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dc.contributor.authorKiraly, Peter; orcid: 0000-0003-3540-4876
dc.contributor.authorDal Poggetto, Guilherme; orcid: 0000-0003-0591-9166
dc.contributor.authorCastañar, Laura; orcid: 0000-0002-4731-0626
dc.contributor.authorNilsson, Mathias; orcid: 0000-0003-3301-7899
dc.contributor.authorDeák, Andrea; orcid: 0000-0001-7988-0255
dc.contributor.authorMorris, Gareth A; orcid: 0000-0002-4859-6259
dc.date.accessioned2021-11-25T02:01:07Z
dc.date.available2021-11-25T02:01:07Z
dc.date.issued2021-08-03
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/626433/article.pdf?sequence=2
dc.identifier.citationChemical science, volume 12, issue 34, page 11538-11547
dc.identifier.urihttp://hdl.handle.net/10034/626433
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: epub 2021-08-03, ppub 2021-09-01
dc.descriptionPublication status: Published
dc.description.abstractAccurate measurement of transverse relaxation rates in coupled spin systems is important in the study of molecular dynamics, but is severely complicated by the signal modulations caused by scalar couplings in spin echo experiments. The most widely used experiments for measuring transverse relaxation in coupled systems, CPMG and PROJECT, can suppress such modulations, but they also both suppress some relaxation contributions, and average relaxation rates between coupled spins. Here we introduce a new experiment which for the first time allows accurate broadband measurement of transverse relaxation rates of coupled protons, and hence the determination of exchange rate constants in slow exchange from relaxation measurements. The problems encountered with existing methods are illustrated, and the use of the new method is demonstrated for the classic case of hindered amide rotation and for the more challenging problem of exchange between helical enantiomers of a gold(i) complex.
dc.languageeng
dc.rightsLicence for this article: cc by
dc.sourceessn: 2041-6539
dc.sourcenlmid: 101545951
dc.sourceissn: 2041-6520
dc.titleBroadband measurement of true transverse relaxation rates in systems with coupled protons: application to the study of conformational exchange.
dc.typearticle
dc.date.updated2021-11-25T02:01:07Z


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