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    New challenges for an expanding generation of older persons with haemophilia

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    Authors
    O’Hara, Jamie
    Noone, Declan
    Kritikou, Persefoni
    Myren, Karl-Johan
    Chaplin, Steve
    Hart, Daniel P.
    Publication Date
    2022-03-09
    
    Metadata
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    Abstract
    Abstract Background Increasing survival among people with haemophilia means that more individuals are at risk of developing age-related morbidity. Little is known about morbidity and health-related quality of life (HRQoL) in different age groups within a single large population of people with haemophilia. Aim This study aimed to explore the association between increasing age and comorbidity among people with haemophilia and to compare their HRQoL with that of a sample of the general population in England. Methods The prevalence of comorbidity recorded in medical records and HRQoL assessed by EQ-5D were compared by age group in participants in the Cost of Haemophilia in Europe: A Socioeconomic Survey study (CHESS) in Europe. HRQoL was compared with that of a sample of the general population taken from the 2012 Health Survey for England (HSE). Results Younger adults in CHESS were more likely to have received prophylaxis from an early age. The mean number of affected joints in younger adults was 1.0; participants aged 41–50 (1.25) and 51–60 years (1.41) had the highest mean number of affected joints. The prevalence of comorbidity was 36% in patients aged 18–30, 61% in 31–60-year-olds and 68% in those aged 61+. HRQoL impairment in young adults with haemophilia was comparable with that in the HSE population aged over 60. Conclusions Older people with haemophilia have impaired quality of life compared with younger adults and an increasing prevalence of several age-related disorders affecting mental health and cardiovascular and bone health. Young adults with haemophilia report impaired HRQoL comparable with that in a general population aged 61+.
    Citation
    The Journal of Haemophilia Practice, volume 9, issue 1, page 1-13
    Publisher
    Walter de Gruyter GmbH
    URI
    http://hdl.handle.net/10034/626774
    Type
    article
    Description
    From Crossref journal articles via Jisc Publications Router
    History: ppub 2022-01-01, issued 2022-01-01, epub 2022-03-09
    Publication status: Published
    Collections
    Health and Social Care

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