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dc.contributor.authorRomagnoli, Cecilia; orcid: 0000-0001-6615-5601; email: cecilia.romagnoli@unifi.it
dc.contributor.authorSharma, Preeti; email: preeti.sharma@unifi.it
dc.contributor.authorZonefrati, Roberto; email: roberto.zonefrati@unifi.it
dc.contributor.authorPalmini, Gaia; orcid: 0000-0002-8376-7404; email: gaia.palmini@unifi.it
dc.contributor.authorLucattelli, Elena; orcid: 0000-0002-1501-8022; email: elena.lucattelli@gmail.com
dc.contributor.authorWard, Donald T.; email: d.ward@manchester.ac.uk
dc.contributor.authorEllinger, Isabella; orcid: 0000-0001-6335-076X; email: isabella.ellinger@meduniwien.ac.at
dc.contributor.authorInnocenti, Marco; email: marco.innocenti@unifi.it
dc.contributor.authorBrandi, Maria Luisa; orcid: 0000-0002-8741-0592; email: marialuisa.brandi@unifi.it
dc.date.accessioned2021-07-08T01:29:37Z
dc.date.available2021-07-08T01:29:37Z
dc.date.issued2021-07-06
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625180/ijms-22-07282.xml?sequence=2
dc.identifierhttps://chesterrep.openrepository.com/bitstream/handle/10034/625180/ijms-22-07282.pdf?sequence=3
dc.identifier.citationInternational Journal of Molecular Sciences, volume 22, issue 14, page e7282
dc.identifier.urihttp://hdl.handle.net/10034/625180
dc.descriptionFrom MDPI via Jisc Publications Router
dc.descriptionHistory: accepted 2021-07-02, pub-electronic 2021-07-06
dc.descriptionPublication status: Published
dc.descriptionFunder: H2020 Marie Skłodowska-Curie Actions; Grant(s): 675228
dc.description.abstractSkeletal muscle has an outstanding capacity for regeneration in response to injuries, but there are disorders in which this process is seriously impaired, such as sarcopenia. Pharmacological treatments to restore muscle trophism are not available, therefore, the identification of suitable therapeutic targets that could be useful for the treatment of skeletal reduced myogenesis is highly desirable. In this in vitro study, we explored the expression and function of the calcium-sensing receptor (CaSR) in human skeletal muscle tissues and their derived satellite cells. The results obtained from analyses with various techniques of gene and protein CaSR expression and of its secondary messengers in response to calcium (Ca2+) and CaSR drugs have demonstrated that this receptor is not present in human skeletal muscle tissues, neither in the established satellite cells, nor during in vitro myogenic differentiation. Taken together, our data suggest that, although CaSR is a very important drug target in physiology and pathology, this receptor probably does not have any physiological role in skeletal muscle in normal conditions.
dc.languageen
dc.publisherMDPI
dc.rightsLicence for this article: https://creativecommons.org/licenses/by/4.0/
dc.sourceeissn: 1422-0067
dc.subjectskeletal muscle
dc.subjectsatellite cells
dc.subjectmyogenesis
dc.subjectcalcium-sensing receptor
dc.subjectG protein-coupled receptors
dc.titleStudy of the Expression and Function of Calcium-Sensing Receptor in Human Skeletal Muscle
dc.typearticle
dc.date.updated2021-07-08T01:29:37Z
dc.date.accepted2021-07-02


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