Use of long-acting injectable antiretroviral agents for human immunodeficiency Virus: A review
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AbstractThe development of potent antiretroviral drugs has significantly reduced morbidity and mortality associated with human immunodeficiency virus infection, however, the effectiveness of these medications depends upon consistent daily oral intake. Non-adherence can lead to the emergence of resistance, treatment failure and disease progression. This has necessitated the development of long-acting antiretroviral formulations administrable via an infrequent dosing regimen. Long-acting injectable forms of cabotegravir and rilpivirine have reached various stages in clinical trials both for the treatment and prevention of HIV. Other long-acting agents are at various stages of development. This review evaluates the current research on the development of long-acting injectable antiretroviral agents for the treatment and prevention of HIV.
CitationJournal of Clinical Virology, volume 146, page 105032
DescriptionFrom Elsevier via Jisc Publications Router
History: accepted 2021-11-21, epub 2021-12-06, issued 2022-01-31
Article version: AM
Publication status: Published