Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population
dc.contributor.author | Isgin-Atici, Kubra | |
dc.contributor.author | Alathari, Buthaina E. | |
dc.contributor.author | Turan-Demirci, Busra | |
dc.contributor.author | Sendur, Suleyman Nahit | |
dc.contributor.author | Incilay, Lay | |
dc.contributor.author | Ellahi, Basma | |
dc.contributor.author | Alikasifoglu, Mehmet | |
dc.contributor.author | Erbas, Tomris | |
dc.contributor.author | Buyuktuncer, Zehra | |
dc.contributor.author | Santhanakrishnan, Vimaleswaran Karani | |
dc.date.accessioned | 2022-04-11T10:47:49Z | |
dc.date.available | 2022-04-11T10:47:49Z | |
dc.date.issued | 2022-01-17 | |
dc.identifier | https://chesterrep.openrepository.com/bitstream/handle/10034/626800/nutrients-14-00382-v2.pdf?sequence=4 | |
dc.identifier | https://chesterrep.openrepository.com/bitstream/handle/10034/626800/karani%20et%20al%202022%20original_manuscript%20%20%28002%29.pdf?sequence=3 | |
dc.identifier.citation | Isgin-Atici, K., Alathari, B. E., Turan-Demirci, B., Sendur, S. N., Incilay, L., Ellahi, B., Alikasifoglu, M., Erbas, T., Buyuktuncer, Z., & Vimaleswaran, K. S. (2022). Interaction between dietary fat Intake and metabolic genetic risk score on 25-Hydroxyvitamin D Concentrations in a Turkish adult population. Nutrients, 14(2), 382. https://doi.org/10.3390/nu14020382 | en_US |
dc.identifier.issn | No print ISSN | |
dc.identifier.doi | 10.3390/nu14020382 | |
dc.identifier.uri | http://hdl.handle.net/10034/626800 | |
dc.description.abstract | Previous studies have pointed out a link between vitamin D status and metabolic traits, however, consistent evidence has not been provided yet. This cross-sectional study has used a nutrigenetic approach to investigate the interaction between metabolic-genetic risk score (GRS) and dietary intake on serum 25-hydroxyvitamin D [25(OH)D] concentrations in 396 unrelated Turkish adults, aged 24-50 years. Serum 25(OH)D concentration was significantly lower in those with a metabolic-GRS ≥ 1 risk allele than those with a metabolic-GRS < 1 risk allele (p = 0.020). A significant interaction between metabolic-GRS and dietary fat intake (energy%) on serum 25(OH)D levels was identified (Pinteraction = 0.040). Participants carrying a metabolic-GRS ≥ 1 risk allele and consuming a high fat diet (≥38% of energy = 122.3 ± 52.51 g/day) had significantly lower serum 25(OH)D concentration (p = 0.006) in comparison to those consuming a low-fat diet (<38% of energy = 82.5 ± 37.36 g/d). In conclusion, our study suggests a novel interaction between metabolic-GRS and dietary fat intake on serum 25(OH)D level, which emphasises that following the current dietary fat intake recommendation (<35% total fat) could be important in reducing the prevalence of vitamin D deficiency in this Turkish population. Nevertheless, further larger studies are needed to verify this interaction, before implementing personalized dietary recommendations for the maintenance of optimal vitamin D status. | en_US |
dc.publisher | MDPI | en_US |
dc.relation.url | https://www.mdpi.com/2072-6643/14/2/382 | en_US |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | en_US |
dc.subject | vitamin D | en_US |
dc.subject | MC4R | en_US |
dc.subject | TCF7L2 | en_US |
dc.subject | fat intake | en_US |
dc.subject | genetic risk score | en_US |
dc.subject | metabolic traits | en_US |
dc.title | Interaction between Dietary Fat Intake and Metabolic Genetic Risk Score on 25-Hydroxyvitamin D Concentrations in a Turkish Adult Population | en_US |
dc.type | Article | en_US |
dc.identifier.eissn | 2072-6643 | en_US |
dc.contributor.department | Hacettepe University; Amasya University; University of Reading; The Public Authority for Applied Education and Training; Hacettepe University Hospitals; University of Chester; Genetics Diagnostic Centre | en_US |
dc.identifier.journal | Nutrients | en_US |
or.grant.openaccess | Yes | en_US |
rioxxterms.funder | Scientific and Technological Research Council of Turkey (TUBITAK) and Council of Higher Education of Turkey | en_US |
rioxxterms.identifier.project | none | en_US |
rioxxterms.version | AM | en_US |
rioxxterms.versionofrecord | 10.3390/nu14020382 | en_US |
dcterms.dateAccepted | 2022-01-14 | |
rioxxterms.publicationdate | 2022-01-17 | |
dc.date.deposited | 2022-04-11 | en_US |
dc.indentifier.issn | No print ISSN | en_US |