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dc.contributor.authorSpencer, Andrew R A
dc.contributor.authorKorde, Rishi
dc.contributor.authorFont, Marc
dc.contributor.authorLarrosa, Igor; orcid: 0000-0002-5391-7424
dc.date.accessioned2021-07-20T13:49:23Z
dc.date.available2021-07-20T13:49:23Z
dc.date.issued2020-03-31
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625285/article.pdf?sequence=2
dc.identifier.citationChemical science, volume 11, issue 16, page 4204-4208
dc.identifier.urihttp://hdl.handle.net/10034/625285
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: ppub 2020-03-01, epub 2020-03-31
dc.descriptionPublication status: Published
dc.descriptionFunder: Engineering and Physical Sciences Research Council; Grant(s): EP/L014017/2
dc.description.abstractOver the last few decades C-H olefination has received significant interest, due to the importance and usefulness of aryl olefins both as synthetic targets and intermediates. While a wide range of <i>ortho</i>-olefination protocols have been developed, only a small number of <i>meta</i>-olefinations are currently available. Importantly, the most common approach to <i>meta</i>-olefination, using a large <i>meta</i>-directing template, is not suitable for substrates such as fluorobenzenes, which cannot be derivatised. We report that the <i>meta</i>-selective olefination of fluoroarenes can be achieved <i>via</i> the use of CO<sub>2</sub> as a traceless directing group, which can be easily installed and removed in a one-pot process. Furthermore, this approach avoids the use of stoichiometric Ag(i)-salts, commonly used in C-H olefinations, and affords complete <i>meta</i>- over <i>ortho</i>/<i>para</i>-regioselectivity.
dc.languageeng
dc.rightsLicence for this article: cc by
dc.sourceissn: 2041-6520
dc.sourceessn: 2041-6539
dc.sourcenlmid: 101545951
dc.title<i>meta</i>-Selective olefination of fluoroarenes with alkynes using CO<sub>2</sub> as a traceless directing group.
dc.typearticle
dc.date.updated2021-07-20T13:49:22Z


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