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dc.contributor.authorRousselle, Christophe
dc.contributor.authorMeslin, Matthieu
dc.contributor.authorBerman, Tamar
dc.contributor.authorWoutersen, Marjolijn
dc.contributor.authorBil, Wieneke
dc.contributor.authorWildeman, Jenna
dc.contributor.authorChaudhry, Qasim
dc.date.accessioned2022-02-21T03:30:07Z
dc.date.available2022-02-21T03:30:07Z
dc.date.issued2022-02-19
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/626702/toxics-10-00096.pdf?sequence=3
dc.identifier.citationRousselle, C., Meslin, M., Berman, T., Woutersen, M., Bil, W., Wildeman, J., & Chaudhry, Q. (2022). Using human biomonitoring data to support risk assessment of cosmetic ingredients—A case study of Benzophenone-3. Toxics, 10(2), e96. https://doi.org/10.3390/toxics10020096
dc.identifier.urihttp://hdl.handle.net/10034/626702
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2022-02-16, pub-electronic 2022-02-19
dc.descriptionPublication status: Published
dc.descriptionFunder: European Union; Grant(s): 733032
dc.description.abstractSafety assessment of UV filters for human health by the Scientific Committee on Consumer Safety (SCCS) is based on the estimation of internal dose following external (skin) application of cosmetic products, and comparison with a toxicological reference value after conversion to internal dose. Data from human biomonitoring (HBM) could be very useful in this regard, because it is based on the measurement of real-life internal exposure of the human population to a chemical. UV filters were included in the priority list of compounds to be addressed under the European Human Biomonitoring Initiative (HBM4EU), and risk assessment of benzophenone-3 (BP-3) was carried out based on HBM data. Using BP-3 as an example, this study investigated the benefits and limitations of the use of external versus internal exposure data to explore the usefulness of HBM to support the risk assessment of cosmetic ingredients. The results show that both approaches did indicate a risk to human health under certain levels of exposure. They also highlight the need for more robust exposure data on BP-3 and other cosmetic ingredients, and a standardized framework for incorporating HBM data in the risk assessment of cosmetic products.
dc.languageen
dc.publisherMDPI
dc.relation.urlhttps://www.mdpi.com/2305-6304/10/2/96
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2305-6304
dc.subjecthuman biomonitoring
dc.subjectUV filters
dc.subjectbenzophenone-3
dc.subjectHBM4EU
dc.subjectrisk assessment
dc.subjectRCR
dc.subjectmargin of safety
dc.titleUsing Human Biomonitoring Data to Support Risk Assessment of Cosmetic Ingredients—A Case Study of Benzophenone-3
dc.typearticle
dc.contributor.departmentEuropean and International Affairs Department, Anses; Risk Assessment Department, Anses; Ministry of Health, Jerusalem; RIVM National Institute for Public Health and the Environment; University of Chester
dc.date.updated2022-02-21T03:30:07Z
dc.date.accepted2022-02-16


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