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dc.contributor.authorSalcman, Barbora; email: barbora.salcman@postgrad.manchester.ac.uk
dc.contributor.authorAffleck, Karen; email: karen.x.affleck@gsk.com
dc.contributor.authorBulfone-Paus, Silvia; orcid: 0000-0002-5764-8516; email: silvia.bulfone-paus@manchester.ac.uk
dc.date.accessioned2021-09-03T23:31:49Z
dc.date.available2021-09-03T23:31:49Z
dc.date.issued2021-09-02
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625776/additional-files.zip?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625776/cells-10-02282.pdf?sequence=3
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625776/cells-10-02282.xml?sequence=4
dc.identifier.citationCells, volume 10, issue 9, page e2282
dc.identifier.urihttp://hdl.handle.net/10034/625776
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2021-08-30, pub-electronic 2021-09-02
dc.descriptionPublication status: Published
dc.descriptionFunder: Biotechnology and Biological Sciences Research Council; Grant(s): BB/R505699/1
dc.description.abstractLocalisation of mast cells (MCs) at the abluminal side of blood vessels in the brain favours their interaction with glial cells, neurons, and endothelial cells, resulting in the activation of these cells and the release of pro-inflammatory mediators. In turn, stimulation of glial cells, such as microglia, astrocytes, and oligodendrocytes may result in the modulation of MC activities. MCs, microglia, astrocytes, and oligodendrocytes all express P2X receptors (P2XRs) family members that are selectively engaged by ATP. As increased concentrations of extracellular adenosine 5′-triphosphate (ATP) are present in the brain in neuropathological conditions, P2XR activation in MCs and glial cells contributes to the control of their communication and amplification of the inflammatory response. In this review we discuss P2XR-mediated MC activation, its bi-directional effect on microglia, astrocytes and oligodendrocytes and role in neuroinflammation.
dc.languageen
dc.publisherMDPI
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 2073-4409
dc.subjectmast cells
dc.subjectmicroglia
dc.subjectastrocytes
dc.subjectoligodendrocytes
dc.subjectP2X receptors
dc.titleP2X Receptor-Dependent Modulation of Mast Cell and Glial Cell Activities in Neuroinflammation
dc.typearticle
dc.date.updated2021-09-03T23:31:49Z
dc.date.accepted2021-08-30


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