The Neural Correlates of a Central Coherence Task in Young Women with Anorexia Nervosa
Authors
Leslie, MonicaHalls, Daniel
Leppanen, Jenni
Sedgewick, Felicity
Lang, Katie
Fonville, Leon
Simic, Mima
Mandy, William
Nicholls, Dasha
Williams, Steven
Tchanturia, Kate
Affiliation
University of Chester; King's College London; University of Bristol; Imperial College London; South London and Maudsley NHS Foundation Trust; University College London; Illia State UniversityPublication Date
2021-07-18
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Neural Correlates of Central Coherence in Anorexia NervosaAbstract
Objective: Heightened detail-processing and low levels of central coherence are common in individuals with anorexia nervosa (AN) and predict poorer prognosis. However, it is unclear whether these processing styles predate the disorder or, rather, emerge during later stages of AN. The current study aimed to address this question by investigating central coherence, and the neural correlates of central coherence, in a sample of young women with AN with shorter duration of illness than previous studies recruiting adult samples. Methods: We recruited 186 participants, including: 73 young women with AN, 45 young women weight-recovered from AN, and 68 age-matched controls. Participants completed the Embedded Figures Task during an fMRI scan. Results: There were no significant differences between the participant groups in performance accuracy or reaction time. There were no other between-groups differences in neural response to the Embedded Figures Task. Conclusions: These findings contrast with evidence from older adults demonstrating differences in the neural underpinning of central coherence amongst participants with AN versus control participants. The current study adds to an increasing literature base demonstrating the resilience of neuropsychological traits and associated brain systems in the early stages of AN.Citation
Leslie, M., Halls, D., Leppanen, J., Sedgewick, F., Lang, K., Fonville, L., ... Tchanturia, K. (2021). The neural correlates of a central coherence task in young women with anorexia nervosa. European Eating Disorders Review, 29(5), 744-755. https://doi.org/10.1002/erv.2852Publisher
WileyJournal
European Eating Disorders ReviewDOI
10.1002/erv.2852Additional Links
https://onlinelibrary.wiley.com/doi/full/10.1002/erv.2852Type
ArticleDescription
This is the peer reviewed version of the following article: Leslie, M., Halls, D., Leppanen, J., Sedgewick, F., Lang, K., Fonville, L., ... Tchanturia, K. (2021). The neural correlates of a central coherence task in young women with anorexia nervosa. European Eating Disorders Review, 29(5), 744-755, https://doi.org/10.1002/erv.2852, which has been published in final form at https://doi.org/10.1002/erv.2852. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-ArchivingISSN
1072-4133EISSN
1099-0968ae974a485f413a2113503eed53cd6c53
10.1002/erv.2852
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