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dc.contributor.authorConstantin, Timothée; orcid: 0000-0001-5376-1557
dc.contributor.authorJuliá, Fabio; orcid: 0000-0001-8903-4482
dc.contributor.authorSheikh, Nadeem S; orcid: 0000-0002-0716-7562
dc.contributor.authorLeonori, Daniele; orcid: 0000-0002-7692-4504
dc.date.accessioned2021-07-09T01:08:02Z
dc.date.available2021-07-09T01:08:02Z
dc.date.issued2020-10-20
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625195/article.pdf?sequence=2
dc.identifier.citationChemical science, volume 11, issue 47, page 12822-12828
dc.identifier.urihttp://hdl.handle.net/10034/625195
dc.descriptionFrom Europe PMC via Jisc Publications Router
dc.descriptionHistory: ppub 2020-10-01, epub 2020-10-20
dc.descriptionPublication status: Published
dc.descriptionFunder: Engineering and Physical Sciences Research Council; Grant(s): EP/P004997/1
dc.descriptionFunder: European Research Council; Grant(s): 758427
dc.description.abstractThe generation of aryl radicals from the corresponding halides by redox chemistry is generally considered a difficult task due to their highly negative reduction potentials. Here we demonstrate that α-aminoalkyl radicals can be used as both initiators and chain-carriers for the radical coupling of aryl halides with pyrrole derivatives, a transformation often employed to evaluate new highly reducing photocatalysts. This mode of reactivity obviates for the use of strong reducing species and was also competent in the formation of sp<sup>2</sup> C-P bonds. Mechanistic studies have delineated some of the key features operating that trigger aryl radical generation and also propagate the chain process.
dc.languageeng
dc.rightsLicence for this article: cc by-nc
dc.sourceissn: 2041-6520
dc.sourceessn: 2041-6539
dc.sourcenlmid: 101545951
dc.titleA case of chain propagation: α-aminoalkyl radicals as initiators for aryl radical chemistry.
dc.typearticle
dc.date.updated2021-07-09T01:08:02Z


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