Breath and plasma metabolomics to assess inflammation in acute stroke
White, Iain R.
Johnson, Craig F.
Kishore, Amit K.
Smith, Craig J.; email: Craig.Smithemail@example.com
Fowler, Stephen J.; email: Stephen.Fowler@manchester.ac.uk
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AbstractAbstract: Inflammation is strongly implicated in both injury and repair processes occurring after stroke. In this exploratory study we assessed the feasibility of repeated sampling of exhaled volatile organic compounds and performed an untargeted metabolomic analysis of plasma collected at multiple time periods after stroke. Metabolic profiles were compared with the time course of the inflammatory markers C-reactive protein (CRP) and interleukin-6 (IL-6). Serial breath sampling was well-tolerated by all patients and the measurement appears feasible in this group. We found that exhaled decanal tracks CRP and IL-6 levels post-stroke and correlates with several metabolic pathways associated with a post-stroke inflammatory response. This suggests that measurement of breath and blood metabolites could facilitate development of novel therapeutic and diagnostic strategies. Results are discussed in relation to the utility of breath analysis in stroke care, such as in monitoring recovery and complications including stroke associated infection.
CitationScientific Reports, volume 11, issue 1, page 21949
PublisherNature Publishing Group UK
DescriptionFrom Springer Nature via Jisc Publications Router
History: received 2021-04-27, accepted 2021-09-27, registration 2021-10-26, pub-electronic 2021-11-09, online 2021-11-09, collection 2021-12
Publication status: Published
Funder: Moulton Charitable Trust
Funder: Manchester Biomedical Research Centre; doi: http://dx.doi.org/10.13039/100014653