• Login / Register
    View Item 
    •   Home
    • Support Departments
    • Harvested data
    • View Item
    •   Home
    • Support Departments
    • Harvested data
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChesterRepCommunitiesTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalProfilesView

    My Account

    LoginRegister

    About

    AboutUniversity of Chester

    Statistics

    Display statistics

    Radical hydroxymethylation of alkyl iodides using formaldehyde as a C1 synthon.

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    article.pdf
    Size:
    1.691Mb
    Format:
    PDF
    Download
    Authors
    Caiger, Lewis; orcid: 0000-0001-5156-9684
    Sinton, Conar; orcid: 0000-0002-5588-7548
    Constantin, Timothée; orcid: 0000-0001-5376-1557
    Douglas, James J
    Sheikh, Nadeem S
    Juliá, Fabio; orcid: 0000-0001-8903-4482
    Leonori, Daniele; orcid: 0000-0002-7692-4504
    Publication Date
    2021-07-06
    
    Metadata
    Show full item record
    Abstract
    Radical hydroxymethylation using formaldehyde as a C1 synthon is challenging due to the reversible and endothermic nature of the addition process. Here we report a strategy that couples alkyl iodide building blocks with formaldehyde through the use of photocatalysis and a phosphine additive. Halogen-atom transfer (XAT) from α-aminoalkyl radicals is leveraged to convert the iodide into the corresponding open-shell species, while its following addition to formaldehyde is rendered irreversible by trapping the transient O-radical with PPh<sub>3</sub>. This event delivers a phosphoranyl radical that re-generates the alkyl radical and provides the hydroxymethylated product.
    Citation
    Chemical science, volume 12, issue 31, page 10448-10454
    URI
    http://hdl.handle.net/10034/625952
    Type
    article
    Description
    From Europe PMC via Jisc Publications Router
    History: epub 2021-07-06, ppub 2021-08-01
    Publication status: Published
    Funder: European Research Council; Grant(s): 758427
    Collections
    Harvested data

    entitlement

     

    Related items

    Showing items related by title, author, creator and subject.

    • Thumbnail

      Publisher Correction: Situational factors shape moral judgements in the trolley dilemma in Eastern, Southern and Western countries in a culturally diverse sample.

      Bago, Bence; orcid: 0000-0001-6905-1832; Kovacs, Marton; orcid: 0000-0002-8142-8492; Protzko, John; orcid: 0000-0001-5710-8635; Nagy, Tamas; orcid: 0000-0001-5244-0356; Kekecs, Zoltan; orcid: 0000-0001-9247-9781; Palfi, Bence; orcid: 0000-0002-6739-8792; Adamkovic, Matus; Adamus, Sylwia; orcid: 0000-0002-7399-8735; Albalooshi, Sumaya; orcid: 0000-0002-3826-4795; Albayrak-Aydemir, Nihan; orcid: 0000-0003-3412-4311; et al. (2022-06-06)
    • Thumbnail

      New insights into Perrault syndrome, a clinically and genetically heterogeneous disorder.

      Faridi, Rabia; orcid: 0000-0001-7788-8755; Rea, Alessandro; orcid: 0000-0002-6204-846X; Fenollar-Ferrer, Cristina; orcid: 0000-0003-4953-8891; O'Keefe, Raymond T; orcid: 0000-0001-8764-1289; Gu, Shoujun; Munir, Zunaira; orcid: 0000-0003-3342-9658; Khan, Asma Ali; orcid: 0000-0002-0894-3439; Riazuddin, Sheikh; orcid: 0000-0001-6012-0192; Hoa, Michael; orcid: 0000-0001-7469-2909; Naz, Sadaf; orcid: 0000-0002-1912-0235; et al. (2021-08-02)
      Hearing loss and impaired fertility are common human disorders each with multiple genetic causes. Sometimes deafness and impaired fertility, which are the hallmarks of Perrault syndrome, co-occur in a person. Perrault syndrome is inherited as an autosomal recessive disorder characterized by bilateral mild to severe childhood sensorineural hearing loss with variable age of onset in both sexes and ovarian dysfunction in females who have a 46, XX karyotype. Since the initial clinical description of Perrault syndrome 70 years ago, the phenotype of some subjects may additionally involve developmental delay, intellectual deficit and other neurological disabilities, which can vary in severity in part dependent upon the genetic variants and the gene involved. Here, we review the molecular genetics and clinical phenotype of Perrault syndrome and focus on supporting evidence for the eight genes (CLPP, ERAL1, GGPS1, HARS2, HSD17B4, LARS2, RMND1, TWNK) associated with Perrault syndrome. Variants of these eight genes only account for approximately half of the individuals with clinical features of Perrault syndrome where the molecular genetic base remains under investigation. Additional environmental etiologies and novel Perrault disease-associated genes remain to be identified to account for unresolved cases. We also report a new genetic variant of CLPP, computational structural insight about CLPP and single cell RNAseq data for eight reported Perrault syndrome genes suggesting a common cellular pathophysiology for this disorder. Some unanswered questions are raised to kindle future research about Perrault syndrome. [Abstract copyright: © 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.]
    • Thumbnail

      Risk Governance of Emerging Technologies Demonstrated in Terms of its Applicability to Nanomaterials.

      Isigonis, Panagiotis; orcid: 0000-0002-8404-7708; Afantitis, Antreas; Antunes, Dalila; Bartonova, Alena; Beitollahi, Ali; Bohmer, Nils; Bouman, Evert; Chaudhry, Qasim; Cimpan, Mihaela Roxana; Cimpan, Emil; et al. (2020-07-23)
      Nanotechnologies have reached maturity and market penetration that require nano-specific changes in legislation and harmonization among legislation domains, such as the amendments to REACH for nanomaterials (NMs) which came into force in 2020. Thus, an assessment of the components and regulatory boundaries of NMs risk governance is timely, alongside related methods and tools, as part of the global efforts to optimise nanosafety and integrate it into product design processes, via Safe(r)-by-Design (SbD) concepts. This paper provides an overview of the state-of-the-art regarding risk governance of NMs and lays out the theoretical basis for the development and implementation of an effective, trustworthy and transparent risk governance framework for NMs. The proposed framework enables continuous integration of the evolving state of the science, leverages best practice from contiguous disciplines and facilitates responsive re-thinking of nanosafety governance to meet future needs. To achieve and operationalise such framework, a science-based Risk Governance Council (RGC) for NMs is being developed. The framework will provide a toolkit for independent NMs' risk governance and integrates needs and views of stakeholders. An extension of this framework to relevant advanced materials and emerging technologies is also envisaged, in view of future foundations of risk research in Europe and globally. [Abstract copyright: © 2020 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.]
    DSpace software (copyright © 2002 - 2022)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.