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dc.contributor.authorVyas, Cian; orcid: 0000-0001-6030-1962; email: cian.vyas@manchester.ac.uk
dc.contributor.authorMishbak, Hussein
dc.contributor.authorCooper, Glen
dc.contributor.authorPeach, Chris
dc.contributor.authorPereira, Ruben F.
dc.contributor.authorBartolo, Paulo
dc.date.accessioned2021-07-09T15:41:02Z
dc.date.available2021-07-09T15:41:02Z
dc.date.issued2020-07-09
dc.date.submitted2019-09-26
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625205/40898_2020_Article_8.pdf?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625205/40898_2020_Article_8_nlm.xml?sequence=3
dc.identifier.citationBiomanufacturing Reviews, volume 5, issue 1, page 2
dc.identifier.urihttp://hdl.handle.net/10034/625205
dc.descriptionFrom Springer Nature via Jisc Publications Router
dc.descriptionHistory: received 2019-09-26, accepted 2020-06-29, registration 2020-06-29, pub-electronic 2020-07-09, online 2020-07-09, pub-print 2020-12
dc.descriptionPublication status: Published
dc.descriptionFunder: Engineering and Physical Sciences Research Council; doi: http://dx.doi.org/10.13039/501100000266; Grant(s): EP/L014904/1
dc.descriptionFunder: Fundação para a Ciência e a Tecnologia; doi: http://dx.doi.org/10.13039/501100001871; Grant(s): PTDC/MEC-GIN/29232/2017, 0245_IBEROS_1_E
dc.description.abstractAbstract: Articular cartilage and the underlying subchondral bone are crucial in human movement and when damaged through disease or trauma impacts severely on quality of life. Cartilage has a limited regenerative capacity due to its avascular composition and current therapeutic interventions have limited efficacy. With a rapidly ageing population globally, the numbers of patients requiring therapy for osteochondral disorders is rising, leading to increasing pressures on healthcare systems. Research into novel therapies using tissue engineering has become a priority. However, rational design of biomimetic and clinically effective tissue constructs requires basic understanding of osteochondral biological composition, structure, and mechanical properties. Furthermore, consideration of material design, scaffold architecture, and biofabrication strategies, is needed to assist in the development of tissue engineering therapies enabling successful translation into the clinical arena. This review provides a starting point for any researcher investigating tissue engineering for osteochondral applications. An overview of biological properties of osteochondral tissue, current clinical practices, the role of tissue engineering and biofabrication, and key challenges associated with new treatments is provided. Developing precisely engineered tissue constructs with mechanical and phenotypic stability is the goal. Future work should focus on multi-stimulatory environments, long-term studies to determine phenotypic alterations and tissue formation, and the development of novel bioreactor systems that can more accurately resemble the in vivo environment.
dc.languageen
dc.publisherSpringer International Publishing
dc.rightsLicence for this article: http://creativecommons.org/licenses/by/4.0/
dc.sourcepissn: 2363-507X
dc.sourceeissn: 2363-5088
dc.subjectOriginal Article
dc.subjectArticular cartilage
dc.subjectOsteochondral tissue
dc.subjectTissue engineering
dc.subjectBiofabrication
dc.subjectBioprinting
dc.subject3D printing
dc.subjectRegenerative medicine
dc.titleBiological perspectives and current biofabrication strategies in osteochondral tissue engineering
dc.typearticle
dc.date.updated2021-07-09T15:41:02Z
dc.date.accepted2020-06-29


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