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dc.contributor.authorFlores-Téllez, Teresita Del N J
dc.contributor.authorBaena, Esther; email: esther.baena@cruk.manchester.ac.uk
dc.date.accessioned2021-11-07T01:46:40Z
dc.date.available2021-11-07T01:46:40Z
dc.date.issued2021-10-21
dc.date.submitted2021-06-18
dc.identifierpubmed: 34688843
dc.identifierpii: S0304-3835(21)00522-X
dc.identifierdoi: 10.1016/j.canlet.2021.10.012
dc.identifier.citationCancer letters, volume 524, page 194-205
dc.identifier.urihttp://hdl.handle.net/10034/626292
dc.descriptionFrom PubMed via Jisc Publications Router
dc.descriptionHistory: received 2021-06-18, revised 2021-09-23, accepted 2021-10-09
dc.descriptionPublication status: aheadofprint
dc.description.abstractTumor heterogeneity plays a key role in prostate cancer prognosis, therapy selection, relapse, and acquisition of treatment resistance. Prostate cancer presents a heterogeneous diversity at inter- and intra-tumor and inter-patient levels which are influenced by multiple intrinsic and/or extrinsic factors. Recent studies have started to characterize the complexity of prostate tumors and these different tiers of heterogeneity. In this review, we discuss the most common factors that contribute to tumoral diversity. Moreover, we focus on the description of the in vitro and in vivo approaches, as well as high-throughput technologies, that help to model intra-tumoral diversity. Further understanding tumor heterogeneities and the challenges they present will guide enhanced patient risk stratification, aid the design of more precise therapies, and ultimately help beat this chameleon-like disease. [Abstract copyright: Copyright © 2021. Published by Elsevier B.V.]
dc.languageeng
dc.sourceeissn: 1872-7980
dc.subjectExtrinsic factors
dc.subjectProstate tumors
dc.subjectIntra-tumor heterogeneity
dc.subjectCellular and molecular heterogeneity
dc.titleExperimental challenges to modeling prostate cancer heterogeneity.
dc.typearticle
dc.date.updated2021-11-07T01:46:40Z
dc.date.accepted2021-10-09


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