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dc.contributor.authorGiachello, Carlo N. G.
dc.contributor.authorFan, Yuen Ngan
dc.contributor.authorLandgraf, Matthias
dc.contributor.authorBaines, Richard A.; email: Richard.Baines@manchester.ac.uk
dc.date.accessioned2021-10-13T15:23:35Z
dc.date.available2021-10-13T15:23:35Z
dc.date.issued2021-10-13
dc.date.submitted2021-07-29
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/626094/41598_2021_Article_99868_nlm.xml?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/626094/41598_2021_99868_MOESM1_ESM.pdf?sequence=3
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/626094/41598_2021_Article_99868.pdf?sequence=4
dc.identifier.citationScientific Reports, volume 11, issue 1, page 20286
dc.identifier.urihttp://hdl.handle.net/10034/626094
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2021-07-29, accepted 2021-09-17, registration 2021-10-05, online 2021-10-13, pub-electronic 2021-10-13, collection 2021-12
dc.descriptionPublication status: Published
dc.descriptionFunder: Biotechnology and Biological Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000268; Grant(s): BB/N/014561/1, BB/R016666/1
dc.descriptionFunder: Wellcome Trust; doi: http://dx.doi.org/10.13039/100010269; Grant(s): 217099/Z/19/Z
dc.description.abstractAbstract: The emergence of coordinated network function during nervous system development is often associated with critical periods. These phases are sensitive to activity perturbations during, but not outside, of the critical period, that can lead to permanently altered network function for reasons that are not well understood. In particular, the mechanisms that transduce neuronal activity to regulating changes in neuronal physiology or structure are not known. Here, we take advantage of a recently identified invertebrate model for studying critical periods, the Drosophila larval locomotor system. Manipulation of neuronal activity during this critical period is sufficient to increase synaptic excitation and to permanently leave the locomotor network prone to induced seizures. Using genetics and pharmacological manipulations, we identify nitric oxide (NO)-signaling as a key mediator of activity. Transiently increasing or decreasing NO-signaling during the critical period mimics the effects of activity manipulations, causing the same lasting changes in synaptic transmission and susceptibility to seizure induction. Moreover, the effects of increased activity on the developing network are suppressed by concomitant reduction in NO-signaling and enhanced by additional NO-signaling. These data identify NO signaling as a downstream effector, providing new mechanistic insight into how activity during a critical period tunes a developing network.
dc.languageen
dc.publisherNature Publishing Group UK
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2045-2322
dc.subjectArticle
dc.subject/631/378/2571
dc.subject/631/378/340
dc.subject/631/378/3920
dc.subject/631/378/2591
dc.subject/631/136
dc.subject/631/378
dc.subjectarticle
dc.titleNitric oxide mediates activity-dependent change to synaptic excitation during a critical period in Drosophila
dc.typearticle
dc.date.updated2021-10-13T15:23:35Z
dc.date.accepted2021-09-17


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