The Drosophila Larval Locomotor Circuit Provides a Model to Understand Neural Circuit Development and Function
AuthorsHunter, Iain; email: Iain.email@example.com
Zarin, Aref Arzan
Baines, Richard A.
MetadataShow full item record
AbstractIt is difficult to answer important questions in neuroscience, such as: “how do neural circuits generate behaviour?,” because research is limited by the complexity and inaccessibility of the mammalian nervous system. Invertebrate model organisms offer simpler networks that are easier to manipulate. As a result, much of what we know about the development of neural circuits is derived from work in crustaceans, nematode worms and arguably most of all, the fruit fly, Drosophila melanogaster. This review aims to demonstrate the utility of the Drosophila larval locomotor network as a model circuit, to those who do not usually use the fly in their work. This utility is explored first by discussion of the relatively complete connectome associated with one identified interneuron of the locomotor circuit, A27h, and relating it to similar circuits in mammals. Next, it is developed by examining its application to study two important areas of neuroscience research: critical periods of development and interindividual variability in neural circuits. In summary, this article highlights the potential to use the larval locomotor network as a “generic” model circuit, to provide insight into mammalian circuit development and function.
CitationFrontiers in Neural Circuits, volume 15, page 684969
PublisherFrontiers Media S.A.
DescriptionFrom Frontiers via Jisc Publications Router
History: collection 2021, received 2021-03-24, accepted 2021-06-09, epub 2021-07-01
Publication status: Published