• Login / Register
    View Item 
    •   Home
    • Support Departments
    • Harvested data
    • View Item
    •   Home
    • Support Departments
    • Harvested data
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

    All of ChesterRepCommunitiesTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalThis CollectionTitleAuthorsPublication DateSubmit DateSubjectsPublisherJournalProfilesView

    My Account

    LoginRegister

    About

    AboutUniversity of Chester

    Statistics

    Display statistics

    The promise and challenges of cell therapy for psoriasis

    • CSV
    • RefMan
    • EndNote
    • BibTex
    • RefWorks
    Thumbnail
    Name:
    bjd.20517.xml
    Size:
    7.899Kb
    Format:
    XML
    Download
    Thumbnail
    Name:
    bjd.20517.pdf
    Size:
    815.0Kb
    Format:
    PDF
    Download
    Authors
    Lwin, S.M.; orcid: 0000-0002-3325-3675
    Snowden, J.A.; orcid: 0000-0001-6819-3476
    Griffiths, C.E.M.; orcid: 0000-0001-5371-4427; email: christopher.griffiths@manchester.ac.uk
    Publication Date
    2021-07-27
    
    Metadata
    Show full item record
    Abstract
    Summary: The management of moderate‐to‐severe psoriasis has been transformed by the introduction of biological therapies. These medicines, particularly those targeting interleukin (IL)‐17 and IL‐23p19, can offer clear or nearly clear skin for the majority of patients with psoriasis, with good long‐term drug survival. However, as currently used, none of these therapies is curative and disconcertingly there is a small but increasing number of patients with severe psoriasis who have failed all currently available therapeutic modalities. A similar scenario has occurred in other immune‐mediated inflammatory diseases (IMIDs) where treatment options are limited in severely affected patients. In these cases, cell therapy, including haematopoietic stem cell transplantation (HSCT) and mesenchymal stromal cells (MSC), has been utilized. This review discusses the various forms of cell therapy currently available, their utility in the management of IMIDs and emerging evidence for efficacy in severe psoriasis that is unresponsive to biological therapy. Balancing the risks and benefits of treatment vs. the underlying disease is key; cell therapy carries significant risks, costs, regulation and other complexities, which must be justified by outcomes. Although HSCT has anecdotally been reported to benefit severe psoriasis, sometimes with apparent cure, this has mainly been in the setting of other coincidental ‘routine’ indications. In psoriasis, cell therapies, such as MSC and regulatory T cells, with a lower risk of complications are likely to be more appropriate. Well‐designed controlled trials coupled with mechanistic studies are warranted if advanced cell therapies are to be developed and delivered as a realistic option for severe psoriasis.
    Citation
    British Journal of Dermatology
    URI
    http://hdl.handle.net/10034/625406
    Type
    article
    Description
    From Wiley via Jisc Publications Router
    History: accepted 2021-05-18, pub-electronic 2021-07-27
    Article version: VoR
    Publication status: Published
    Funder: NIHR Manchester Biomedical Research Centre; Id: http://dx.doi.org/10.13039/100014653
    Collections
    Harvested data

    entitlement

     
    DSpace software (copyright © 2002 - 2023)  DuraSpace
    Quick Guide | Contact Us
    Open Repository is a service operated by 
    Atmire NV
     

    Export search results

    The export option will allow you to export the current search results of the entered query to a file. Different formats are available for download. To export the items, click on the button corresponding with the preferred download format.

    By default, clicking on the export buttons will result in a download of the allowed maximum amount of items.

    To select a subset of the search results, click "Selective Export" button and make a selection of the items you want to export. The amount of items that can be exported at once is similarly restricted as the full export.

    After making a selection, click one of the export format buttons. The amount of items that will be exported is indicated in the bubble next to export format.