Opinion of the Scientific Committee on Consumer safety (SCCS) – Final Opinion on propylparaben (CAS No 94-13-3, EC No 202-307-7)
dc.contributor.author | Bodin, Laurent | |
dc.contributor.author | Rogiers, Vera | |
dc.contributor.author | Bernauer, Ulrike | |
dc.contributor.author | Chaudhry, Qasim | |
dc.contributor.author | Coenraads, Pieter J. | |
dc.contributor.author | Dusinska, Maria | |
dc.contributor.author | Ezendam, Janine | |
dc.contributor.author | Gaffet, Eric | |
dc.contributor.author | Galli, Corrado Ludovico | |
dc.contributor.author | Granum, Berit | |
dc.contributor.author | Panteri, Eirini | |
dc.contributor.author | Rousselle, Christophe | |
dc.contributor.author | Stepnik, Maciej | |
dc.contributor.author | Vanhaecke, Tamara | |
dc.contributor.author | Wijnhoven, Susan | |
dc.contributor.author | Koutsodimou, Aglaia | |
dc.contributor.author | Uter, Wolfgang | |
dc.contributor.author | von Goetz, Natalie | |
dc.date.accessioned | 2021-07-20T13:49:54Z | |
dc.date.available | 2021-07-20T13:49:54Z | |
dc.identifier | doi: 10.1016/j.yrtph.2021.105005 | |
dc.identifier.citation | Bodin, L., Rogiers, V., Bernauer, U., Chaudhry, Q., Coenraads, P. J., Dusinska, M., Ezendam, J., Gaffet, E., Galli, C. L., Granum, B., Panteri, E., Rousselle, C., Stepnik, M., Vanhaecke, T., Wijnhoven, S., Koutsodimou, A., Uter, W., & von Goetz, N. (2021). Opinion of the Scientific Committee on Consumer safety (SCCS) – Final Opinion on propylparaben (CAS No 94-13-3, EC No 202-307-7). Regulatory Toxicology and Pharmacology, 125, 105005. https://doi.org/10.1016/j.yrtph.2021.105005 | |
dc.identifier.issn | 0273-2300 | |
dc.identifier.doi | 10.1016/j.yrtph.2021.105005 | |
dc.identifier.uri | http://hdl.handle.net/10034/625313 | |
dc.description | This article is not available on ChesterRep | |
dc.description.abstract | In cosmetic products, the ingredient propylparaben (CAS No 94-13-3, EC No 202-307-7) with the chemical names Propyl 4-hydroxybenzoate and 4-Hydroxybenzoic acid propyl ester is currently regulated as a preservative in a concentration up to 0.14 % (as acid) (Annex V/12a). In addition, a safe concentration was established for mixtures of parabens, where the sum of the individual concentrations should not exceed 0.8 % (as acid). However, in such mixtures the sum of the individual concentrations of butyl- and propylparaben and their salts should not exceed 0.14 %. Propylparaben was subject to different safety evaluations in 2005 (SCCP/0874/05), 2006 (SCCP/1017/06), 2008 (SCCP/1183/08), 2010 (SCCS/1348/10), 2011 (SCCS/1446/11), 2013 (SCCS/1514/13). On the basis of the safety assessment of propylparaben, and considering the concerns related to potential endocrine disrupting properties, the SCCS has concluded that propylparaben is safe when used as a preservative in cosmetic products up to a maximum concentration of 0.14 %. The available data on propylparaben provide some indications for potential endocrine effects. However, the current level of evidence is not sufficient to regard it as an endocrine disrupting substance, or to derive a toxicological point of departure based on endocrine disrupting properties for use in human health risk assessment. The SCCS mandates do not address environmental aspects. Therefore, this assessment did not cover the safety of propylparaben for the environment. | |
dc.publisher | Elsevier | |
dc.relation.url | https://www.sciencedirect.com/science/article/abs/pii/S027323002100146X?via%3Dihub | |
dc.rights | Licence for AM version of this article: This article is under embargo with an end date yet to be finalised. | |
dc.rights | Embargo: ends 9999-12-31 | |
dc.source | issn: 02732300 | |
dc.title | Opinion of the Scientific Committee on Consumer safety (SCCS) – Final Opinion on propylparaben (CAS No 94-13-3, EC No 202-307-7) | |
dc.type | Article | |
dc.contributor.department | Alternative Energies and Atomic Energy Commission, France; Vrije Universiteit; Federal Institute for Risk Assessment, Berlin; University of Chester; University Medical Center Groningen; Norwegian Institute for Air Research; National Institute for Public Health and the Environment, The Netherlands; Université de Lorraine; University of Milan; Norwegian Institute of Public Health; National and Kapodistrian University of Athens; French Agency for Food; Qsar Lab Ltd, Poland; Centre for Safety of Substances and Products, The Netherlands; Centre for Substances and Integrated Risk Assessment, The Netherlands; General Chemical State Laboratory, Greece; University of Erlangen/Nurnberg; Federal Office of Public Health, Switzerland | |
dc.identifier.journal | Regulatory Toxicology and Pharmacology | |
dc.date.updated | 2021-07-20T13:49:54Z | |
dc.date.accepted | 2021-07-09 |