022, Naseem et al.]
    Citation
    Cureus, volume 14, issue 3, page e22843
    URI
    http://hdl.handle.net/10034/626811
    Type
    article
    Description
    From PubMed via Jisc Publications Router
    History: accepted 2022-03-03
    Publication status: epublish
    Collections
    Chester Medical School

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