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dc.contributor.authorRamsden, Jeremy I
dc.contributor.authorCosgrove, Sebastian C; orcid: 0000-0001-9541-7201; email: sebastian.cosgrove@manchester.ac.uk
dc.contributor.authorTurner, Nicholas J; orcid: 0000-0002-8708-0781
dc.date.accessioned2021-07-09T01:08:07Z
dc.date.available2021-07-09T01:08:07Z
dc.date.issued2020-10-07
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625197/article.pdf?sequence=2
dc.identifier.citationChemical science, volume 11, issue 41, page 11104-11112
dc.identifier.urihttp://hdl.handle.net/10034/625197
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: ppub 2020-10-01, epub 2020-10-07
dc.descriptionPublication status: Published
dc.descriptionFunder: European Research Council; Grant(s): 742987
dc.descriptionFunder: Engineering and Physical Sciences Research Council; Grant(s): EP/S01778X/1
dc.description.abstractThe use of biocatalysts for fragment-based drug discovery has yet to be fully investigated, despite the promise enzymes hold for the synthesis of poly-functional, non-protected small molecules. Here we analyze products of the biocatalysis literature to demonstrate the potential for not only fragment generation, but also the enzyme-mediated elaboration of these fragments. Our analysis demonstrates that biocatalytic products can readily populate 3D chemical space, offering diverse catalytic approaches to help generate new, bioactive molecules.
dc.languageeng
dc.rightsLicence for this article: cc by
dc.sourceissn: 2041-6520
dc.sourceessn: 2041-6539
dc.sourcenlmid: 101545951
dc.titleIs it time for biocatalysis in fragment-based drug discovery?
dc.typearticle
dc.date.updated2021-07-09T01:08:07Z


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